Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse H2ax

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes H2AX
- Mouse genes H2ax
- Rat genes H2ax
- Zfish genes h2ax
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2ax

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	H2ax	IDA		Mouse	PMID:11934988
Molecular Function	GO:0019899	enzyme binding	H2AX	IPI	UniProtKB:Q99504	Human	PMID:19234442
Molecular Function	GO:0042393	histone binding	H2AX	IPI	UniProtKB:O00213	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:12419185
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P38398	Human	PMID:12419185
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P49959	Human	PMID:12419185
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:12607005
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:12607005
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:16377563
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P49959	Human	PMID:16377563
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:16377563
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P32121	Human	PMID:16820410
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:17024177
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q08211	Human	PMID:17498979
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14191	Human	PMID:17498979
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P38398	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P38398	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:18583988
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P49959	Human	PMID:18583988
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:18583988
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P45983	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P46933-1	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P49959	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q6P4T3	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P02545	Human	PMID:20000738
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P62805	Human	PMID:20000738
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:20075863
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O15297	Human	PMID:20118229
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:20159462
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P51532	Human	PMID:20224553
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P62805	Human	PMID:20224553
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q16695	Human	PMID:20224553
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q9Z0X1:PRO_0000022031	Human	PMID:20360685
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q15554	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q14676	Human	PMID:21293379
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q12888	Human	PMID:21317870
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q15554	Human	PMID:21824286
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q6ZW49-1	Human	PMID:22064073
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:22157895
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P49959	Human	PMID:22157895
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q15554	Human	PMID:22157895
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P38398	Human	PMID:22193777
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:O60934	Human	PMID:22565321
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P02545	Human	PMID:23658700
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P62805	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q99986	Human	PMID:25923214
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q7Z4V5	Human	PMID:26721387
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q9BUR4	Human	PMID:26734725
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q9BUR4	Human	PMID:27715493
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P58876	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P62805	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P58876	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:P62805	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	H2AX	IPI	UniProtKB:Q16695	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	H2ax	IPI	UniProtKB:Q9Z277	Mouse	MGI:MGI:3829305\|PMID:19092802
Molecular Function	GO:0005515	protein binding	H2ax	IPI	UniProtKB:Q80V62	Mouse	MGI:MGI:5508607\|PMID:17304220
Molecular Function	GO:0005515	protein binding	H2ax	IPI	UniProtKB:Q9Z0X1	Mouse	MGI:MGI:4442265\|PMID:20360685
Molecular Function	GO:0005515	protein binding	H2ax	IPI	MGI:MGI:1340042	Mouse	PMID:25634095
Cellular Component	GO:0005813	centrosome	H2AX	IDA		Human	PMID:17498979
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:18283110
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:15657431
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:27760146
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:18694567
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:17696610
Cellular Component	GO:0000785	chromatin	H2ax	IDA		Mouse	PMID:11934988
Cellular Component	GO:0005694	chromosome	H2ax	IDA		Mouse	MGI:MGI:6272683\|PMID:30272023
Cellular Component	GO:0005694	chromosome	H2ax	IDA		Mouse	MGI:MGI:6478065\|PMID:30746471
Cellular Component	GO:0005694	chromosome	H2ax	IDA		Mouse	MGI:MGI:6400008\|PMID:30949703
Cellular Component	GO:0005694	chromosome	H2ax	IDA		Mouse	MGI:MGI:5465514\|PMID:23039116
Cellular Component	GO:0000781	chromosome, telomeric region	H2AX	IDA		Human	PMID:15149599
Cellular Component	GO:0000794	condensed nuclear chromosome	H2ax	IDA		Mouse	PMID:22711701
Cellular Component	GO:0000794	condensed nuclear chromosome	H2ax	IDA		Mouse	PMID:20551173
Cellular Component	GO:0000794	condensed nuclear chromosome	H2ax	IDA		Mouse	PMID:26490168
Cellular Component	GO:0000794	condensed nuclear chromosome	H2ax	IDA		Mouse	PMID:23555294
Cellular Component	GO:0000794	condensed nuclear chromosome	H2ax	IDA		Mouse	PMID:22164254
Cellular Component	GO:0070062	extracellular exosome	H2AX	HDA		Human	PMID:23533145
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:17475928
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:31839538
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:19176879
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:17696610
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:14611631
Cellular Component	GO:0001673	male germ cell nucleus	H2ax	IDA		Mouse	PMID:17912366
Cellular Component	GO:0016607	nuclear speck	H2AX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	H2AX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:11331621
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:15604234
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:16319397
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:17974976
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:19734146
Cellular Component	GO:0005634	nucleus	H2AX	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	H2AX	IDA		Human	PMID:23235539
Cellular Component	GO:0005634	nucleus	H2AX	IMP		Human	PMID:24507776
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Mouse	MGI:MGI:4442265\|PMID:20360685
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Mouse	PMID:22297488
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Mouse	PMID:20516196
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Mouse	PMID:21991325
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Mouse	PMID:21911473
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Rat	PMID:16706843\|RGD:2317719
Cellular Component	GO:0005634	nucleus	H2ax	IDA		Rat	PMID:28904242\|RGD:127284557
Cellular Component	GO:0005657	replication fork	H2ax	IDA		Mouse	PMID:15364958
Cellular Component	GO:0090734	site of DNA damage	H2AX	IMP		Human	PMID:27248496
Cellular Component	GO:0035861	site of double-strand break	H2AX	IDA		Human	PMID:21270334
Cellular Component	GO:0035861	site of double-strand break	H2ax	IDA		Mouse	PMID:22699483
Cellular Component	GO:0035861	site of double-strand break	H2ax	IDA		Mouse	PMID:23133398
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:25675407
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:18070917
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:25634095
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:28031483
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:22854038
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:20577743
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:31839538
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:19074312
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:21539824
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:23133398
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:18316482
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:26358182
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:22699483
Cellular Component	GO:0001741	XY body	H2ax	IDA		Mouse	PMID:23810942
Biological Process	GO:0071480	cellular response to gamma radiation	H2ax	IDA		Rat	PMID:17552875\|RGD:8693710
Biological Process	GO:0090398	cellular senescence	H2ax	IEP		Rat	PMID:19946210\|RGD:8693719
Biological Process	GO:0021987	cerebral cortex development	H2ax	IEP		Rat	PMID:3622934\|RGD:8693731
Biological Process	GO:0000077	DNA damage checkpoint signaling	H2AX	IDA		Human	PMID:17974976
Biological Process	GO:0006974	DNA damage response	H2AX	IDA		Human	PMID:15149599
Biological Process	GO:0006974	DNA damage response	H2AX	IMP		Human	PMID:27248496
Biological Process	GO:0006974	DNA damage response	h2ax	IDA		Zfish	PMID:18974873
Biological Process	GO:0006281	DNA repair	H2ax	IDA		Mouse	PMID:15364958
Biological Process	GO:0006281	DNA repair	H2ax	IMP	MGI:MGI:2156048	Mouse	PMID:11934988
Biological Process	GO:0000724	double-strand break repair via homologous recombination	H2ax	IMP	MGI:MGI:2156048	Mouse	PMID:11934988
Biological Process	GO:0007283	spermatogenesis	H2ax	IMP	MGI:MGI:2156048	Mouse	PMID:11934988
Biological Process	GO:0007283	spermatogenesis	H2ax	IEP		Rat	PMID:3932111\|RGD:8693729

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/24/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.