Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Has2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HAS2
- Mouse genes Has2
- Rat genes Has2
- Zfish genes has2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Has2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050501	hyaluronan synthase activity	HAS2	IMP		Human	PMID:22016393
Molecular Function	GO:0050501	hyaluronan synthase activity	HAS2	IDA		Human	PMID:30394292
Molecular Function	GO:0050501	hyaluronan synthase activity	Has2	IDA		Mouse	PMID:10455188
Molecular Function	GO:0050501	hyaluronan synthase activity	Has2	IDA		Rat	PMID:19635555\|RGD:8553259
Molecular Function	GO:0042802	identical protein binding	HAS2	IDA		Human	PMID:20507985
Molecular Function	GO:0005515	protein binding	HAS2	IPI	UniProtKB:O00219	Human	PMID:20507985
Molecular Function	GO:0005515	protein binding	HAS2	IPI	UniProtKB:O00219	Human	PMID:25795779
Molecular Function	GO:0005515	protein binding	HAS2	IPI	UniProtKB:Q92839	Human	PMID:25795779
Molecular Function	GO:0005515	protein binding	HAS2	IPI	UniProtKB:Q13107	Human	PMID:28604766
Cellular Component	GO:0005737	cytoplasm	Has2	IDA		Mouse	MGI:MGI:5619725\|PMID:24057227
Cellular Component	GO:0031410	cytoplasmic vesicle	Has2	IDA		Mouse	MGI:MGI:5619725\|PMID:24057227
Cellular Component	GO:0005789	endoplasmic reticulum membrane	HAS2	IDA		Human	PMID:30394292
Cellular Component	GO:1903561	extracellular vesicle	HAS2	IDA		Human	PMID:30394292
Cellular Component	GO:0005794	Golgi apparatus	HAS2	IDA		Human	PMID:25795779
Cellular Component	GO:0005794	Golgi apparatus	HAS2	IDA		Human	PMID:30394292
Cellular Component	GO:0005886	plasma membrane	HAS2	IDA		Human	PMID:20522558
Cellular Component	GO:0005886	plasma membrane	HAS2	IDA		Human	PMID:25795779
Cellular Component	GO:0005886	plasma membrane	HAS2	IDA		Human	PMID:30394292
Cellular Component	GO:0005886	plasma membrane	Has2	IDA		Mouse	PMID:10455188
Cellular Component	GO:0044853	plasma membrane raft	Has2	IDA		Mouse	PMID:22383528
Biological Process	GO:0036302	atrioventricular canal development	Has2	IMP		Mouse	MGI:MGI:1861536\|PMID:10930438
Biological Process	GO:0036302	atrioventricular canal development	has2	IGI	ZFIN:ZDB-GENE-040426-2843	Zfish	PMID:24430697
Biological Process	GO:0003171	atrioventricular valve development	has2	IGI	ZFIN:ZDB-MRPHLNO-060930-5,ZFIN:ZDB-MRPHLNO-111018-2	Zfish	PMID:21937601
Biological Process	GO:0003181	atrioventricular valve morphogenesis	has2	IMP	ZFIN:ZDB-MRPHLNO-060930-5	Zfish	PMID:21778427
Biological Process	GO:0001568	blood vessel development	has2	IGI	ZFIN:ZDB-MRPHLNO-130424-1,ZFIN:ZDB-MRPHLNO-140924-3,ZFIN:ZDB-MRPHLNO-140924-4	Zfish	PMID:24586357
Biological Process	GO:0060349	bone morphogenesis	Has2	IMP	MGI:MGI:2176070,MGI:MGI:4360705	Mouse	PMID:21246657
Biological Process	GO:0021535	cell migration in hindbrain	has2	IMP	ZFIN:ZDB-MRPHLNO-060930-5	Zfish	PMID:17392791
Biological Process	GO:0042074	cell migration involved in gastrulation	has2	IMP		Zfish	PMID:14729574
Biological Process	GO:0071498	cellular response to fluid shear stress	HAS2	IEP		Human	PMID:21551265
Biological Process	GO:0071347	cellular response to interleukin-1	HAS2	IEP		Human	PMID:20522558
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	HAS2	IDA		Human	PMID:17324121
Biological Process	GO:0071356	cellular response to tumor necrosis factor	HAS2	IEP		Human	PMID:20522558
Biological Process	GO:0060030	dorsal convergence	has2	IGI	ZFIN:ZDB-GENO-070516-4	Zfish	PMID:17331724
Biological Process	GO:0035050	embryonic heart tube development	has2	IMP	ZFIN:ZDB-MRPHLNO-060930-5,ZFIN:ZDB-MRPHLNO-060930-6	Zfish	PMID:18267096
Biological Process	GO:0090500	endocardial cushion to mesenchymal transition	Has2	IMP		Mouse	MGI:MGI:1861536\|PMID:10930438
Biological Process	GO:0044849	estrous cycle	Has2	IEP		Rat	PMID:24218629\|RGD:9588635
Biological Process	GO:0085029	extracellular matrix assembly	Has2	IDA		Mouse	MGI:MGI:5508296\|PMID:10455188
Biological Process	GO:0045226	extracellular polysaccharide biosynthetic process	Has2	IDA		Mouse	MGI:MGI:5508296\|PMID:10455188
Biological Process	GO:0031101	fin regeneration	has2	IMP	ZFIN:ZDB-MRPHLNO-160413-11	Zfish	PMID:26828861
Biological Process	GO:0031101	fin regeneration	has2	IMP	ZFIN:ZDB-MRPHLNO-160413-12	Zfish	PMID:26828861
Biological Process	GO:0003146	heart jogging	has2	IGI	ZFIN:ZDB-GENE-980528-2059	Zfish	PMID:18267096
Biological Process	GO:0001947	heart looping	has2	IGI	ZFIN:ZDB-GENE-040426-2843	Zfish	PMID:24430697
Biological Process	GO:0001947	heart looping	has2	IMP	ZFIN:ZDB-MRPHLNO-060930-5,ZFIN:ZDB-MRPHLNO-060930-6	Zfish	PMID:18267096
Biological Process	GO:0001947	heart looping	has2	IGI	ZFIN:ZDB-MRPHLNO-050228-1,ZFIN:ZDB-MRPHLNO-060930-5,ZFIN:ZDB-MRPHLNO-060930-6,ZFIN:ZDB-MRPHLNO-070710-1	Zfish	PMID:18267096
Biological Process	GO:0030213	hyaluronan biosynthetic process	HAS2	IDA		Human	PMID:17324121
Biological Process	GO:0030213	hyaluronan biosynthetic process	HAS2	IMP		Human	PMID:20507985
Biological Process	GO:0030213	hyaluronan biosynthetic process	HAS2	IMP		Human	PMID:22016393
Biological Process	GO:0030213	hyaluronan biosynthetic process	HAS2	IDA		Human	PMID:30394292
Biological Process	GO:0030213	hyaluronan biosynthetic process	Has2	IMP		Mouse	MGI:MGI:1861536\|PMID:10930438
Biological Process	GO:0030213	hyaluronan biosynthetic process	Has2	IDA		Mouse	PMID:10455188
Biological Process	GO:0030213	hyaluronan biosynthetic process	Has2	IDA		Mouse	PMID:8798545
Biological Process	GO:0030213	hyaluronan biosynthetic process	Has2	IEP		Rat	PMID:19635555\|RGD:8553259
Biological Process	GO:0030212	hyaluronan metabolic process	Has2	IMP	MGI:MGI:2176070,MGI:MGI:4360705	Mouse	PMID:21246657
Biological Process	GO:0001822	kidney development	Has2	IEP		Rat	PMID:17706761\|RGD:8553275
Biological Process	GO:0008078	mesodermal cell migration	has2	IMP		Zfish	PMID:14729574
Biological Process	GO:0030335	positive regulation of cell migration	HAS2	IMP		Human	PMID:22016393
Biological Process	GO:0008284	positive regulation of cell population proliferation	HAS2	IMP		Human	PMID:22016393
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	Has2	IDA		Rat	PMID:12186949\|RGD:9588629
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	Has2	IMP		Rat	PMID:17080198\|RGD:9588632
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Has2	IDA		Rat	PMID:12186949\|RGD:9588629
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	Has2	IMP		Rat	PMID:12186949\|RGD:9588629
Biological Process	GO:1900625	positive regulation of monocyte aggregation	HAS2	IMP		Human	PMID:20522558
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Has2	IMP		Rat	PMID:17080198\|RGD:9588632
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Has2	IMP		Rat	PMID:12186949\|RGD:9588629
Biological Process	GO:0035810	positive regulation of urine volume	Has2	IEP		Rat	PMID:19635555\|RGD:8553259
Biological Process	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	has2	IMP	ZFIN:ZDB-MRPHLNO-060930-5	Zfish	PMID:23499359
Biological Process	GO:1901201	regulation of extracellular matrix assembly	Has2	IMP		Rat	PMID:27094859\|RGD:12910548
Biological Process	GO:0070295	renal water absorption	Has2	IEP		Rat	PMID:19635555\|RGD:8553259
Biological Process	GO:0001756	somitogenesis	has2	IMP		Zfish	PMID:14729574
Biological Process	GO:0001570	vasculogenesis	Has2	IMP		Mouse	MGI:MGI:1861536\|PMID:10930438

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.