Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HBA1,HBA2
  • Mouse genes Hba-a1
  • Rat genes Hba-a1,Hba-a2,Hba-a3
  • Zfish genes hbaa2,hbae1.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hba-a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Hba-a1	IDA		Rat	PMID:11004532|RGD:1599362
Molecular Function	GO:0001664	G protein-coupled receptor binding	Hba-a2	IDA		Rat	PMID:18077343|RGD:152025530
Molecular Function	GO:0001664	G protein-coupled receptor binding	Hba-a1	IDA		Rat	PMID:18077343|RGD:152025530
Molecular Function	GO:0031720	haptoglobin binding	HBA1	IDA		Human	PMID:19740759
Molecular Function	GO:0020037	heme binding	Hba-a3	IDA		Rat	PMID:6284505|RGD:1599377
Molecular Function	GO:0043177	organic acid binding	Hba-a3	IPI	CHEBI:17826	Rat	PMID:15606151|RGD:1599369
Molecular Function	GO:0019825	oxygen binding	Hba-a3	IDA		Rat	PMID:6284505|RGD:1599377
Molecular Function	GO:0004601	peroxidase activity	HBA1	IDA		Human	PMID:19740759
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:10390349
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:10930828
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P02100	Human	PMID:11159543
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:11724557
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P03129	Human	PMID:12072504
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:1552945
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:Q9NZD4	Human	PMID:15550245
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:15835899
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P00387	Human	PMID:23123858
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P29474	Human	PMID:23123858
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:Q9NZD4	Human	PMID:25156257
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:Q2TAC2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:28665412
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:30833564
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P02042	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P02100	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P09105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P69892	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:6683087
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:9441940
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:9830011
Molecular Function	GO:0005515	protein binding	HBA1	IPI	UniProtKB:P68871	Human	PMID:9894000
Molecular Function	GO:0005515	protein binding	Hba-a2	IPI	UniProtKB:P03129	Rat	PMID:12072504|RGD:8553923
Molecular Function	GO:0005515	protein binding	Hba-a1	IPI	UniProtKB:P03129	Rat	PMID:12072504|RGD:8553923
Molecular Function	GO:0044877	protein-containing complex binding	Hba-a3	IDA		Rat	PMID:4429672|RGD:1599378
Cellular Component	GO:0072562	blood microparticle	HBA1	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	HBA1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HBA1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	HBA1	IDA		Human	PMID:21805676
Cellular Component	GO:0031838	haptoglobin-hemoglobin complex	HBA1	IDA		Human	PMID:19740759
Cellular Component	GO:0005833	hemoglobin complex	HBA1	IPI		Human	PMID:15449937
Cellular Component	GO:0005833	hemoglobin complex	HBA1	IPI		Human	PMID:16765986
Cellular Component	GO:0005833	hemoglobin complex	HBA1	IPI		Human	PMID:881729
Cellular Component	GO:0005833	hemoglobin complex	HBA1	IPI		Human	PMID:9665850
Cellular Component	GO:0005833	hemoglobin complex	HBA1	IDA		Human	PMID:19740759
Cellular Component	GO:0005833	hemoglobin complex	Hba-a1	IPI		Mouse	MGI:MGI:7260088|PMID:33830076
Cellular Component	GO:0005833	hemoglobin complex	Hba-a3	IDA		Rat	PMID:4429672|RGD:1599378
Cellular Component	GO:0016020	membrane	HBA1	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Hba-a1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0045202	synapse	Hba-a1	IDA		Rat	PMID:21428213|RGD:10450508
Biological Process	GO:0048821	erythrocyte development	Hba-a1	IGI	MGI:MGI:96016	Mouse	PMID:7550311
Biological Process	GO:0042744	hydrogen peroxide catabolic process	HBA1	IDA		Human	PMID:19740759
Biological Process	GO:0001701	in utero embryonic development	Hba-a1	IGI	MGI:MGI:96016	Mouse	PMID:7550311
Biological Process	GO:0045776	negative regulation of blood pressure	Hba-a1	IDA		Rat	PMID:15962106|RGD:1599364
Biological Process	GO:0030185	nitric oxide transport	HBA1	IDA		Human	PMID:8292032
Biological Process	GO:0015671	oxygen transport	HBA1	IDA		Human	PMID:11159543
Biological Process	GO:0015671	oxygen transport	HBA1	IDA		Human	PMID:11307949
Biological Process	GO:0015671	oxygen transport	HBA1	IMP		Human	PMID:7518430
Biological Process	GO:0010942	positive regulation of cell death	HBA1	IDA		Human	PMID:19740759
Biological Process	GO:0051930	regulation of sensory perception of pain	Hba-a1	IDA		Rat	PMID:15962106|RGD:1599364
Biological Process	GO:0009617	response to bacterium	Hba-a1	IEP		Mouse	PMID:23012479
Biological Process	GO:0032355	response to estradiol	Hba-a2	IEP		Rat	PMID:20534718|RGD:7248620
Biological Process	GO:0042542	response to hydrogen peroxide	HBA1	IDA		Human	PMID:19740759
Biological Process	GO:0035634	response to stilbenoid	Hba-a1	IEP		Mouse	MGI:MGI:4943399|PMID:17086191

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern