Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HDAC8
  • Mouse genes Hdac8
  • Rat genes Hdac8
  • Zfish genes hdac8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hdac8	IDA		Rat	PMID:28559304|RGD:13208603
Molecular Function	GO:0019213	deacetylase activity	Hdac8	IDA		Rat	PMID:23868068|RGD:9681716
Molecular Function	GO:0004407	histone deacetylase activity	HDAC8	IDA		Human	PMID:28497810
Molecular Function	GO:0160009	histone decrotonylase activity	HDAC8	IDA		Human	PMID:28497810
Molecular Function	GO:0030544	Hsp70 protein binding	HDAC8	IPI	UniProtKB:P0DMV8	Human	PMID:16809764
Molecular Function	GO:0030544	Hsp70 protein binding	HDAC8	IPI	UniProtKB:P0DMV9	Human	PMID:16809764
Molecular Function	GO:0051879	Hsp90 protein binding	HDAC8	IPI	UniProtKB:P07900	Human	PMID:16809764
Molecular Function	GO:0051879	Hsp90 protein binding	HDAC8	IPI	UniProtKB:P08238	Human	PMID:16809764
Molecular Function	GO:0005515	protein binding	HDAC8	IPI	UniProtKB:Q9UPR3	Human	PMID:16809764
Molecular Function	GO:0005515	protein binding	HDAC8	IPI	UniProtKB:P43246	Human	PMID:26221039
Molecular Function	GO:0033558	protein lysine deacetylase activity	HDAC8	IDA		Human	PMID:22885700
Cellular Component	GO:0005634	nucleus	Hdac8	IDA		Rat	PMID:28559304|RGD:13208603
Biological Process	GO:1904322	cellular response to forskolin	Hdac8	IDA		Rat	PMID:28559304|RGD:13208603
Biological Process	GO:0035984	cellular response to trichostatin A	Hdac8	IDA		Rat	PMID:26391271|RGD:11344521
Biological Process	GO:0007417	central nervous system development	hdac8	IMP	ZFIN:ZDB-MRPHLNO-200304-3	Zfish	PMID:30239720
Biological Process	GO:0007417	central nervous system development	hdac8	IMP	ZFIN:ZDB-MRPHLNO-200304-2	Zfish	PMID:30239720
Biological Process	GO:0007064	mitotic sister chromatid cohesion	HDAC8	IMP		Human	PMID:22885700
Biological Process	GO:0010629	negative regulation of gene expression	Hdac8	IMP		Rat	PMID:28559304|RGD:13208603
Biological Process	GO:2000616	negative regulation of histone H3-K9 acetylation	Hdac8	IMP		Rat	PMID:25019367|RGD:13208813
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Hdac8	IMP		Rat	PMID:25019367|RGD:13208813
Biological Process	GO:0031397	negative regulation of protein ubiquitination	HDAC8	IDA		Human	PMID:16809764
Biological Process	GO:0070050	neuron cellular homeostasis	hdac8	IMP	ZFIN:ZDB-MRPHLNO-200304-3	Zfish	PMID:30239720
Biological Process	GO:0070050	neuron cellular homeostasis	hdac8	IMP	ZFIN:ZDB-MRPHLNO-200304-2	Zfish	PMID:30239720
Biological Process	GO:0031647	regulation of protein stability	HDAC8	IDA		Human	PMID:16809764
Biological Process	GO:0032204	regulation of telomere maintenance	HDAC8	IMP		Human	PMID:16809764
Biological Process	GO:1903496	response to 11-deoxycorticosterone	Hdac8	IDA		Rat	PMID:23868068|RGD:9681716

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern