Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HAND1
  • Mouse genes Hand1
  • Rat genes Hand1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hand1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	HAND1	IPI	UniProtKB:P15923-1	Human	PMID:11802795
Molecular Function	GO:0043425	bHLH transcription factor binding	HAND1	IPI	UniProtKB:P15923-2	Human	PMID:11802795
Molecular Function	GO:0043425	bHLH transcription factor binding	HAND1	IPI	UniProtKB:Q99081	Human	PMID:11802795
Molecular Function	GO:0003677	DNA binding	Hand1	IDA		Mouse	PMID:15509787
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hand1	IDA		Mouse	MGI:MGI:3511603|PMID:15509787
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HAND1	IDA		Human	PMID:16043483
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	HAND1	IDA		Human	PMID:11802795
Molecular Function	GO:0019899	enzyme binding	Hand1	IPI	UniProtKB:Q64702	Mouse	MGI:MGI:4359361|PMID:17891141
Molecular Function	GO:0042802	identical protein binding	Hand1	IPI	UniProtKB:Q64279	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0042802	identical protein binding	Hand1	IDA		Mouse	PMID:23911935
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:Q92793	Human	PMID:16043483
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:P15923-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:P60371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HAND1	IPI	UniProtKB:Q86WV8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hand1	IPI	UniProtKB:P15806|UniProtKB:Q61039	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0005515	protein binding	Hand1	IPI	UniProtKB:Q61039	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0005515	protein binding	Hand1	IPI	UniProtKB:Q8BX65	Mouse	MGI:MGI:4359361|PMID:17891141
Molecular Function	GO:0005515	protein binding	Hand1	IPI	PR:P43267	Mouse	PMID:16759287
Molecular Function	GO:0005515	protein binding	Hand1	IPI	PR:P15806	Mouse	PMID:12070084
Molecular Function	GO:0005515	protein binding	Hand1	IPI	PR:Q64279	Mouse	PMID:15509787
Molecular Function	GO:0005515	protein binding	Hand1	IPI	PR:O70433	Mouse	PMID:15509787
Molecular Function	GO:0042803	protein homodimerization activity	Hand1	IPI	UniProtKB:Q64279	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HAND1	IDA		Human	PMID:11802795
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HAND1	IPI	UniProtKB:Q02078	Human	PMID:16043483
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HAND1	IPI	UniProtKB:Q06413	Human	PMID:16043483
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HAND1	IPI	UniProtKB:Q14814	Human	PMID:16043483
Molecular Function	GO:0043565	sequence-specific DNA binding	Hand1	IGI	MGI:MGI:98510	Mouse	PMID:12070084
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HAND1	IDA		Human	PMID:11802795
Molecular Function	GO:0001221	transcription coregulator binding	Hand1	IPI	UniProtKB:O70433	Mouse	MGI:MGI:3511603|PMID:15509787
Molecular Function	GO:0008134	transcription factor binding	Hand1	IPI	PR:Q08775	Mouse	PMID:19144722
Molecular Function	GO:0008134	transcription factor binding	Hand1	IPI	UniProtKB:P15923	Mouse	PMID:7814632
Cellular Component	GO:0005737	cytoplasm	HAND1	IDA		Human	PMID:11802795
Cellular Component	GO:0005730	nucleolus	Hand1	IDA		Mouse	MGI:MGI:4359361|PMID:17891141
Cellular Component	GO:0005654	nucleoplasm	Hand1	IDA		Mouse	MGI:MGI:4359361|PMID:17891141
Cellular Component	GO:0005634	nucleus	HAND1	IDA		Human	PMID:11802795
Cellular Component	GO:0005634	nucleus	Hand1	IDA		Mouse	PMID:15509787
Cellular Component	GO:0005634	nucleus	Hand1	IDA		Mouse	PMID:19144722
Cellular Component	GO:0005634	nucleus	Hand1	IDA		Rat	PMID:23911935|RGD:8655524
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:0001525	angiogenesis	Hand1	IMP	MGI:MGI:3042297	Mouse	PMID:15073150
Biological Process	GO:0001824	blastocyst development	HAND1	IEP		Human	PMID:11802795
Biological Process	GO:0003218	cardiac left ventricle formation	HAND1	IMP		Human	PMID:18276607
Biological Process	GO:0003219	cardiac right ventricle formation	HAND1	IMP		Human	PMID:18276607
Biological Process	GO:0060411	cardiac septum morphogenesis	HAND1	IMP		Human	PMID:19586923
Biological Process	GO:0060536	cartilage morphogenesis	Hand1	IGI	MGI:MGI:103580	Mouse	PMID:17764670
Biological Process	GO:0030154	cell differentiation	Hand1	IGI	MGI:MGI:98363	Mouse	PMID:16759287
Biological Process	GO:0061371	determination of heart left/right asymmetry	Hand1	IMP		Mouse	PMID:11076684
Biological Process	GO:0035050	embryonic heart tube development	Hand1	IMP	MGI:MGI:2153823	Mouse	PMID:9500551
Biological Process	GO:0003144	embryonic heart tube formation	Hand1	IMP		Mouse	PMID:11076684
Biological Process	GO:0007507	heart development	Hand1	IMP	MGI:MGI:2153824	Mouse	PMID:9500550
Biological Process	GO:0007507	heart development	Hand1	IMP	MGI:MGI:2386742,MGI:MGI:3514024,MGI:MGI:3514028	Mouse	PMID:15576406
Biological Process	GO:0007507	heart development	Hand1	IGI	MGI:MGI:103580	Mouse	PMID:15576406
Biological Process	GO:0001947	heart looping	Hand1	IMP	MGI:MGI:2153823	Mouse	PMID:9500551
Biological Process	GO:0001701	in utero embryonic development	Hand1	IMP	MGI:MGI:2153823	Mouse	PMID:9500551
Biological Process	GO:0060485	mesenchyme development	Hand1	IGI	MGI:MGI:103580	Mouse	PMID:17764670
Biological Process	GO:0001707	mesoderm formation	Hand1	IMP	MGI:MGI:2153824	Mouse	PMID:9500550
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Hand1	IDA		Mouse	PMID:19144722
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hand1	IGI	MGI:MGI:98363	Mouse	PMID:16759287
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Hand1	IGI	MGI:MGI:103580	Mouse	PMID:17764670
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAND1	IDA		Human	PMID:11802795
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAND1	IDA		Human	PMID:16043483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hand1	IDA		Mouse	PMID:16759287
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hand1	IDA		Mouse	PMID:15509787
Biological Process	GO:0001829	trophectodermal cell differentiation	HAND1	IEP		Human	PMID:11802795
Biological Process	GO:0060707	trophoblast giant cell differentiation	Hand1	IMP		Mouse	MGI:MGI:4359361|PMID:17891141
Biological Process	GO:0060707	trophoblast giant cell differentiation	Hand1	IMP		Mouse	MGI:MGI:3625684|PMID:16759287
Biological Process	GO:0060707	trophoblast giant cell differentiation	Hand1	IDA		Mouse	PMID:23911935
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	HAND1	IMP		Human	PMID:18276607
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Hand1	IMP	MGI:MGI:2153823	Mouse	PMID:9500551

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern