Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-B,HLA-C,HLA-E
  • Mouse genes H2-T3
  • Rat genes
  • Zfish genes mhc1zaa,mhc1zba,mhc1zca,mhc1zea,mhc1zfa,mhc1zja,mhc1zka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-T3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IMP		Human	PMID:12411439
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IDA		Human	PMID:16474394
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IDA		Human	PMID:18339401
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IDA		Human	PMID:18448674
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IDA		Human	PMID:25631937
Molecular Function	GO:0030881	beta-2-microglobulin binding	HLA-E	IDA		Human	PMID:30087334
Molecular Function	GO:0042288	MHC class I protein binding	HLA-E	IDA		Human	PMID:9754572
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	HLA-E	IPI	UniProtKB:Q13241	Human	PMID:25631937
Molecular Function	GO:0042605	peptide antigen binding	HLA-B	IDA		Human	PMID:22031944
Molecular Function	GO:0042605	peptide antigen binding	HLA-B	IDA		Human	PMID:23646949
Molecular Function	GO:0042605	peptide antigen binding	HLA-C	IDA		Human	PMID:22031944
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:10799855
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IMP		Human	PMID:12411439
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:16474394
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:18083576
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:18339401
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:18448674
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:23335510
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:25631937
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:30087334
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:9427624
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:9486650
Molecular Function	GO:0042605	peptide antigen binding	HLA-E	IDA		Human	PMID:9754572
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:P43628	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:P43632	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:Q9BX59	Human	PMID:26439010
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:Q14943	Human	PMID:27649529
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:Q8N423	Human	PMID:27649529
Molecular Function	GO:0005515	protein binding	HLA-B	IPI	UniProtKB:P43626	Human	PMID:28546555
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43627	Human	PMID:18322206
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43628	Human	PMID:18322206
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43626	Human	PMID:18624290
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:Q14954	Human	PMID:18624290
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:F2VZG2	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43626	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43628	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43632	Human	PMID:19858347
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:Q14943	Human	PMID:27649529
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:P43626	Human	PMID:28546555
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:Q14954	Human	PMID:28546555
Molecular Function	GO:0005515	protein binding	HLA-C	IPI	UniProtKB:Q14953	Human	PMID:28685972
Molecular Function	GO:0005515	protein binding	HLA-E	IPI	UniProtKB:Q13241	Human	PMID:18083576
Molecular Function	GO:0005515	protein binding	HLA-E	IPI	UniProtKB:P30511	Human	PMID:20483783
Molecular Function	GO:0005515	protein binding	HLA-E	IPI	UniProtKB:P61769	Human	PMID:9427624
Molecular Function	GO:0005515	protein binding	HLA-E	IPI	UniProtKB:Q03519	Human	PMID:9427624
Molecular Function	GO:0051087	protein-folding chaperone binding	HLA-B	IPI	UniProtKB:P27797	Human	PMID:15056662
Molecular Function	GO:0005102	signaling receptor binding	HLA-B	IPI	UniProtKB:Q8N423	Human	PMID:20008523
Molecular Function	GO:0005102	signaling receptor binding	HLA-B	IPI	UniProtKB:Q13241	Human	PMID:8046333
Molecular Function	GO:0005102	signaling receptor binding	HLA-E	IPI	UniProtKB:P26715	Human	PMID:18448674
Molecular Function	GO:0005102	signaling receptor binding	HLA-E	IPI	UniProtKB:P26717	Human	PMID:18448674
Molecular Function	GO:0005102	signaling receptor binding	HLA-E	IPI	UniProtKB:Q13241	Human	PMID:18448674
Molecular Function	GO:0042608	T cell receptor binding	HLA-E	IDA		Human	PMID:16474394
Molecular Function	GO:0046977	TAP binding	HLA-B	IDA		Human	PMID:8617941
Molecular Function	GO:0046977	TAP binding	HLA-C	IDA		Human	PMID:8617941
Molecular Function	GO:0046977	TAP binding	HLA-C	IDA		Human	PMID:8805302
Cellular Component	GO:0009986	cell surface	HLA-B	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	HLA-B	IDA		Human	PMID:22031944
Cellular Component	GO:0009986	cell surface	HLA-B	IDA		Human	PMID:9754572
Cellular Component	GO:0009986	cell surface	HLA-C	IDA		Human	PMID:22031944
Cellular Component	GO:0009986	cell surface	HLA-C	IDA		Human	PMID:9754572
Cellular Component	GO:0009986	cell surface	HLA-E	IDA		Human	PMID:12411439
Cellular Component	GO:0009986	cell surface	HLA-E	IDA		Human	PMID:25631937
Cellular Component	GO:0009986	cell surface	HLA-E	IDA		Human	PMID:9754572
Cellular Component	GO:0005783	endoplasmic reticulum	HLA-B	IDA		Human	PMID:20946353
Cellular Component	GO:0005783	endoplasmic reticulum	HLA-C	IDA		Human	PMID:20946353
Cellular Component	GO:0070062	extracellular exosome	HLA-B	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	HLA-B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HLA-B	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	HLA-B	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HLA-C	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HLA-E	HDA		Human	PMID:20458337
Cellular Component	GO:0005794	Golgi apparatus	HLA-B	IDA		Human	PMID:20946353
Cellular Component	GO:0005794	Golgi apparatus	HLA-C	IDA		Human	PMID:20946353
Cellular Component	GO:0016020	membrane	HLA-B	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	HLA-C	HDA		Human	PMID:19946888
Cellular Component	GO:0042612	MHC class I protein complex	HLA-B	IDA		Human	PMID:22031944
Cellular Component	GO:0042612	MHC class I protein complex	HLA-C	IDA		Human	PMID:22031944
Cellular Component	GO:0042612	MHC class I protein complex	HLA-E	IDA		Human	PMID:12411439
Cellular Component	GO:0042612	MHC class I protein complex	HLA-E	IDA		Human	PMID:16474394
Cellular Component	GO:0042612	MHC class I protein complex	HLA-E	IDA		Human	PMID:18448674
Cellular Component	GO:0032398	MHC class Ib protein complex	HLA-E	IDA		Human	PMID:23335510
Cellular Component	GO:0032398	MHC class Ib protein complex	HLA-E	IDA		Human	PMID:25631937
Cellular Component	GO:0032398	MHC class Ib protein complex	HLA-E	IDA		Human	PMID:30087334
Cellular Component	GO:0032398	MHC class Ib protein complex	HLA-E	IDA		Human	PMID:9427624
Cellular Component	GO:0005886	plasma membrane	HLA-E	IDA		Human	PMID:17179229
Cellular Component	GO:0005886	plasma membrane	HLA-E	IDA		Human	PMID:9427624
Biological Process	GO:0002250	adaptive immune response	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0019731	antibacterial humoral response	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0002486	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA-B	IDA		Human	PMID:22031944
Biological Process	GO:0002486	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA-C	IDA		Human	PMID:22031944
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA-E	IDA		Human	PMID:9754572
Biological Process	GO:0002477	antigen processing and presentation of exogenous peptide antigen via MHC class Ib	HLA-E	IDA		Human	PMID:30087334
Biological Process	GO:0036037	CD8-positive, alpha-beta T cell activation	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0050830	defense response to Gram-positive bacterium	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0016045	detection of bacterium	HLA-B	IMP		Human	PMID:22321387
Biological Process	GO:0006955	immune response	HLA-B	IMP		Human	PMID:22321387
Biological Process	GO:0002519	natural killer cell tolerance induction	HLA-E	IDA		Human	PMID:9486650
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:10799855
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:17179229
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:23335510
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:9486650
Biological Process	GO:0001815	positive regulation of antibody-dependent cellular cytotoxicity	HLA-E	IDA		Human	PMID:30134159
Biological Process	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	HLA-E	IDA		Human	PMID:28676677
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0002639	positive regulation of immunoglobulin production	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0032736	positive regulation of interleukin-13 production	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0032753	positive regulation of interleukin-4 production	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	HLA-E	IDA		Human	PMID:30134159
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:23335510
Biological Process	GO:0002717	positive regulation of natural killer cell mediated immunity	HLA-E	IDA		Human	PMID:9754572
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	HLA-E	IDA		Human	PMID:30134159
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	HLA-B	IDA		Human	PMID:2420472
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0032759	positive regulation of TRAIL production	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-B	IDA		Human	PMID:18502829
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-B	IDA		Human	PMID:2784569
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-B	IDA		Human	PMID:8046333
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:25631937
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-E	IDA		Human	PMID:9754572
Biological Process	GO:2001198	regulation of dendritic cell differentiation	HLA-B	IMP		Human	PMID:20008523
Biological Process	GO:0032655	regulation of interleukin-12 production	HLA-B	IMP		Human	PMID:20008523
Biological Process	GO:0032675	regulation of interleukin-6 production	HLA-B	IMP		Human	PMID:20008523
Biological Process	GO:0002715	regulation of natural killer cell mediated immunity	HLA-E	IDA		Human	PMID:18448674
Biological Process	GO:0002667	regulation of T cell anergy	HLA-B	IMP		Human	PMID:20008523

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern