Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HAVCR2
  • Mouse genes Havcr2
  • Rat genes Havcr2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Havcr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HAVCR2	IPI	UniProtKB:P13688	Human	PMID:25363763
Molecular Function	GO:0005515	protein binding	HAVCR2	IPI	UniProtKB:Q8N2M4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HAVCR2	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HAVCR2	IDA		Human	PMID:34110282
Molecular Function	GO:0005515	protein binding	Havcr2	IPI	UniProtKB:O08573-2	Mouse	MGI:MGI:3662972|PMID:16286920
Molecular Function	GO:0005515	protein binding	Havcr2	IPI	UniProtKB:P31809	Mouse	MGI:MGI:5614156|PMID:25363763
Molecular Function	GO:0005515	protein binding	Havcr2	IPI	UniProtKB:P63158	Mouse	MGI:MGI:5437532|PMID:22842346
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	HAVCR2	IDA		Human	PMID:34110282
Cellular Component	GO:0009986	cell surface	HAVCR2	IDA		Human	PMID:25363763
Cellular Component	GO:0009986	cell surface	Havcr2	IDA		Mouse	MGI:MGI:5688819|PMID:25065622
Cellular Component	GO:0009986	cell surface	Havcr2	IDA		Rat	PMID:24508263|RGD:9686116
Cellular Component	GO:0005769	early endosome	Havcr2	IDA		Mouse	MGI:MGI:5437532|PMID:22842346
Cellular Component	GO:0001772	immunological synapse	Havcr2	IDA		Mouse	MGI:MGI:5705214|PMID:24337741
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Havcr2	IDA		Mouse	MGI:MGI:5705210|PMID:25337993
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Havcr2	IMP		Mouse	MGI:MGI:5568873|PMID:24567532
Biological Process	GO:0002281	macrophage activation involved in immune response	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0060135	maternal process involved in female pregnancy	HAVCR2	IDA		Human	PMID:25578313
Biological Process	GO:0060135	maternal process involved in female pregnancy	Havcr2	IDA		Mouse	MGI:MGI:5644095|PMID:25578313
Biological Process	GO:0002519	natural killer cell tolerance induction	HAVCR2	IMP	UniProtKB:O00182	Human	PMID:25578313
Biological Process	GO:1900425	negative regulation of defense response to bacterium	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0010629	negative regulation of gene expression	HAVCR2	IMP	UniProtKB:O00182	Human	PMID:25578313
Biological Process	GO:0071656	negative regulation of granulocyte colony-stimulating factor production	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0002838	negative regulation of immune response to tumor cell	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:2000521	negative regulation of immunological synapse formation	Havcr2	IMP		Mouse	MGI:MGI:5705214|PMID:24337741
Biological Process	GO:0045824	negative regulation of innate immune response	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0032687	negative regulation of interferon-alpha production	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0032703	negative regulation of interleukin-2 production	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Havcr2	IMP		Mouse	MGI:MGI:2679123|PMID:14556006
Biological Process	GO:0032712	negative regulation of interleukin-3 production	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0030886	negative regulation of myeloid dendritic cell activation	HAVCR2	IMP		Human	PMID:22842346
Biological Process	GO:0032815	negative regulation of natural killer cell activation	Havcr2	IMP		Mouse	MGI:MGI:5705210|PMID:25337993
Biological Process	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	HAVCR2	IMP		Human	PMID:22842346
Biological Process	GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0042130	negative regulation of T cell proliferation	Havcr2	IMP		Mouse	MGI:MGI:2679123|PMID:14556006
Biological Process	GO:0002826	negative regulation of T-helper 1 type immune response	Havcr2	IMP		Mouse	MGI:MGI:2679123|PMID:14556006
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	HAVCR2	IMP	UniProtKB:O00182	Human	PMID:25578313
Biological Process	GO:0032480	negative regulation of type I interferon production	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0032689	negative regulation of type II interferon production	HAVCR2	IDA		Human	PMID:26492563
Biological Process	GO:0032689	negative regulation of type II interferon production	Havcr2	IMP		Mouse	MGI:MGI:2679123|PMID:14556006
Biological Process	GO:0032722	positive regulation of chemokine production	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0001819	positive regulation of cytokine production	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:1900426	positive regulation of defense response to bacterium	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Havcr2	IDA		Mouse	MGI:MGI:3763563|PMID:18006747
Biological Process	GO:0045089	positive regulation of innate immune response	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0032732	positive regulation of interleukin-1 production	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0032753	positive regulation of interleukin-4 production	HAVCR2	IMP	UniProtKB:O00182	Human	PMID:25578313
Biological Process	GO:0043032	positive regulation of macrophage activation	Havcr2	IMP	UniProtKB:O08573	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Havcr2	IDA		Mouse	MGI:MGI:3763563|PMID:18006747
Biological Process	GO:0042102	positive regulation of T cell proliferation	Havcr2	IMP		Mouse	MGI:MGI:5568873|PMID:24567532
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	HAVCR2	IMP		Human	PMID:18006747
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Havcr2	IMP		Mouse	MGI:MGI:3763563|PMID:18006747
Biological Process	GO:0032729	positive regulation of type II interferon production	Havcr2	IMP		Mouse	MGI:MGI:5568873|PMID:24567532
Biological Process	GO:0002652	regulation of tolerance induction dependent upon immune response	Havcr2	IMP		Mouse	MGI:MGI:2679123|PMID:14556006
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0034154	toll-like receptor 7 signaling pathway	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	Havcr2	IMP		Mouse	MGI:MGI:5437532|PMID:22842346

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern