Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hdac2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HDAC2
- Mouse genes Hdac2
- Rat genes Hdac2
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Molecular Function	GO:0003682	chromatin binding	Hdac2	IDA		Mouse	PMID:17392792
Molecular Function	GO:0031490	chromatin DNA binding	Hdac2	IDA		Mouse	PMID:18458156
Molecular Function	GO:0019213	deacetylase activity	Hdac2	IDA		Rat	PMID:23868068\|RGD:9681716
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Hdac2	IPI	UniProtKB:Q60707	Mouse	MGI:MGI:6710296\|PMID:33795231
Molecular Function	GO:0019899	enzyme binding	HDAC2	IPI	UniProtKB:P11388	Human	PMID:11062478
Molecular Function	GO:0019899	enzyme binding	HDAC2	IPI	UniProtKB:Q9NWT6	Human	PMID:11641274
Molecular Function	GO:0019899	enzyme binding	Hdac2	IPI	UniProtKB:P04797	Mouse	MGI:MGI:4887284\|PMID:20972425
Molecular Function	GO:0019899	enzyme binding	Hdac2	IPI	RGD:1303274	Rat	PMID:15632075\|RGD:1601090
Molecular Function	GO:0031072	heat shock protein binding	Hdac2	IDA		Rat	PMID:18849323\|RGD:2306446
Molecular Function	GO:0004407	histone deacetylase activity	HDAC2	IDA		Human	PMID:16642021
Molecular Function	GO:0004407	histone deacetylase activity	HDAC2	IDA		Human	PMID:28497810
Molecular Function	GO:0004407	histone deacetylase activity	Hdac2	IDA		Mouse	MGI:MGI:6867113\|PMID:30279482
Molecular Function	GO:0004407	histone deacetylase activity	Hdac2	IDA		Mouse	MGI:MGI:5567917\|PMID:15226430
Molecular Function	GO:0004407	histone deacetylase activity	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Molecular Function	GO:0004407	histone deacetylase activity	Hdac2	IDA		Mouse	PMID:12975471
Molecular Function	GO:0004407	histone deacetylase activity	Hdac2	IGI	MGI:MGI:1916782	Mouse	PMID:12975471
Molecular Function	GO:0042826	histone deacetylase binding	HDAC2	IPI	UniProtKB:Q8N108	Human	PMID:28046085
Molecular Function	GO:0042826	histone deacetylase binding	HDAC2	IPI	UniProtKB:Q8N344	Human	PMID:28046085
Molecular Function	GO:0160009	histone decrotonylase activity	HDAC2	IDA		Human	PMID:28497810
Molecular Function	GO:0160009	histone decrotonylase activity	Hdac2	IDA		Mouse	MGI:MGI:6867113\|PMID:30279482
Molecular Function	GO:0034739	histone H4K16 deacetylase activity	Hdac2	IMP		Mouse	MGI:MGI:5619732\|PMID:23516383
Molecular Function	GO:0035851	Krueppel-associated box domain binding	Hdac2	IPI	UniProtKB:E9QAG8	Mouse	MGI:MGI:5543890\|PMID:22391310
Molecular Function	GO:0035851	Krueppel-associated box domain binding	Hdac2	IPI	UniProtKB:E9QAG8	Mouse	MGI:MGI:5526931\|PMID:21177534
Molecular Function	GO:0051059	NF-kappaB binding	HDAC2	IPI	UniProtKB:Q04206	Human	PMID:17785205
Molecular Function	GO:0031492	nucleosomal DNA binding	HDAC2	HDA		Human	PMID:16217013
Molecular Function	GO:1990841	promoter-specific chromatin binding	Hdac2	IDA		Rat	PMID:21586557\|RGD:7241147
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q02880	Human	PMID:11062478
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P29590-5	Human	PMID:11259576
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P40337	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:11739383
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9UER7	Human	PMID:12140263
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q02447	Human	PMID:12176973
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P51610	Human	PMID:12670868
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:O43463	Human	PMID:12711603
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9UIS9	Human	PMID:12711603
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:O88508	Human	PMID:14752048
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96ST3	Human	PMID:16254079
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P48382	Human	PMID:16464847
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9HCU9	Human	PMID:16919237
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9C0K0	Human	PMID:17245431
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P06748	Human	PMID:17318229
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q09028	Human	PMID:17827154
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:17956988
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13127	Human	PMID:17984088
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:18451879
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96EP1	Human	PMID:19182791
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q63HK5	Human	PMID:19343227
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P35222,UniProtKB:Q13547,UniProtKB:Q8NEU8,UniProtKB:Q9UKG1	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P35222,UniProtKB:Q13547,UniProtKB:Q9UKG1	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P17542	Human	PMID:19497860
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q01664	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:19703393
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547,UniProtKB:Q96ST3,UniProtKB:Q9NRA0,UniProtKB:Q9UBB5	Human	PMID:19729656
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:19805145
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P01106	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9HD15	Human	PMID:20398657
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:20651739
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96ST3	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9HCU9	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9H4L7	Human	PMID:21549307
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q5T5X7	Human	PMID:21914818
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:21965678
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:22416134
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q2HR82	Human	PMID:22416134
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96ST3	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9C0K0	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q9HCU9	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:24970816
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q17R98	Human	PMID:25150861
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:O95863	Human	PMID:25314079
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96ST3	Human	PMID:25314079
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:26028330
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P43246	Human	PMID:26221039
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13330	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q96ST3	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q92618	Human	PMID:28947780
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P0DTD1:PRO_0000449623	Human	PMID:32353859
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:P0DTD1:PRO_0000449623	Human	PMID:33060197
Molecular Function	GO:0005515	protein binding	HDAC2	IPI	UniProtKB:Q13547	Human	PMID:9150135
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:E9Q9M8	Mouse	MGI:MGI:6867105\|PMID:34180153
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q62233	Mouse	MGI:MGI:3718714\|PMID:17666527
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q60520\|UniProtKB:Q6ZQ88\|UniProtKB:Q9R190	Mouse	MGI:MGI:4454226\|PMID:20404188
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5567917\|PMID:15226430
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q60520	Mouse	MGI:MGI:3700432\|PMID:15696166
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q60520\|UniProtKB:Q8C796\|UniProtKB:Q9R190	Mouse	MGI:MGI:3844744\|PMID:19424149
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:P11103\|UniProtKB:Q3TKT4	Mouse	MGI:MGI:4819442\|PMID:20596014
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q6ZQ88	Mouse	MGI:MGI:5917228\|PMID:22297846
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:E9QAG8	Mouse	MGI:MGI:5526931\|PMID:21177534
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:A2A8L1	Mouse	MGI:MGI:5559665\|PMID:21931736
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q60972,UniProtKB:Q6ZQ88,UniProtKB:Q9Z0S2	Mouse	MGI:MGI:5817507\|PMID:28053041
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q60520\|UniProtKB:Q9R190	Mouse	MGI:MGI:5548024\|PMID:24240174
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:O09106	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q9R190	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q8R1H0	Mouse	PMID:12975471
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:P13864	Mouse	PMID:10888872
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q8K4B0	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:P97443	Mouse	PMID:11923873
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q08369	Mouse	PMID:20833366
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q60973	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q9ER74	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	UniProtKB:Q05195	Mouse	PMID:11101889
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:P70288	Mouse	PMID:11836251
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	PR:Q924A0	Mouse	PMID:19503085
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	RGD:1359467	Rat	PMID:11516394\|RGD:2306452
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	RGD:1316063	Rat	PMID:17353261\|RGD:2291838
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	RGD:3075	Rat	PMID:24441681\|RGD:9590255
Molecular Function	GO:0005515	protein binding	Hdac2	IPI	RGD:1305902	Rat	PMID:24526703\|RGD:9590211
Molecular Function	GO:0160010	protein de-2-hydroxyisobutyrylase activity	HDAC2	IDA		Human	PMID:29192674
Molecular Function	GO:0033558	protein lysine deacetylase activity	HDAC2	IMP		Human	PMID:19041327
Molecular Function	GO:0033558	protein lysine deacetylase activity	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Molecular Function	GO:0003723	RNA binding	HDAC2	HDA		Human	PMID:22681889
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hdac2	IDA		Mouse	MGI:MGI:5817507\|PMID:28053041
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hdac2	IDA		Mouse	PMID:24137001
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC2	IPI	UniProtKB:P08047	Human	PMID:17827154
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC2	IPI	UniProtKB:Q02086	Human	PMID:17827154
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC2	IPI	UniProtKB:Q96BF6	Human	PMID:22926524
Molecular Function	GO:0043565	sequence-specific DNA binding	HDAC2	IDA		Human	PMID:19276356
Molecular Function	GO:0001222	transcription corepressor binding	Hdac2	IPI	UniProtKB:Q9JJY4	Mouse	MGI:MGI:2178490\|PMID:12007404
Cellular Component	GO:0000785	chromatin	HDAC2	HDA		Human	PMID:16217013
Cellular Component	GO:0000785	chromatin	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Cellular Component	GO:0000785	chromatin	Hdac2	IDA		Mouse	MGI:MGI:2178490\|PMID:12007404
Cellular Component	GO:0000785	chromatin	Hdac2	IDA		Rat	PMID:11516394\|RGD:2306452
Cellular Component	GO:0000781	chromosome, telomeric region	HDAC2	IDA		Human	PMID:25150861
Cellular Component	GO:0005737	cytoplasm	HDAC2	IDA		Human	PMID:24970816
Cellular Component	GO:0005737	cytoplasm	Hdac2	IDA		Rat	PMID:20884991\|RGD:9590244
Cellular Component	GO:0035098	ESC/E(Z) complex	HDAC2	IDA		Human	PMID:20075857
Cellular Component	GO:0000792	heterochromatin	Hdac2	IDA		Mouse	PMID:14643676
Cellular Component	GO:0000792	heterochromatin	Hdac2	IDA		Mouse	PMID:14519686
Cellular Component	GO:0000118	histone deacetylase complex	HDAC2	IDA		Human	PMID:9651585
Cellular Component	GO:0005654	nucleoplasm	HDAC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HDAC2	IDA		Human	PMID:18347167
Cellular Component	GO:0005634	nucleus	HDAC2	IDA		Human	PMID:20523938
Cellular Component	GO:0005634	nucleus	HDAC2	IDA		Human	PMID:24970816
Cellular Component	GO:0005634	nucleus	HDAC2	IDA		Human	PMID:33283408
Cellular Component	GO:0005634	nucleus	Hdac2	IDA		Mouse	MGI:MGI:5817507\|PMID:28053041
Cellular Component	GO:0005634	nucleus	Hdac2	IDA		Mouse	PMID:22770845
Cellular Component	GO:0005634	nucleus	Hdac2	IDA		Mouse	PMID:20720167
Cellular Component	GO:0005634	nucleus	Hdac2	IDA		Rat	PMID:20884991\|RGD:9590244
Cellular Component	GO:0016581	NuRD complex	HDAC2	IDA		Human	PMID:17827154
Cellular Component	GO:0016581	NuRD complex	HDAC2	IDA		Human	PMID:19644445
Cellular Component	GO:0016581	NuRD complex	HDAC2	IDA		Human	PMID:22926524
Cellular Component	GO:0016581	NuRD complex	HDAC2	IDA		Human	PMID:33283408
Cellular Component	GO:0032991	protein-containing complex	HDAC2	HDA		Human	PMID:16217013
Cellular Component	GO:0032991	protein-containing complex	HDAC2	IDA		Human	PMID:28046085
Cellular Component	GO:0005657	replication fork	Hdac2	IDA		Mouse	PMID:10888872
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	Hdac2	IDA		Mouse	MGI:MGI:2178490\|PMID:12007404
Cellular Component	GO:0016580	Sin3 complex	HDAC2	IDA		Human	PMID:14966270
Cellular Component	GO:0016580	Sin3 complex	HDAC2	IDA		Human	PMID:17827154
Cellular Component	GO:0005667	transcription regulator complex	Hdac2	IPI	PR:Q60520	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Hdac2	IPI	PR:Q9QYB2	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Hdac2	IPI	PR:Q60974	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Hdac2	IPI	PR:O09106	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Hdac2	IPI	PR:P05627	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Hdac2	IPI	PR:Q9QYB2	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Hdac2	IPI	PR:O09106	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Hdac2	IPI	PR:Q60520	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Hdac2	IPI	PR:P05627	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Hdac2	IPI	PR:Q60974	Mouse	PMID:17182846
Biological Process	GO:0048149	behavioral response to ethanol	Hdac2	IEP		Rat	PMID:23485013\|RGD:9590265
Biological Process	GO:0055013	cardiac muscle cell development	Hdac2	IMP	MGI:MGI:3712002	Mouse	PMID:17322895
Biological Process	GO:0060038	cardiac muscle cell proliferation	Hdac2	IMP	MGI:MGI:3712002	Mouse	PMID:17322895
Biological Process	GO:0003300	cardiac muscle hypertrophy	Hdac2	IEP		Rat	PMID:19713680\|RGD:9590231
Biological Process	GO:1903351	cellular response to dopamine	Hdac2	IEP		Rat	PMID:15731170\|RGD:9495915
Biological Process	GO:0034605	cellular response to heat	Hdac2	IEP		Rat	PMID:18849323\|RGD:2306446
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Hdac2	IDA		Rat	PMID:19553350\|RGD:9590229
Biological Process	GO:0071300	cellular response to retinoic acid	Hdac2	IEP		Rat	PMID:19486889\|RGD:9590233
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Hdac2	IEP		Rat	PMID:19553350\|RGD:9590229
Biological Process	GO:0035984	cellular response to trichostatin A	Hdac2	IDA		Mouse	PMID:24137001
Biological Process	GO:0006338	chromatin remodeling	HDAC2	HDA		Human	PMID:16217013
Biological Process	GO:0006338	chromatin remodeling	HDAC2	IDA		Human	PMID:9790534
Biological Process	GO:0032922	circadian regulation of gene expression	Hdac2	IDA		Mouse	MGI:MGI:5567917\|PMID:15226430
Biological Process	GO:0016358	dendrite development	Hdac2	IMP		Mouse	MGI:MGI:3811960\|PMID:18754010
Biological Process	GO:0042733	embryonic digit morphogenesis	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0009913	epidermal cell differentiation	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0061029	eyelid development in camera-type eye	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0061198	fungiform papilla formation	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0060789	hair follicle placode formation	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0070828	heterochromatin organization	HDAC2	IMP		Human	PMID:19372552
Biological Process	GO:0021766	hippocampus development	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:19380719
Biological Process	GO:0016575	histone deacetylation	HDAC2	IDA		Human	PMID:10444591
Biological Process	GO:0016575	histone deacetylation	HDAC2	IMP		Human	PMID:19372552
Biological Process	GO:0070932	histone H3 deacetylation	Hdac2	IMP		Rat	PMID:24441681\|RGD:9590255
Biological Process	GO:0043066	negative regulation of apoptotic process	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:19503085
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Hdac2	IMP	MGI:MGI:3712002	Mouse	PMID:17322895
Biological Process	GO:0061000	negative regulation of dendritic spine development	Hdac2	IMP		Rat	PMID:23485013\|RGD:9590265
Biological Process	GO:0043392	negative regulation of DNA binding	Hdac2	IMP		Rat	PMID:21383775\|RGD:9590238
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	HDAC2	IMP		Human	PMID:19041327
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HDAC2	IMP		Human	PMID:19276356
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hdac2	IMP		Rat	PMID:11516394\|RGD:2306452
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:21093383
Biological Process	GO:1902894	negative regulation of miRNA transcription	Hdac2	IGI	UniProtKB:Q6NZM9	Mouse	MGI:MGI:5754467\|PMID:24675724
Biological Process	GO:1902894	negative regulation of miRNA transcription	Hdac2	IMP		Mouse	MGI:MGI:5754467\|PMID:24675724
Biological Process	GO:0010977	negative regulation of neuron projection development	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Biological Process	GO:0010977	negative regulation of neuron projection development	Hdac2	IMP		Rat	PMID:18754010\|RGD:2316161
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	Hdac2	IMP		Rat	PMID:19486889\|RGD:9590233
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	Hdac2	IMP		Rat	PMID:21465537\|RGD:9590234
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC2	IMP		Human	PMID:19041327
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC2	IMP		Human	PMID:19276356
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac2	IGI	MGI:MGI:107157	Mouse	PMID:10431247
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac2	IGI	MGI:MGI:1342291	Mouse	PMID:10431247
Biological Process	GO:0030182	neuron differentiation	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:19380719
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0048709	oligodendrocyte differentiation	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:19503085
Biological Process	GO:0008284	positive regulation of cell population proliferation	HDAC2	IMP		Human	PMID:18347167
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hdac2	IGI	UniProtKB:O09106	Mouse	MGI:MGI:4889029\|PMID:21093383
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hdac2	IMP		Rat	PMID:21465537\|RGD:9590234
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Hdac2	IDA		Mouse	PMID:20833366
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Hdac2	IMP		Rat	PMID:19553350\|RGD:9590229
Biological Process	GO:0032732	positive regulation of interleukin-1 production	Hdac2	IMP		Rat	PMID:22772764\|RGD:9590127
Biological Process	GO:1902437	positive regulation of male mating behavior	Hdac2	IMP		Rat	PMID:21586557\|RGD:7241147
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Hdac2	IGI	MGI:MGI:108086	Mouse	PMID:19503085
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Hdac2	IMP		Rat	PMID:22573687\|RGD:9590148
Biological Process	GO:0045862	positive regulation of proteolysis	HDAC2	IMP		Human	PMID:19041327
Biological Process	GO:2000273	positive regulation of signaling receptor activity	HDAC2	IMP		Human	PMID:18316616
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HDAC2	IMP		Human	PMID:19041327
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HDAC2	IMP		Human	PMID:19372552
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Hdac2	IMP		Rat	PMID:22772764\|RGD:9590127
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Hdac2	IMP		Rat	PMID:21465537\|RGD:9590234
Biological Process	GO:0006476	protein deacetylation	Hdac2	IDA		Mouse	MGI:MGI:3811960\|PMID:18754010
Biological Process	GO:0090311	regulation of protein deacetylation	Hdac2	IGI	MGI:MGI:1916782	Mouse	PMID:20833366
Biological Process	GO:0051896	regulation of protein kinase B signaling	Hdac2	IMP	MGI:MGI:3712002	Mouse	PMID:17322895
Biological Process	GO:0060297	regulation of sarcomere organization	Hdac2	IMP	MGI:MGI:3712002	Mouse	PMID:17322895
Biological Process	GO:0001975	response to amphetamine	Hdac2	IEP		Rat	PMID:22470541\|RGD:9590269
Biological Process	GO:0031000	response to caffeine	Hdac2	IEP		Rat	PMID:24717552\|RGD:9590296
Biological Process	GO:0042220	response to cocaine	Hdac2	IEP		Rat	PMID:16670375\|RGD:2306447
Biological Process	GO:0055093	response to hyperoxia	Hdac2	IEP		Rat	PMID:21905265\|RGD:9590253
Biological Process	GO:0032496	response to lipopolysaccharide	Hdac2	IEP		Rat	PMID:24595367\|RGD:9590254
Biological Process	GO:0035094	response to nicotine	Hdac2	IEP		Rat	PMID:24709674\|RGD:9590295
Biological Process	GO:0009410	response to xenobiotic stimulus	Hdac2	IEP		Rat	PMID:16670375\|RGD:2306447
Biological Process	GO:0009410	response to xenobiotic stimulus	Hdac2	IEP		Rat	PMID:18550052\|RGD:2306220
Biological Process	GO:0009410	response to xenobiotic stimulus	Hdac2	IEP		Rat	PMID:18849323\|RGD:2306446

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.