Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCN2
  • Mouse genes Hcn2
  • Rat genes Hcn2
  • Zfish genes hcn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	HCN2	IPI	UniProtKB:Q9UL51	Human	PMID:22006928
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	HCN2	IDA		Human	PMID:10228147
Molecular Function	GO:0060090	molecular adaptor activity	Hcn2	IDA		Rat	PMID:15265006|RGD:2316658
Molecular Function	GO:0030165	PDZ domain binding	Hcn2	IPI	RGD:70554|RGD:621855	Rat	PMID:15265006|RGD:2316658
Molecular Function	GO:0005515	protein binding	HCN2	IPI	UniProtKB:Q4ACU6-1	Human	PMID:26966193
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	UniProtKB:P00523	Mouse	MGI:MGI:5508266|PMID:16079136
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	UniProtKB:Q8IYB4-6	Mouse	MGI:MGI:5916860|PMID:25800552
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	PR:Q8C437	Mouse	PMID:15564593
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	RGD:620845	Rat	PMID:15265006|RGD:2316658
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	RGD:71065	Rat	PMID:17553794|RGD:2316629
Molecular Function	GO:0005515	protein binding	Hcn2	IPI	RGD:620688	Rat	PMID:17988239|RGD:9686135
Molecular Function	GO:0044877	protein-containing complex binding	Hcn2	IPI	RGD:620688|RGD:1308941	Rat	PMID:22948144|RGD:9686140
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN2	IDA		Human	PMID:10228147
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN2	IMP		Human	PMID:22748890
Molecular Function	GO:0005248	voltage-gated sodium channel activity	HCN2	IMP		Human	PMID:22748890
Cellular Component	GO:0030424	axon	Hcn2	IDA		Rat	PMID:18668683|RGD:2316618
Cellular Component	GO:0005737	cytoplasm	Hcn2	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0032590	dendrite membrane	Hcn2	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0043198	dendritic shaft	Hcn2	IDA		Rat	PMID:17439493|RGD:2316636
Cellular Component	GO:0098855	HCN channel complex	HCN2	IPI		Human	PMID:22006928
Cellular Component	GO:0098855	HCN channel complex	HCN2	IDA		Human	PMID:10228147
Cellular Component	GO:0098855	HCN channel complex	Hcn2	IPI		Mouse	MGI:MGI:6810787|PMID:12968185
Cellular Component	GO:0016020	membrane	Hcn2	IDA		Mouse	PMID:30886335
Cellular Component	GO:0016020	membrane	Hcn2	IDA		Rat	PMID:15265006|RGD:2316658
Cellular Component	GO:0043025	neuronal cell body	Hcn2	IDA		Rat	PMID:18478257|RGD:2316619
Cellular Component	GO:0005886	plasma membrane	HCN2	IDA		Human	PMID:10228147
Cellular Component	GO:0005886	plasma membrane	HCN2	IDA		Human	PMID:22748890
Cellular Component	GO:0005886	plasma membrane	Hcn2	IDA		Rat	PMID:19409968|RGD:2316615
Cellular Component	GO:0036477	somatodendritic compartment	Hcn2	IDA		Rat	PMID:23324324|RGD:9686375
Cellular Component	GO:0045202	synapse	Hcn2	IDA		Rat	PMID:17439493|RGD:2316636
Biological Process	GO:0007568	aging	Hcn2	IEP		Rat	PMID:17572839|RGD:2316624
Biological Process	GO:0007420	brain development	Hcn2	IEP		Rat	PMID:19587292|RGD:2316613
Biological Process	GO:1904045	cellular response to aldosterone	Hcn2	IEP		Rat	PMID:17644563|RGD:9686437
Biological Process	GO:0071320	cellular response to cAMP	HCN2	IDA		Human	PMID:10228147
Biological Process	GO:0071320	cellular response to cAMP	HCN2	IDA		Human	PMID:22006928
Biological Process	GO:0071320	cellular response to cAMP	HCN2	IDA		Human	PMID:22748890
Biological Process	GO:0071320	cellular response to cAMP	Hcn2	IDA		Mouse	MGI:MGI:6810787|PMID:12968185
Biological Process	GO:0071321	cellular response to cGMP	HCN2	IDA		Human	PMID:22748890
Biological Process	GO:0006954	inflammatory response	Hcn2	IEP		Rat	PMID:19409968|RGD:2316615
Biological Process	GO:1990573	potassium ion import across plasma membrane	HCN2	IDA		Human	PMID:10228147
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN2	IDA		Human	PMID:10228147
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN2	IMP		Human	PMID:22748890
Biological Process	GO:0003254	regulation of membrane depolarization	HCN2	IDA		Human	PMID:16043489
Biological Process	GO:0003254	regulation of membrane depolarization	Hcn2	IDA		Mouse	MGI:MGI:6810787|PMID:12968185
Biological Process	GO:0042391	regulation of membrane potential	HCN2	IMP		Human	PMID:22748890
Biological Process	GO:0042391	regulation of membrane potential	Hcn2	IDA		Mouse	PMID:15564593
Biological Process	GO:0042391	regulation of membrane potential	Hcn2	IGI	MGI:MGI:1916672	Mouse	PMID:15564593
Biological Process	GO:0072718	response to cisplatin	Hcn2	IEP		Rat	PMID:19584356|RGD:2316614
Biological Process	GO:0009725	response to hormone	Hcn2	IEP		Rat	PMID:10488052|RGD:2316678
Biological Process	GO:0009410	response to xenobiotic stimulus	Hcn2	IEP		Rat	PMID:19584356|RGD:2316614
Biological Process	GO:0098719	sodium ion import across plasma membrane	HCN2	IDA		Human	PMID:10228147
Biological Process	GO:0035725	sodium ion transmembrane transport	HCN2	IMP		Human	PMID:22748890

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern