Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HAND2
  • Mouse genes Hand2
  • Rat genes Hand2
  • Zfish genes hand2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hand2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HAND2	IDA		Human	PMID:15486975
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hand2	IDA		Mouse	MGI:MGI:4362015|PMID:11812799
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Hand2	IMP		Rat	PMID:11994297|RGD:727369
Molecular Function	GO:0070888	E-box binding	HAND2	IDA		Human	PMID:15486975
Molecular Function	GO:0070888	E-box binding	Hand2	IDA		Mouse	MGI:MGI:4362015|PMID:11812799
Molecular Function	GO:0070888	E-box binding	Hand2	IDA		Mouse	PMID:20144608
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HAND2	IDA		Human	PMID:15486975
Molecular Function	GO:0005515	protein binding	HAND2	IPI	UniProtKB:Q06413	Human	PMID:15486975
Molecular Function	GO:0005515	protein binding	HAND2	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Hand2	IPI	UniProtKB:Q99N72	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Hand2	IPI	UniProtKB:Q64279	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0005515	protein binding	Hand2	IPI	UniProtKB:P15806|UniProtKB:Q64279	Mouse	MGI:MGI:3687816|PMID:10924525
Molecular Function	GO:0005515	protein binding	Hand2	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529|PMID:20599664
Molecular Function	GO:0005515	protein binding	Hand2	IPI	PR:Q60722	Mouse	PMID:15351717
Molecular Function	GO:0005515	protein binding	Hand2	IPI	PR:P42582	Mouse	PMID:12392994
Molecular Function	GO:0005515	protein binding	Hand2	IPI	PR:Q61286	Mouse	PMID:15351717
Molecular Function	GO:0005515	protein binding	Hand2	IPI	PR:P15806	Mouse	PMID:12070084
Molecular Function	GO:0005515	protein binding	Hand2	IPI	PR:P15806	Mouse	PMID:15351717
Molecular Function	GO:0005515	protein binding	Hand2	IPI	UniProtKB:A0A096MJY4	Rat	PMID:15486975|RGD:8554739
Molecular Function	GO:0042803	protein homodimerization activity	Hand2	IPI	UniProtKB:Q61039	Mouse	MGI:MGI:4362015|PMID:11812799
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HAND2	IDA		Human	PMID:16280598
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hand2	IPI	UniProtKB:P15806-1	Mouse	MGI:MGI:4362015|PMID:11812799
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hand2	IPI	UniProtKB:P46152	Rat	PMID:11994297|RGD:727369
Molecular Function	GO:0043565	sequence-specific DNA binding	Hand2	IGI	MGI:MGI:98510	Mouse	PMID:12070084
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HAND2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Hand2	IDA		Mouse	MGI:MGI:4362015|PMID:11812799
Molecular Function	GO:0001223	transcription coactivator binding	Hand2	IPI	UniProtKB:Q8BJ14	Rat	PMID:11994297|RGD:727369
Molecular Function	GO:0008134	transcription factor binding	Hand2	IPI	PR:Q08775	Mouse	PMID:19144722
Cellular Component	GO:0000785	chromatin	HAND2	IDA		Human	PMID:16280598
Cellular Component	GO:0000785	chromatin	HAND2	IDA		Human	PMID:24161931
Cellular Component	GO:0005634	nucleus	Hand2	IDA		Mouse	PMID:19144722
Cellular Component	GO:0005634	nucleus	Hand2	IDA		Rat	PMID:15485823|RGD:5132893
Cellular Component	GO:0032991	protein-containing complex	HAND2	IDA		Human	PMID:15486975
Cellular Component	GO:0005667	transcription regulator complex	Hand2	IDA		Mouse	MGI:MGI:4362015|PMID:11812799
Biological Process	GO:0007512	adult heart development	HAND2	IEP		Human	PMID:9878849
Biological Process	GO:0007512	adult heart development	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:9171826
Biological Process	GO:0006915	apoptotic process	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:19341725
Biological Process	GO:0003278	apoptotic process involved in heart morphogenesis	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:11784028
Biological Process	GO:0055007	cardiac muscle cell differentiation	hand2	IMP	ZFIN:ZDB-MRPHLNO-080930-4	Zfish	PMID:19607825
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	Hand2	IMP	MGI:MGI:2386570,MGI:MGI:3803647	Mouse	PMID:20144608
Biological Process	GO:0003219	cardiac right ventricle formation	Hand2	IMP		Mouse	MGI:MGI:1926848|PMID:11076755
Biological Process	GO:0010002	cardioblast differentiation	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:17681136
Biological Process	GO:0035051	cardiocyte differentiation	hand2	IMP	ZFIN:ZDB-GENO-990423-8	Zfish	PMID:15786591
Biological Process	GO:0003142	cardiogenic plate morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-110502-2	Zfish	PMID:10821756
Biological Process	GO:0003142	cardiogenic plate morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:10821756
Biological Process	GO:0003142	cardiogenic plate morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:10821756
Biological Process	GO:0060536	cartilage morphogenesis	Hand2	IGI	MGI:MGI:103577	Mouse	PMID:17764670
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	Hand2	IMP	MGI:MGI:2386570,MGI:MGI:3803647	Mouse	PMID:20144608
Biological Process	GO:0071407	cellular response to organic cyclic compound	Hand2	IEP		Rat	PMID:11073966|RGD:5132895
Biological Process	GO:0071300	cellular response to retinoic acid	Hand2	IEP		Rat	PMID:16619265|RGD:5131544
Biological Process	GO:0060982	coronary artery morphogenesis	Hand2	IMP	MGI:MGI:3715149,MGI:MGI:4838016	Mouse	PMID:21350214
Biological Process	GO:0061371	determination of heart left/right asymmetry	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:9576835
Biological Process	GO:0071908	determination of intestine left/right asymmetry	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:20627079
Biological Process	GO:0042733	embryonic digit morphogenesis	Hand2	IDA		Mouse	PMID:12070084
Biological Process	GO:0003144	embryonic heart tube formation	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:10821756
Biological Process	GO:0003144	embryonic heart tube formation	hand2	IMP	ZFIN:ZDB-GENO-110502-2	Zfish	PMID:10821756
Biological Process	GO:0003144	embryonic heart tube formation	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:10821756
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:10821756
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:10821756
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-110502-2	Zfish	PMID:10821756
Biological Process	GO:0048706	embryonic skeletal system development	Hand2	IGI	MGI:MGI:105923	Mouse	PMID:19017795
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:12588851
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-100809-8	Zfish	PMID:20573696
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hand2	IGI	ZFIN:ZDB-GENO-100809-9,ZFIN:ZDB-MRPHLNO-041109-1,ZFIN:ZDB-MRPHLNO-050209-12,ZFIN:ZDB-MRPHLNO-060822-7	Zfish	PMID:20573696
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hand2	IMP	ZFIN:ZDB-GENO-120523-18	Zfish	PMID:20573696
Biological Process	GO:1904019	epithelial cell apoptotic process	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:19341725
Biological Process	GO:0060047	heart contraction	hand2	IMP	ZFIN:ZDB-MRPHLNO-070920-4	Zfish	PMID:17637246
Biological Process	GO:0007507	heart development	Hand2	IGI	MGI:MGI:103577	Mouse	PMID:15576406
Biological Process	GO:0007507	heart development	Hand2	IEP		Rat	PMID:15486975|RGD:8554739
Biological Process	GO:0001947	heart looping	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:9171826
Biological Process	GO:0001947	heart looping	hand2	IGI	ZFIN:ZDB-MRPHLNO-130729-9	Zfish	PMID:27077543
Biological Process	GO:0003007	heart morphogenesis	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:11784028
Biological Process	GO:0003007	heart morphogenesis	hand2	IGI	ZFIN:ZDB-MRPHLNO-070529-1,ZFIN:ZDB-MRPHLNO-070529-2,ZFIN:ZDB-MRPHLNO-070529-3,ZFIN:ZDB-MRPHLNO-070529-4,ZFIN:ZDB-MRPHLNO-080930-4	Zfish	PMID:19607825
Biological Process	GO:0003007	heart morphogenesis	hand2	IMP	ZFIN:ZDB-MRPHLNO-070920-4	Zfish	PMID:17637246
Biological Process	GO:0003007	heart morphogenesis	hand2	IMP	ZFIN:ZDB-MRPHLNO-080930-4	Zfish	PMID:19607825
Biological Process	GO:0003007	heart morphogenesis	hand2	IGI	ZFIN:ZDB-GENO-190422-5	Zfish	PMID:30355621
Biological Process	GO:0003007	heart morphogenesis	hand2	IGI	ZFIN:ZDB-GENO-190422-4	Zfish	PMID:30355621
Biological Process	GO:0001701	in utero embryonic development	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:9171826
Biological Process	GO:0010463	mesenchymal cell proliferation	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:19341725
Biological Process	GO:0060485	mesenchyme development	Hand2	IGI	MGI:MGI:103577	Mouse	PMID:17764670
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:0043392	negative regulation of DNA binding	Hand2	IDA		Mouse	PMID:19144722
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Hand2	IDA		Mouse	PMID:19144722
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:19341725
Biological Process	GO:0010629	negative regulation of gene expression	HAND2	IMP		Human	PMID:24161931
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Hand2	IDA		Mouse	PMID:19144722
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Hand2	IMP	MGI:MGI:2653307	Mouse	PMID:19144722
Biological Process	GO:0014032	neural crest cell development	Hand2	IMP	MGI:MGI:1857639	Mouse	PMID:9671575
Biological Process	GO:0003357	noradrenergic neuron differentiation	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:17008447
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Hand2	IGI	MGI:MGI:103577	Mouse	PMID:17764670
Biological Process	GO:0001649	osteoblast differentiation	Hand2	IMP	MGI:MGI:2653307	Mouse	PMID:19144722
Biological Process	GO:0048935	peripheral nervous system neuron development	Hand2	IDA		Mouse	PMID:16145670
Biological Process	GO:0030859	polarized epithelial cell differentiation	hand2	IMP	ZFIN:ZDB-GENO-990423-8	Zfish	PMID:15786591
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	HAND2	IDA		Human	PMID:24161931
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	HAND2	IGI	UniProtKB:P63328	Human	PMID:24161931
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	HAND2	IGI	UniProtKB:Q02078	Human	PMID:24161931
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hand2	IGI	MGI:MGI:98510	Mouse	PMID:12070084
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hand2	IDA		Mouse	PMID:16145670
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HAND2	IMP		Human	PMID:24161931
Biological Process	GO:0010628	positive regulation of gene expression	HAND2	IMP		Human	PMID:24161931
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	HAND2	IMP		Human	PMID:24161931
Biological Process	GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAND2	IDA		Human	PMID:15486975
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAND2	IDA		Human	PMID:16280598
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HAND2	IDA		Human	PMID:24161931
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hand2	IDA		Mouse	MGI:MGI:4362015|PMID:11812799
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hand2	IGI	MGI:MGI:98510	Mouse	PMID:20144608
Biological Process	GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	HAND2	IDA		Human	PMID:16280598
Biological Process	GO:1903929	primary palate development	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:17531968
Biological Process	GO:0003342	proepicardium development	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:20413782
Biological Process	GO:0006355	regulation of DNA-templated transcription	Hand2	IDA		Mouse	PMID:15351717
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:0034103	regulation of tissue remodeling	HAND2	IDA		Human	PMID:24161931
Biological Process	GO:0060021	roof of mouth development	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:17531968
Biological Process	GO:0060021	roof of mouth development	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:19341725
Biological Process	GO:0001967	suckling behavior	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:17531968
Biological Process	GO:0048485	sympathetic nervous system development	Hand2	IDA		Mouse	PMID:16145670
Biological Process	GO:0048485	sympathetic nervous system development	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:17008447
Biological Process	GO:0048538	thymus development	Hand2	IMP		Mouse	MGI:MGI:4413411|PMID:19008477
Biological Process	GO:0030878	thyroid gland development	hand2	IMP	ZFIN:ZDB-GENO-071003-2	Zfish	PMID:17611226
Biological Process	GO:0030878	thyroid gland development	hand2	IMP	ZFIN:ZDB-GENO-071003-1	Zfish	PMID:17611226
Biological Process	GO:0043586	tongue development	Hand2	IMP	MGI:MGI:3715149	Mouse	PMID:17531968
Biological Process	GO:0061032	visceral serous pericardium development	Hand2	IMP	MGI:MGI:3715149,MGI:MGI:3801682	Mouse	PMID:21350214

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern