Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCN1
  • Mouse genes Hcn1
  • Rat genes Hcn1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	HCN1	IDA		Human	PMID:28086084
Molecular Function	GO:0030552	cAMP binding	Hcn1	IDA		Mouse	MGI:MGI:5520040|PMID:22006928
Molecular Function	GO:0042802	identical protein binding	Hcn1	IPI	UniProtKB:O88704	Mouse	MGI:MGI:5520040|PMID:22006928
Molecular Function	GO:0042802	identical protein binding	Hcn1	IDA		Rat	PMID:19008224|RGD:9686142
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	Hcn1	IMP		Mouse	MGI:MGI:5520040|PMID:22006928
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	Hcn1	IDA		Mouse	PMID:30886335
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	Hcn1	IDA		Mouse	PMID:21358644
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	Hcn1	EXP		Mouse	PMID:21358644
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	Hcn1	IMP		Mouse	PMID:21358644
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Hcn1	IDA		Rat	PMID:22948144|RGD:9686140
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Hcn1	IDA		Rat	PMID:22948144|RGD:9686140
Molecular Function	GO:0005515	protein binding	HCN1	IPI	UniProtKB:Q4ACU6-1	Human	PMID:26966193
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	PR:Q8C437	Mouse	PMID:15564593
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	PR:Q8BQU7	Mouse	PMID:30886335
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	RGD:620689	Rat	PMID:17988239|RGD:9686135
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	RGD:1590969	Rat	PMID:19008224|RGD:9686142
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	RGD:71065	Rat	PMID:21456027|RGD:9686442
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	RGD:1590969	Rat	PMID:22948144|RGD:9686140
Molecular Function	GO:0005515	protein binding	Hcn1	IPI	RGD:735047	Rat	PMID:24451387|RGD:9686374
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	HCN1	IDA		Human	PMID:28086084
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN1	IMP		Human	PMID:22748890
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Hcn1	IMP		Mouse	MGI:MGI:5520040|PMID:22006928
Molecular Function	GO:0005248	voltage-gated sodium channel activity	HCN1	IMP		Human	PMID:22748890
Cellular Component	GO:0097440	apical dendrite	Hcn1	IDA		Rat	PMID:19458150|RGD:9686429
Cellular Component	GO:0030424	axon	Hcn1	IDA		Mouse	PMID:15479642
Cellular Component	GO:0030424	axon	Hcn1	IDA		Rat	PMID:17439493|RGD:2316636
Cellular Component	GO:0043679	axon terminus	Hcn1	IDA		Rat	PMID:17460082|RGD:9686366
Cellular Component	GO:0016323	basolateral plasma membrane	Hcn1	IDA		Rat	PMID:11675786|RGD:9686443
Cellular Component	GO:0009986	cell surface	Hcn1	IDA		Rat	PMID:20215108|RGD:9686144
Cellular Component	GO:0005737	cytoplasm	Hcn1	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0030425	dendrite	Hcn1	IDA		Mouse	PMID:15564593
Cellular Component	GO:0030425	dendrite	Hcn1	IDA		Rat	PMID:24451387|RGD:9686374
Cellular Component	GO:0032590	dendrite membrane	Hcn1	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0043198	dendritic shaft	Hcn1	IDA		Rat	PMID:17439493|RGD:2316636
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	IDA		Mouse	PMID:21358644
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	EXP		Mouse	PMID:21358644
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	IMP		Mouse	PMID:21358644
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	IDA		Mouse	PMID:18093528
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	IMP		Mouse	PMID:18093528
Cellular Component	GO:0098978	glutamatergic synapse	Hcn1	EXP		Mouse	PMID:18093528
Cellular Component	GO:0098855	HCN channel complex	HCN1	IDA		Human	PMID:28086084
Cellular Component	GO:0098855	HCN channel complex	Hcn1	IPI		Mouse	MGI:MGI:5520040|PMID:22006928
Cellular Component	GO:0043025	neuronal cell body	Hcn1	IDA		Rat	PMID:24451387|RGD:9686374
Cellular Component	GO:0005886	plasma membrane	HCN1	IDA		Human	PMID:22748890
Cellular Component	GO:0005886	plasma membrane	HCN1	IDA		Human	PMID:28086084
Cellular Component	GO:0005886	plasma membrane	HCN1	IDA		Human	PMID:30351409
Cellular Component	GO:0005886	plasma membrane	Hcn1	IMP		Mouse	MGI:MGI:5520040|PMID:22006928
Cellular Component	GO:0005886	plasma membrane	Hcn1	IDA		Mouse	PMID:30886335
Cellular Component	GO:0005886	plasma membrane	Hcn1	IDA		Rat	PMID:18424000|RGD:9686393
Cellular Component	GO:0045211	postsynaptic membrane	Hcn1	IDA		Mouse	PMID:21358644
Cellular Component	GO:0048787	presynaptic active zone membrane	Hcn1	IDA		Mouse	PMID:21358644
Cellular Component	GO:0036477	somatodendritic compartment	Hcn1	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0045202	synapse	Hcn1	IDA		Rat	PMID:17439493|RGD:2316636
Biological Process	GO:0007568	aging	Hcn1	IEP		Rat	PMID:19458150|RGD:9686429
Biological Process	GO:0045176	apical protein localization	Hcn1	IMP	MGI:MGI:2686950	Mouse	PMID:15564593
Biological Process	GO:0071320	cellular response to cAMP	HCN1	IDA		Human	PMID:16043489
Biological Process	GO:0071320	cellular response to cAMP	HCN1	IDA		Human	PMID:22748890
Biological Process	GO:0071320	cellular response to cAMP	HCN1	IMP		Human	PMID:28086084
Biological Process	GO:0071320	cellular response to cAMP	Hcn1	IDA		Mouse	MGI:MGI:5520040|PMID:22006928
Biological Process	GO:0071320	cellular response to cAMP	Hcn1	IMP		Mouse	MGI:MGI:5520040|PMID:22006928
Biological Process	GO:0035458	cellular response to interferon-beta	Hcn1	IEP		Rat	PMID:23042740|RGD:9686391
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Hcn1	IDA		Mouse	PMID:30886335
Biological Process	GO:0006954	inflammatory response	Hcn1	IEP		Rat	PMID:19409968|RGD:2316615
Biological Process	GO:0042711	maternal behavior	Hcn1	IEP		Rat	PMID:16820024|RGD:9686416
Biological Process	GO:0045759	negative regulation of action potential	Hcn1	IMP		Rat	PMID:22884333|RGD:9686419
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Hcn1	IDA		Mouse	MGI:MGI:5006896|PMID:21358644
Biological Process	GO:0019228	neuronal action potential	Hcn1	IDA		Mouse	PMID:30886335
Biological Process	GO:2001259	positive regulation of cation channel activity	Hcn1	IDA		Rat	PMID:20806410|RGD:9686372
Biological Process	GO:1902632	positive regulation of membrane hyperpolarization	Hcn1	IMP		Rat	PMID:30408474|RGD:26923909
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN1	IMP		Human	PMID:22748890
Biological Process	GO:0071805	potassium ion transmembrane transport	Hcn1	IMP		Mouse	MGI:MGI:5520040|PMID:22006928
Biological Process	GO:0051289	protein homotetramerization	HCN1	IDA		Human	PMID:28086084
Biological Process	GO:0003254	regulation of membrane depolarization	HCN1	IDA		Human	PMID:16043489
Biological Process	GO:0003254	regulation of membrane depolarization	Hcn1	IDA		Rat	PMID:20806410|RGD:9686372
Biological Process	GO:1902630	regulation of membrane hyperpolarization	Hcn1	IMP		Rat	PMID:22884333|RGD:9686419
Biological Process	GO:0042391	regulation of membrane potential	HCN1	IMP		Human	PMID:22748890
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Hcn1	EXP		Mouse	PMID:18093528
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Hcn1	IDA		Mouse	PMID:18093528
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Hcn1	IMP		Mouse	PMID:18093528
Biological Process	GO:0051592	response to calcium ion	Hcn1	IDA		Rat	PMID:19008224|RGD:9686142
Biological Process	GO:0072718	response to cisplatin	Hcn1	IEP		Rat	PMID:19584356|RGD:2316614
Biological Process	GO:1902065	response to L-glutamate	Hcn1	IEP		Rat	PMID:20215108|RGD:9686144
Biological Process	GO:0046549	retinal cone cell development	Hcn1	IMP		Mouse	PMID:21052544
Biological Process	GO:0035725	sodium ion transmembrane transport	HCN1	IMP		Human	PMID:22748890

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern