Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCK
  • Mouse genes Hck
  • Rat genes Hck
  • Zfish genes hck
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hck

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008289	lipid binding	HCK	EXP		Human	PMID:31877324
Molecular Function	GO:0001784	phosphotyrosine residue binding	HCK	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P12504	Human	PMID:11278465
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07666	Human	PMID:11278465
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q13444	Human	PMID:11741929
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:O43516	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P42768	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07666	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07889	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q92556	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q9ULH1	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:O92972	Human	PMID:14993658
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P27958	Human	PMID:14993658
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:O92972	Human	PMID:15784897
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P27958	Human	PMID:15784897
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q13177	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q13444	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q90VU7	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q9ULH1	Human	PMID:16636290
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07666	Human	PMID:17141806
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07889	Human	PMID:17141806
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P03406	Human	PMID:18042718
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P42768	Human	PMID:19234535
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q8WUM4	Human	PMID:20670214
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07666	Human	PMID:22641034
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q8WUM4	Human	PMID:22641034
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P00533	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q07889	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P09917	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:O14672	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q9HD26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q9H6R7	Human	PMID:25469238
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:O43184	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:Q13444	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P59046	Human	PMID:32226298
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	HCK	IPI	UniProtKB:P03406	Human	PMID:7859737
Molecular Function	GO:0005515	protein binding	Hck	IPI	UniProtKB:P42768	Mouse	MGI:MGI:5486569|PMID:12235133
Molecular Function	GO:0004713	protein tyrosine kinase activity	HCK	IMP		Human	PMID:10092522
Molecular Function	GO:0004713	protein tyrosine kinase activity	HCK	EXP		Human	PMID:10861086
Molecular Function	GO:0004713	protein tyrosine kinase activity	HCK	EXP		Human	PMID:16921024
Cellular Component	GO:0005884	actin filament	HCK	IDA		Human	PMID:15998323
Cellular Component	GO:0005901	caveola	HCK	IDA		Human	PMID:7791757
Cellular Component	GO:0005829	cytosol	HCK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	HCK	IMP		Human	PMID:11904303
Cellular Component	GO:0005925	focal adhesion	HCK	IMP		Human	PMID:11904303
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HCK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	HCK	IDA		Human	PMID:15998323
Cellular Component	GO:0005886	plasma membrane	HCK	IDA		Human	GO_REF:0000052
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Hck	IGI	MGI:MGI:95527	Mouse	PMID:8125254
Biological Process	GO:0051179	localization	HCK	EXP		Human	PMID:31877324
Biological Process	GO:0043066	negative regulation of apoptotic process	HCK	IMP		Human	PMID:17535448
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	HCK	IMP		Human	PMID:10092522
Biological Process	GO:0006909	phagocytosis	Hck	IMP	MGI:MGI:2384049	Mouse	PMID:8125254
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	HCK	IMP		Human	PMID:11904303
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	HCK	IDA		Human	PMID:15998323
Biological Process	GO:0008284	positive regulation of cell population proliferation	HCK	IMP		Human	PMID:10092522
Biological Process	GO:0046777	protein autophosphorylation	HCK	IMP		Human	PMID:10092522
Biological Process	GO:0008360	regulation of cell shape	HCK	IMP		Human	PMID:10092522
Biological Process	GO:0008360	regulation of cell shape	HCK	IMP		Human	PMID:11904303
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	HCK	IMP		Human	PMID:17535448
Biological Process	GO:0050764	regulation of phagocytosis	HCK	IMP		Human	PMID:11904303
Biological Process	GO:0071801	regulation of podosome assembly	HCK	IDA		Human	PMID:15998323

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern