Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCN4
  • Mouse genes Hcn4
  • Rat genes Hcn4
  • Zfish genes hcn4,hcn4l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	HCN4	IPI	UniProtKB:Q9Y3Q4	Human	PMID:22006928
Molecular Function	GO:0042802	identical protein binding	HCN4	IPI	UniProtKB:Q9Y3Q4	Human	PMID:24776929
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	HCN4	IDA		Human	PMID:10228147
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	HCN4	IDA		Human	PMID:12750403
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	HCN4	IDA		Human	PMID:16407510
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	Hcn4	IMP	MGI:MGI:2684538	Mouse	PMID:14657344
Molecular Function	GO:0005515	protein binding	Hcn4	IPI	PR:Q8C437	Mouse	PMID:15564593
Molecular Function	GO:0005515	protein binding	Hcn4	IPI	PR:P51637	Mouse	PMID:19238754
Molecular Function	GO:0005515	protein binding	Hcn4	IPI	RGD:620689	Rat	PMID:17553794|RGD:2316629
Molecular Function	GO:0005515	protein binding	Hcn4	IPI	RGD:620688	Rat	PMID:21456027|RGD:9686442
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN4	IDA		Human	PMID:16407510
Molecular Function	GO:0005249	voltage-gated potassium channel activity	HCN4	IMP		Human	PMID:22748890
Molecular Function	GO:0086041	voltage-gated potassium channel activity involved in SA node cell action potential depolarization	HCN4	IMP		Human	PMID:16407510
Molecular Function	GO:0005248	voltage-gated sodium channel activity	HCN4	IMP		Human	PMID:22748890
Cellular Component	GO:0030424	axon	Hcn4	IDA		Mouse	PMID:23172916
Cellular Component	GO:0016323	basolateral plasma membrane	Hcn4	IDA		Rat	PMID:11675786|RGD:9686443
Cellular Component	GO:0098855	HCN channel complex	HCN4	IPI		Human	PMID:20829353
Cellular Component	GO:0098855	HCN channel complex	HCN4	IDA		Human	PMID:10228147
Cellular Component	GO:0098855	HCN channel complex	HCN4	IDA		Human	PMID:16407510
Cellular Component	GO:0043005	neuron projection	Hcn4	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0043025	neuronal cell body	Hcn4	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HCN4	IDA		Human	PMID:12750403
Cellular Component	GO:0005886	plasma membrane	HCN4	IDA		Human	PMID:12750403
Cellular Component	GO:0005886	plasma membrane	HCN4	IDA		Human	PMID:16407510
Cellular Component	GO:0005886	plasma membrane	HCN4	IDA		Human	PMID:22748890
Cellular Component	GO:0005886	plasma membrane	Hcn4	IDA		Rat	PMID:14991560|RGD:9686394
Cellular Component	GO:0043195	terminal bouton	Hcn4	IDA		Rat	PMID:12786975|RGD:1299239
Biological Process	GO:1904045	cellular response to aldosterone	Hcn4	IEP		Rat	PMID:17644563|RGD:9686437
Biological Process	GO:0071320	cellular response to cAMP	HCN4	IDA		Human	PMID:12750403
Biological Process	GO:0071320	cellular response to cAMP	HCN4	IDA		Human	PMID:16043489
Biological Process	GO:0071320	cellular response to cAMP	HCN4	IDA		Human	PMID:16407510
Biological Process	GO:0071320	cellular response to cAMP	HCN4	IDA		Human	PMID:22748890
Biological Process	GO:0071321	cellular response to cGMP	HCN4	IDA		Human	PMID:22748890
Biological Process	GO:0060047	heart contraction	hcn4	IMP	ZFIN:ZDB-MRPHLNO-180312-1	Zfish	PMID:28803248
Biological Process	GO:0001701	in utero embryonic development	Hcn4	IMP	MGI:MGI:2684538	Mouse	PMID:14657344
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	HCN4	IMP		Human	PMID:16407510
Biological Process	GO:0006812	monoatomic cation transport	HCN4	IDA		Human	PMID:12750403
Biological Process	GO:0006812	monoatomic cation transport	Hcn4	IMP	MGI:MGI:2684538	Mouse	PMID:14657344
Biological Process	GO:1990573	potassium ion import across plasma membrane	HCN4	IDA		Human	PMID:10228147
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN4	IDA		Human	PMID:16407510
Biological Process	GO:0071805	potassium ion transmembrane transport	HCN4	IMP		Human	PMID:22748890
Biological Process	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	HCN4	IMP		Human	PMID:16407510
Biological Process	GO:0055117	regulation of cardiac muscle contraction	HCN4	IMP		Human	PMID:12750403
Biological Process	GO:0008016	regulation of heart contraction	Hcn4	IMP	MGI:MGI:2684538	Mouse	PMID:14657344
Biological Process	GO:0002027	regulation of heart rate	HCN4	IMP		Human	PMID:16407510
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	HCN4	IMP		Human	PMID:12750403
Biological Process	GO:0003254	regulation of membrane depolarization	HCN4	IDA		Human	PMID:12750403
Biological Process	GO:0003254	regulation of membrane depolarization	HCN4	IDA		Human	PMID:16043489
Biological Process	GO:0042391	regulation of membrane potential	HCN4	IMP		Human	PMID:22748890
Biological Process	GO:0072718	response to cisplatin	Hcn4	IEP		Rat	PMID:19584356|RGD:2316614
Biological Process	GO:0086015	SA node cell action potential	HCN4	IMP		Human	PMID:12750403
Biological Process	GO:0098719	sodium ion import across plasma membrane	HCN4	IDA		Human	PMID:10228147
Biological Process	GO:0035725	sodium ion transmembrane transport	HCN4	IMP		Human	PMID:22748890

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern