Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HDAC5
  • Mouse genes Hdac5
  • Rat genes Hdac5
  • Zfish genes hdac5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hdac5	IDA		Rat	PMID:19638401|RGD:9590153
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HDAC5	IPI	UniProtKB:Q61686	Human	PMID:12242305
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Hdac5	IPI	UniProtKB:Q02078	Mouse	MGI:MGI:5009201|PMID:10748098
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hdac5	IMP		Mouse	MGI:MGI:4440396|PMID:20181743
Molecular Function	GO:0004407	histone deacetylase activity	HDAC5	IDA		Human	PMID:10869435
Molecular Function	GO:0042826	histone deacetylase binding	HDAC5	IPI	UniProtKB:O15379	Human	PMID:23867755
Molecular Function	GO:0042802	identical protein binding	HDAC5	IPI	UniProtKB:Q9UQL6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:O15379	Human	PMID:10869435
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P31946	Human	PMID:10869435
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P62258	Human	PMID:10869435
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P08393	Human	PMID:15194749
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P31947	Human	PMID:15923258
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q9HCU9	Human	PMID:16919237
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P23771	Human	PMID:17075044
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P35638	Human	PMID:17872950
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q8VEB1	Human	PMID:18711143
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q8TBE0	Human	PMID:19666599
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q06413	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P56524,UniProtKB:Q9H9E1	Human	PMID:22649097
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P31947	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P63104	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q06413	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q13761	Human	PMID:24229708
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q09472	Human	PMID:24413532
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q9H9E1	Human	PMID:25752541
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:P25791-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HDAC5	IPI	UniProtKB:Q9H9E1	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	UniProtKB:Q64321	Mouse	MGI:MGI:5446998|PMID:22730529
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	UniProtKB:P23242	Mouse	MGI:MGI:4939823|PMID:21282606
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	UniProtKB:Q64104	Mouse	MGI:MGI:6092585|PMID:17873065
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	UniProtKB:O35129	Mouse	MGI:MGI:3688342|PMID:15140878
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q8BUN5	Mouse	PMID:15990875
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q9WU42	Mouse	PMID:10640276
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q8VIM5	Mouse	PMID:15601857
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q08775	Mouse	PMID:15990875
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q6NZM9	Mouse	PMID:18332106
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:Q61645	Mouse	PMID:11641275
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	PR:O54946	Mouse	PMID:16260608
Molecular Function	GO:0005515	protein binding	Hdac5	IPI	RGD:621489	Rat	PMID:12896970|RGD:1304416
Molecular Function	GO:0019901	protein kinase binding	Hdac5	IPI	UniProtKB:Q60670	Mouse	MGI:MGI:3712602|PMID:17468767
Molecular Function	GO:0005080	protein kinase C binding	HDAC5	IPI	UniProtKB:Q16512	Human	PMID:20188095
Molecular Function	GO:0033558	protein lysine deacetylase activity	HDAC5	IMP		Human	PMID:23867755
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HDAC5	IDA		Human	PMID:24413532
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hdac5	IDA		Mouse	MGI:MGI:4440396|PMID:20181743
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC5	IPI	UniProtKB:Q61221	Human	PMID:19071119
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC5	IPI	UniProtKB:O35426-2	Human	PMID:20408817
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC5	IPI	UniProtKB:Q9NP62	Human	PMID:23867755
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hdac5	IPI	UniProtKB:Q64104	Mouse	MGI:MGI:4461095|PMID:20123967
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HDAC5	IDA		Human	PMID:19351956
Molecular Function	GO:0003714	transcription corepressor activity	Hdac5	IDA		Mouse	PMID:10640276
Molecular Function	GO:0003714	transcription corepressor activity	Hdac5	IGI	MGI:MGI:1201674	Mouse	PMID:15990875
Molecular Function	GO:0001222	transcription corepressor binding	HDAC5	IPI	UniProtKB:Q6W2J9	Human	PMID:10898795
Molecular Function	GO:0001222	transcription corepressor binding	Hdac5	IPI	UniProtKB:Q9JJY4	Mouse	MGI:MGI:2178490|PMID:12007404
Cellular Component	GO:0044295	axonal growth cone	Hdac5	IDA		Mouse	MGI:MGI:6378072|PMID:26157139
Cellular Component	GO:0000785	chromatin	Hdac5	IDA		Mouse	MGI:MGI:2178490|PMID:12007404
Cellular Component	GO:0005737	cytoplasm	HDAC5	IDA		Human	PMID:10869435
Cellular Component	GO:0005737	cytoplasm	HDAC5	IDA		Human	PMID:11081517
Cellular Component	GO:0005737	cytoplasm	HDAC5	IDA		Human	PMID:26157139
Cellular Component	GO:0005737	cytoplasm	Hdac5	IDA		Mouse	MGI:MGI:3712602|PMID:17468767
Cellular Component	GO:0005737	cytoplasm	Hdac5	IDA		Mouse	PMID:11081517
Cellular Component	GO:0005737	cytoplasm	Hdac5	IDA		Rat	PMID:12896970|RGD:1304416
Cellular Component	GO:0005737	cytoplasm	Hdac5	IDA		Rat	PMID:16767219|RGD:2306455
Cellular Component	GO:0005829	cytosol	HDAC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Hdac5	IDA		Mouse	PMID:18332106
Cellular Component	GO:0005829	cytosol	Hdac5	IDA		Mouse	PMID:18198354
Cellular Component	GO:0005794	Golgi apparatus	HDAC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	Hdac5	IDA		Mouse	PMID:11641275
Cellular Component	GO:0016607	nuclear speck	HDAC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HDAC5	IDA		Human	PMID:10869435
Cellular Component	GO:0005634	nucleus	HDAC5	IDA		Human	PMID:11081517
Cellular Component	GO:0005634	nucleus	HDAC5	IDA		Human	PMID:23867755
Cellular Component	GO:0005634	nucleus	HDAC5	IDA		Human	PMID:26157139
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Mouse	MGI:MGI:3712602|PMID:17468767
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Mouse	MGI:MGI:4440396|PMID:20181743
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Mouse	PMID:18198354
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Mouse	PMID:11081517
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Rat	PMID:12896970|RGD:1304416
Cellular Component	GO:0005634	nucleus	Hdac5	IDA		Rat	PMID:16767219|RGD:2306455
Cellular Component	GO:0032991	protein-containing complex	Hdac5	IDA		Rat	PMID:22360269|RGD:7241148
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	Hdac5	IDA		Mouse	MGI:MGI:2178490|PMID:12007404
Biological Process	GO:0071498	cellular response to fluid shear stress	Hdac5	IDA		Mouse	MGI:MGI:4440396|PMID:20181743
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Hdac5	IEP		Rat	PMID:22933299|RGD:9590257
Biological Process	GO:0040029	epigenetic regulation of gene expression	HDAC5	IMP		Human	PMID:24413532
Biological Process	GO:0007507	heart development	Hdac5	IGI	MGI:MGI:1931221	Mouse	PMID:15367668
Biological Process	GO:0016575	histone deacetylation	HDAC5	IDA		Human	PMID:10869435
Biological Process	GO:0033555	multicellular organismal response to stress	Hdac5	IMP	MGI:MGI:3056065	Mouse	PMID:17988634
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	HDAC5	IMP		Human	PMID:19351956
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hdac5	IDA		Mouse	PMID:16260608
Biological Process	GO:0010629	negative regulation of gene expression	Hdac5	IMP		Mouse	PMID:23926128
Biological Process	GO:0010832	negative regulation of myotube differentiation	HDAC5	IMP		Human	PMID:10983972
Biological Process	GO:0010832	negative regulation of myotube differentiation	HDAC5	IMP		Human	PMID:11081517
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Hdac5	IMP		Mouse	PMID:15990875
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC5	IDA		Human	PMID:16236793
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC5	IMP		Human	PMID:10983972
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC5	IMP		Human	PMID:19351956
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC5	IMP		Human	PMID:23867755
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IMP		Mouse	MGI:MGI:4440396|PMID:20181743
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IGI	MGI:MGI:2137495	Mouse	PMID:17940050
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IGI	MGI:MGI:98725	Mouse	PMID:15990875
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IDA		Mouse	PMID:23926128
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IGI	MGI:MGI:2137495	Mouse	PMID:15601857
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IDA		Mouse	PMID:10640276
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac5	IGI	MGI:MGI:97275	Mouse	PMID:17940050
Biological Process	GO:0030182	neuron differentiation	Hdac5	IEP		Rat	PMID:12850547|RGD:704464
Biological Process	GO:0002076	osteoblast development	Hdac5	IMP		Mouse	PMID:15990875
Biological Process	GO:0001649	osteoblast differentiation	Hdac5	IMP		Mouse	PMID:15990875
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	HDAC5	IMP		Human	PMID:19071119
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Hdac5	IMP		Mouse	MGI:MGI:4461095|PMID:20123967
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Hdac5	IMP		Mouse	MGI:MGI:4461095|PMID:20123967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HDAC5	IMP		Human	PMID:19071119
Biological Process	GO:0072114	pronephros morphogenesis	hdac5	IMP	ZFIN:ZDB-MRPHLNO-180926-7	Zfish	PMID:29633426
Biological Process	GO:0006476	protein deacetylation	HDAC5	IMP		Human	PMID:23867755
Biological Process	GO:0010830	regulation of myotube differentiation	Hdac5	IDA		Mouse	MGI:MGI:3712602|PMID:17468767
Biological Process	GO:0043393	regulation of protein binding	HDAC5	IMP		Human	PMID:19071119
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	Hdac5	IGI	MGI:MGI:3036234	Mouse	PMID:17786239
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	Hdac5	IGI	MGI:MGI:1931221	Mouse	PMID:17786239
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	Hdac5	IGI	MGI:MGI:3036234	Mouse	PMID:17786239
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	Hdac5	IGI	MGI:MGI:1931221	Mouse	PMID:17786239
Biological Process	GO:0061333	renal tubule morphogenesis	Hdac5	IMP		Mouse	MGI:MGI:4440396|PMID:20181743
Biological Process	GO:0014823	response to activity	Hdac5	IEP		Rat	PMID:21198979|RGD:9681460
Biological Process	GO:0042220	response to cocaine	Hdac5	IDA		Mouse	PMID:17988634
Biological Process	GO:0042220	response to cocaine	Hdac5	IMP	MGI:MGI:3056065	Mouse	PMID:17988634
Biological Process	GO:0042220	response to cocaine	Hdac5	IEP		Rat	PMID:21954104|RGD:9681462
Biological Process	GO:0009410	response to xenobiotic stimulus	Hdac5	IDA		Rat	PMID:16767219|RGD:2306455

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern