Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HBB,HBD
  • Mouse genes Hbb-b2
  • Rat genes Hbb,Hbb-bs,LOC100134871
  • Zfish genes hbba2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hbb-b2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031720	haptoglobin binding	HBB	IDA		Human	PMID:19740759
Molecular Function	GO:0031721	hemoglobin alpha binding	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Molecular Function	GO:0031722	hemoglobin beta binding	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Molecular Function	GO:0030492	hemoglobin binding	HBB	IDA		Human	PMID:1512262
Molecular Function	GO:0019825	oxygen binding	HBB	IDA		Human	PMID:11747442
Molecular Function	GO:0019825	oxygen binding	HBB	IDA		Human	PMID:28066926
Molecular Function	GO:0019825	oxygen binding	Hbb-b2	IMP		Mouse	PMID:21281810
Molecular Function	GO:0019825	oxygen binding	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Molecular Function	GO:0004601	peroxidase activity	HBB	IDA		Human	PMID:19740759
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:P02008	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:P09105	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:P02008	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:P09105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:P69905	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:O00746	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HBD	IPI	UniProtKB:Q8TAB7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:10390349
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:10930828
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P02008	Human	PMID:11159543
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:11724557
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:1552945
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:15835899
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P02008	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:28665412
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:30833564
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P02008	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P02008	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P09105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:Q6B0K9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P02008	Human	PMID:6683087
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:6683087
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:9441940
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:9830011
Molecular Function	GO:0005515	protein binding	HBB	IPI	UniProtKB:P69905	Human	PMID:9894000
Molecular Function	GO:0005515	protein binding	Hbb-b2	IPI	PR:Q65Z93	Mouse	PMID:34354145
Molecular Function	GO:0044877	protein-containing complex binding	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Cellular Component	GO:0072562	blood microparticle	HBD	HDA		Human	PMID:22516433
Cellular Component	GO:0072562	blood microparticle	HBB	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	HBB	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HBB	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	HBB	IDA		Human	PMID:21805676
Cellular Component	GO:0031838	haptoglobin-hemoglobin complex	HBB	IDA		Human	PMID:19740759
Cellular Component	GO:0005833	hemoglobin complex	HBD	IPI		Human	PMID:15449937
Cellular Component	GO:0005833	hemoglobin complex	HBB	IPI		Human	PMID:16765986
Cellular Component	GO:0005833	hemoglobin complex	HBB	IPI		Human	PMID:24100324
Cellular Component	GO:0005833	hemoglobin complex	HBB	IPI		Human	PMID:8114096
Cellular Component	GO:0005833	hemoglobin complex	HBB	IDA		Human	PMID:19740759
Cellular Component	GO:0005833	hemoglobin complex	Hbb-b2	IMP	MGI:MGI:1857296	Mouse	PMID:8524813
Cellular Component	GO:0005833	hemoglobin complex	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Biological Process	GO:0048821	erythrocyte development	Hbb-b2	IGI	MGI:MGI:96021	Mouse	PMID:8524813
Biological Process	GO:0006749	glutathione metabolic process	Hbb	IDA		Rat	PMID:19963409|RGD:2325281
Biological Process	GO:0042744	hydrogen peroxide catabolic process	HBB	IDA		Human	PMID:19740759
Biological Process	GO:0030099	myeloid cell differentiation	Hbb-b2	IMP		Mouse	PMID:21281810
Biological Process	GO:0030185	nitric oxide transport	HBB	IDA		Human	PMID:8292032
Biological Process	GO:0015671	oxygen transport	HBD	IDA		Human	PMID:11307949
Biological Process	GO:0015671	oxygen transport	HBB	IDA		Human	PMID:11159543
Biological Process	GO:0015671	oxygen transport	HBB	IMP		Human	PMID:7518430
Biological Process	GO:0015671	oxygen transport	Hbb	IDA		Rat	PMID:242324|RGD:1600914
Biological Process	GO:0070527	platelet aggregation	HBB	HMP		Human	PMID:23382103
Biological Process	GO:0010942	positive regulation of cell death	HBB	IDA		Human	PMID:19740759
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	Hbb-b2	IMP		Mouse	PMID:21281810
Biological Process	GO:0045646	regulation of erythrocyte differentiation	Hbb-b2	IMP		Mouse	PMID:21281810
Biological Process	GO:0070293	renal absorption	HBB	IMP		Human	PMID:18465053
Biological Process	GO:0070293	renal absorption	HBB	IMP		Human	PMID:18974585
Biological Process	GO:0042542	response to hydrogen peroxide	HBB	IDA		Human	PMID:19740759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern