About   Help   FAQ
Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hdac3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac3
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003682chromatin bindingHDAC3IDAHumanPMID:16569215
Molecular FunctionGO:0003682chromatin bindingHDAC3IDAHumanPMID:18417529
Molecular FunctionGO:0003682chromatin bindingHdac3IDAMousePMID:24565863
Molecular FunctionGO:0003682chromatin bindingHdac3IDAMousePMID:15832170
Molecular FunctionGO:0003682chromatin bindingHdac3IMPRatPMID:22679019|RGD:9590167
Molecular FunctionGO:0031490chromatin DNA bindingHdac3IDAMousePMID:32467224
Molecular FunctionGO:0031490chromatin DNA bindingHdac3IDAMousePMID:18458156
Molecular FunctionGO:0030332cyclin bindingHDAC3IPIUniProtKB:P24385HumanPMID:18417529
Molecular FunctionGO:0019213deacetylase activityHdac3IDARatPMID:23868068|RGD:9681716
Molecular FunctionGO:0003677DNA bindingHdac3IDAMousePMID:15681609
Molecular FunctionGO:0003677DNA bindingHdac3IDAMousePMID:14980219
Molecular FunctionGO:0019899enzyme bindingHDAC3IPIUniProtKB:Q9NWT6HumanPMID:11641274
Molecular FunctionGO:0004857enzyme inhibitor activityHDAC3IDAHumanPMID:25301942
Molecular FunctionGO:0051020GTPase bindingHdac3IPIRGD:619755RatPMID:22679019|RGD:9590167
Molecular FunctionGO:0004407histone deacetylase activityHDAC3IMPHumanPMID:16924111
Molecular FunctionGO:0004407histone deacetylase activityHDAC3IMPHumanPMID:18326024
Molecular FunctionGO:0004407histone deacetylase activityHDAC3IDAHumanPMID:28497810
Molecular FunctionGO:0004407histone deacetylase activityHdac3IDAMouseMGI:MGI:6867113|PMID:30279482
Molecular FunctionGO:0004407histone deacetylase activityHdac3IDAMousePMID:17464331
Molecular FunctionGO:0004407histone deacetylase activityHdac3IMPMousePMID:15832170
Molecular FunctionGO:0004407histone deacetylase activityHdac3IDARatPMID:17079677|RGD:5688291
Molecular FunctionGO:0042826histone deacetylase bindingHDAC3IPIUniProtKB:P56524HumanPMID:10869435
Molecular FunctionGO:0042826histone deacetylase bindingHDAC3IPIUniProtKB:Q9UQL6HumanPMID:10869435
Molecular FunctionGO:0042826histone deacetylase bindingHDAC3IPIUniProtKB:Q9UKV0HumanPMID:12590135
Molecular FunctionGO:0042826histone deacetylase bindingHDAC3IPIUniProtKB:Q9UQL6HumanPMID:23867755
Molecular FunctionGO:0160009histone decrotonylase activityHDAC3IDAHumanPMID:28497810
Molecular FunctionGO:0160009histone decrotonylase activityHdac3IDAMouseMGI:MGI:6867113|PMID:30279482
Molecular FunctionGO:0140678molecular function inhibitor activityHDAC3IDAHumanPMID:34608293
Molecular FunctionGO:0051059NF-kappaB bindingHDAC3IPIUniProtKB:Q04206HumanPMID:17785205
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q8CBD1HumanPMID:11006275
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O75376HumanPMID:11013263
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:11013263
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P29590-5HumanPMID:11259576
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P40337HumanPMID:11641274
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q969S8HumanPMID:11861901
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P54253HumanPMID:15016912
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P08393HumanPMID:15194749
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P60510HumanPMID:15805470
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9UIS9HumanPMID:16432238
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P24385HumanPMID:16461912
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q01101HumanPMID:16569215
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P43356HumanPMID:16847267
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q60974HumanPMID:16917504
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O75496HumanPMID:16924111
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q01664HumanPMID:16924111
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9JIZ5HumanPMID:16924111
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:16924111
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O43823HumanPMID:16980585
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O75376HumanPMID:16980585
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q13227HumanPMID:16980585
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9ULX6HumanPMID:16980585
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:16980585
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P48552HumanPMID:17053781
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P23771HumanPMID:17075044
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O43809HumanPMID:17172643
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q13227HumanPMID:17895379
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q15466HumanPMID:17895379
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q60974HumanPMID:17956988
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9H2U1HumanPMID:18279852
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q6KC79HumanPMID:18854353
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q8N5F7HumanPMID:19409814
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q969R5HumanPMID:20385135
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q14814HumanPMID:21030595
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q8N163HumanPMID:21030595
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O60341HumanPMID:21258344
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O75376HumanPMID:21258344
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q13227HumanPMID:21258344
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:21258344
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:21624135
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q5T5X7HumanPMID:21914818
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P12504HumanPMID:22190034
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:22230954
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P01106HumanPMID:23079660
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q15022HumanPMID:23079660
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O60341HumanPMID:23752268
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:O75376HumanPMID:23752268
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q13227HumanPMID:23752268
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9UKG1HumanPMID:23752268
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:23752268
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:Q9Y618HumanPMID:24449765
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P17861-1HumanPMID:25190803
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P43246HumanPMID:26221039
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P00558HumanPMID:26356530
Molecular FunctionGO:0005515protein bindingHDAC3IPIUniProtKB:P00558-1HumanPMID:26356530
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:Q9Z1E3MouseMGI:MGI:3694287|PMID:16371367
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:Q9Z2D6MouseMGI:MGI:5528617|PMID:23770565
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:Q3TKT4MouseMGI:MGI:4819442|PMID:20596014
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:P97784|UniProtKB:Q8C4V4|UniProtKB:Q9WTL8MouseMGI:MGI:5882311|PMID:26776516
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:Q64104MouseMGI:MGI:6092585|PMID:17873065
Molecular FunctionGO:0005515protein bindingHdac3IPIUniProtKB:Q60793MousePMID:32467224
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:Q61909MousePMID:16227606
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:P97443MousePMID:11923873
Molecular FunctionGO:0005515protein bindingHdac3IPIUniPRotKB:Q5S006MousePMID:27798112
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:O88942MousePMID:19463978
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:O70374MousePMID:16227606
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:Q60974MousePMID:19037247
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:Q80ZK9MousePMID:17767906
Molecular FunctionGO:0005515protein bindingHdac3IPIPR:Q61645MousePMID:11641275
Molecular FunctionGO:0005515protein bindingHdac3IPIRGD:621567RatPMID:17079677|RGD:5688291
Molecular FunctionGO:0160010protein de-2-hydroxyisobutyrylase activityHDAC3IDAHumanPMID:29192674
Molecular FunctionGO:0160008protein decrotonylase activityHDAC3IDAHumanPMID:34608293
Molecular FunctionGO:0033558protein lysine deacetylase activityHDAC3IDAHumanPMID:17172643
Molecular FunctionGO:0033558protein lysine deacetylase activityHDAC3IDAHumanPMID:25301942
Molecular FunctionGO:0033558protein lysine deacetylase activityHdac3IDAMousePMID:24565863
Molecular FunctionGO:0033558protein lysine deacetylase activityHdac3IDAMousePMID:27798112
Molecular FunctionGO:0033558protein lysine deacetylase activityHdac3IDAMousePMID:17158926
Molecular FunctionGO:0003714transcription corepressor activityHDAC3IMPHumanPMID:12628926
Molecular FunctionGO:0003714transcription corepressor activityHDAC3IDAHumanPMID:16569215
Molecular FunctionGO:0003714transcription corepressor activityHDAC3IDAHumanPMID:18417529
Molecular FunctionGO:0001222transcription corepressor bindingHDAC3IPIUniProtKB:Q6W2J9HumanPMID:10898795
Molecular FunctionGO:0001222transcription corepressor bindingHDAC3IPIUniProtKB:Q96JN0HumanPMID:12535528
Molecular FunctionGO:0008134transcription factor bindingHdac3IDAMousePMID:17158926
Cellular ComponentGO:0000785chromatinHdac3IDARatPMID:17456789|RGD:2306459
Cellular ComponentGO:0005737cytoplasmHDAC3IDAHumanPMID:25190803
Cellular ComponentGO:0005737cytoplasmHdac3IDAMouseMGI:MGI:5882311|PMID:26776516
Cellular ComponentGO:0005737cytoplasmHdac3IDAMousePMID:17158926
Cellular ComponentGO:0005737cytoplasmHdac3IDAMousePMID:27798112
Cellular ComponentGO:0005737cytoplasmHdac3IDARatPMID:17456789|RGD:2306459
Cellular ComponentGO:0005829cytosolHDAC3IDAHumanPMID:21030595
Cellular ComponentGO:0005794Golgi apparatusHDAC3IDAHumanGO_REF:0000052
Cellular ComponentGO:0000118histone deacetylase complexHDAC3IDAHumanPMID:18326024
Cellular ComponentGO:0072686mitotic spindleHDAC3IDAHumanPMID:18326024
Cellular ComponentGO:0005654nucleoplasmHDAC3IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusHDAC3IDAHumanPMID:18326024
Cellular ComponentGO:0005634nucleusHDAC3IDAHumanPMID:18347167
Cellular ComponentGO:0005634nucleusHDAC3IDAHumanPMID:21030595
Cellular ComponentGO:0005634nucleusHdac3IDAMouseMGI:MGI:5882311|PMID:26776516
Cellular ComponentGO:0005634nucleusHdac3IPIUniProtKB:Q60793MousePMID:32467224
Cellular ComponentGO:0005634nucleusHdac3IDAMousePMID:17158926
Cellular ComponentGO:0005634nucleusHdac3IDAMousePMID:22297488
Cellular ComponentGO:0005634nucleusHdac3IDAMousePMID:27798112
Cellular ComponentGO:0005634nucleusHdac3IDARatPMID:17456789|RGD:2306459
Cellular ComponentGO:0005886plasma membraneHDAC3IDAHumanGO_REF:0000052
Cellular ComponentGO:0017053transcription repressor complexHDAC3IDAHumanPMID:11804585
Cellular ComponentGO:0017053transcription repressor complexHDAC3IDAHumanPMID:12628926
Cellular ComponentGO:0017053transcription repressor complexHDAC3IDAHumanPMID:16569215
Cellular ComponentGO:0017053transcription repressor complexHDAC3IDAHumanPMID:18417529
Biological ProcessGO:0001525angiogenesishdac3IMPZFIN:ZDB-MRPHLNO-080825-1ZfishPMID:18367159
Biological ProcessGO:0071498cellular response to fluid shear stressHDAC3IDAHumanPMID:25190803
Biological ProcessGO:0071260cellular response to mechanical stimulusHdac3IEPRatPMID:19261284|RGD:9590196
Biological ProcessGO:0071374cellular response to parathyroid hormone stimulusHdac3IEPRatPMID:20097749|RGD:9681006
Biological ProcessGO:0032922circadian regulation of gene expressionHdac3IMPMouseMGI:MGI:5882311|PMID:26776516
Biological ProcessGO:0032922circadian regulation of gene expressionHdac3IGIMGI:MGI:1349717MousePMID:19037247
Biological ProcessGO:1903575cornified envelope assemblyHdac3IMPMGI:MGI:4889069MousePMID:32467224
Biological ProcessGO:0009953dorsal/ventral pattern formationhdac3IGIZFIN:ZDB-MRPHLNO-080825-1,ZFIN:ZDB-MRPHLNO-120606-3ZfishPMID:22595677
Biological ProcessGO:0008544epidermis developmentHdac3IMPMGI:MGI:4889069MousePMID:32467224
Biological ProcessGO:0000132establishment of mitotic spindle orientationHDAC3IDAHumanPMID:34608293
Biological ProcessGO:0061436establishment of skin barrierHdac3IMPMGI:MGI:4889069MousePMID:32467224
Biological ProcessGO:0010467gene expressionHdac3IMPMGI:MGI:4889069MousePMID:32467224
Biological ProcessGO:0070932histone H3 deacetylationHdac3IEPRatPMID:17079677|RGD:5688291
Biological ProcessGO:0001701in utero embryonic developmentHdac3IMPMGI:MGI:4889069MousePMID:32467224
Biological ProcessGO:0001889liver developmenthdac3IMPZFIN:ZDB-MRPHLNO-080825-1ZfishPMID:18367159
Biological ProcessGO:2000726negative regulation of cardiac muscle cell differentiationHdac3IMPMousePMID:24565863
Biological ProcessGO:0043433negative regulation of DNA-binding transcription factor activityHdac3IDAMousePMID:24565863
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionHDAC3IMPHumanPMID:16924111
Biological ProcessGO:0032692negative regulation of interleukin-1 productionHdac3IMPRatPMID:22772764|RGD:9590127
Biological ProcessGO:0046329negative regulation of JNK cascadeHDAC3IMPHumanPMID:11931768
Biological ProcessGO:0046826negative regulation of protein export from nucleusHdac3IMPRatPMID:21695276|RGD:7247725
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHDAC3IMPHumanPMID:12628926
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHDAC3IDAHumanPMID:16569215
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHDAC3IDAHumanPMID:18417529
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHDAC3IDAHumanPMID:18854353
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHdac3IGIMGI:MGI:102541MousePMID:24565863
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHdac3IGIMGI:MGI:99533MousePMID:17158926
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHdac3IGIMGI:MGI:102469MousePMID:19463978
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionHdac3IMPRatPMID:22772764|RGD:9590127
Biological ProcessGO:0120162positive regulation of cold-induced thermogenesisHdac3IMPMouseMGI:MGI:6094824|PMID:28614293
Biological ProcessGO:0043525positive regulation of neuron apoptotic processHdac3IMPRatPMID:21289184|RGD:9590182
Biological ProcessGO:0042307positive regulation of protein import into nucleusHDAC3IDAHumanPMID:25190803
Biological ProcessGO:0001934positive regulation of protein phosphorylationHDAC3IDAHumanPMID:25190803
Biological ProcessGO:0031398positive regulation of protein ubiquitinationHdac3IMPMouseMGI:MGI:5882311|PMID:26776516
Biological ProcessGO:0032008positive regulation of TOR signalingHDAC3IMPHumanPMID:25190803
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHDAC3IDAHumanPMID:25190803
Biological ProcessGO:2000676positive regulation of type B pancreatic cell apoptotic processHdac3IMPRatPMID:22772764|RGD:9590127
Biological ProcessGO:0048916posterior lateral line developmenthdac3IMPZFIN:ZDB-MRPHLNO-080825-1ZfishPMID:26395281
Biological ProcessGO:0006476protein deacetylationHDAC3IDAHumanPMID:21030595
Biological ProcessGO:0006476protein deacetylationHDAC3IDAHumanPMID:25301942
Biological ProcessGO:0042752regulation of circadian rhythmHdac3IMPMouseMGI:MGI:5882311|PMID:26776516
Biological ProcessGO:0007346regulation of mitotic cell cycleHdac3IDAMousePMID:10542131
Biological ProcessGO:0040014regulation of multicellular organism growthHdac3IGIMGI:MGI:1349717MousePMID:19037247
Biological ProcessGO:0031647regulation of protein stabilityHDAC3IDAHumanPMID:25190803
Biological ProcessGO:0071548response to dexamethasoneHdac3IEPRatPMID:20538901|RGD:7364733
Biological ProcessGO:0031667response to nutrient levelsHdac3IEPRatPMID:21763752|RGD:9590183
Biological ProcessGO:0009410response to xenobiotic stimulusHdac3IEPRatPMID:18550052|RGD:2306220
Biological ProcessGO:0051225spindle assemblyHDAC3IMPHumanPMID:18326024
Biological ProcessGO:0006366transcription by RNA polymerase IIHdac3IGIMGI:MGI:102469MousePMID:19463978
Biological ProcessGO:0006366transcription by RNA polymerase IIHdac3IGIMGI:MGI:102541MousePMID:24565863

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory