Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HDAC9
  • Mouse genes Hdac9
  • Rat genes Hdac9
  • Zfish genes hdac9b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hdac9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HDAC9	IPI	UniProtKB:Q02078	Human	PMID:10748098
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HDAC9	IDA		Human	PMID:12590135
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HDAC9	IPI	UniProtKB:Q9BZS1	Human	PMID:17360565
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Hdac9	IPI	UniProtKB:Q61686	Mouse	MGI:MGI:4359370|PMID:12242305
Molecular Function	GO:0004407	histone deacetylase activity	HDAC9	IDA		Human	PMID:11535832
Molecular Function	GO:0042826	histone deacetylase binding	HDAC9	IPI	UniProtKB:O15379	Human	PMID:12590135
Molecular Function	GO:0042826	histone deacetylase binding	HDAC9	IPI	UniProtKB:P56524	Human	PMID:12590135
Molecular Function	GO:0042826	histone deacetylase binding	HDAC9	IPI	UniProtKB:Q13547	Human	PMID:12590135
Molecular Function	GO:0031078	histone H3K14 deacetylase activity	Hdac9	IMP		Mouse	MGI:MGI:5287924|PMID:21708950
Molecular Function	GO:0032129	histone H3K9 deacetylase activity	Hdac9	IMP		Mouse	MGI:MGI:5287924|PMID:21708950
Molecular Function	GO:0034739	histone H4K16 deacetylase activity	HDAC9	IDA		Human	PMID:28855441
Molecular Function	GO:0005515	protein binding	HDAC9	IPI	UniProtKB:P41182	Human	PMID:12590135
Molecular Function	GO:0005515	protein binding	HDAC9	IPI	UniProtKB:P41182	Human	PMID:16147992
Molecular Function	GO:0005515	protein binding	HDAC9	IPI	UniProtKB:Q06413	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	HDAC9	IPI	UniProtKB:Q06413	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	HDAC9	IPI	UniProtKB:P43246	Human	PMID:26221039
Molecular Function	GO:0005515	protein binding	Hdac9	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:4819442|PMID:20596014
Molecular Function	GO:0005515	protein binding	Hdac9	IPI	UniProtKB:P60335	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Hdac9	IPI	UniProtKB:Q9Z2V5	Mouse	MGI:MGI:6368062|PMID:25873389
Molecular Function	GO:0005515	protein binding	Hdac9	IPI	PR:O88712	Mouse	PMID:11390982
Molecular Function	GO:0005080	protein kinase C binding	HDAC9	IPI	UniProtKB:Q16512	Human	PMID:20188095
Molecular Function	GO:0033558	protein lysine deacetylase activity	HDAC9	IDA		Human	PMID:11535832
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC9	IDA		Human	PMID:11535832
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC9	IPI	UniProtKB:Q02080	Human	PMID:15567413
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HDAC9	IPI	UniProtKB:P22415	Human	PMID:19303849
Molecular Function	GO:0003714	transcription corepressor activity	Hdac9	IDA		Mouse	PMID:11022042
Cellular Component	GO:0005737	cytoplasm	HDAC9	IDA		Human	PMID:12590135
Cellular Component	GO:0005737	cytoplasm	HDAC9	IDA		Human	PMID:20188095
Cellular Component	GO:0035097	histone methyltransferase complex	Hdac9	IDA		Mouse	MGI:MGI:4359370|PMID:12242305
Cellular Component	GO:0005634	nucleus	HDAC9	IDA		Human	PMID:12590135
Cellular Component	GO:0005634	nucleus	HDAC9	IDA		Human	PMID:20188095
Cellular Component	GO:0005634	nucleus	Hdac9	IDA		Rat	PMID:18632988|RGD:9588273
Cellular Component	GO:0005667	transcription regulator complex	HDAC9	IDA		Human	PMID:15567413
Cellular Component	GO:0005667	transcription regulator complex	HDAC9	IDA		Human	PMID:19303849
Biological Process	GO:0001525	angiogenesis	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-1	Zfish	PMID:23288173
Biological Process	GO:0001525	angiogenesis	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-2	Zfish	PMID:23288173
Biological Process	GO:0032869	cellular response to insulin stimulus	HDAC9	IDA		Human	PMID:19303849
Biological Process	GO:0042632	cholesterol homeostasis	HDAC9	IDA		Human	PMID:28855441
Biological Process	GO:0008340	determination of adult lifespan	Hdac9	IGI	MGI:MGI:1890508	Mouse	PMID:21746928
Biological Process	GO:0006281	DNA repair	Hdac9	IGI	MGI:MGI:1890508	Mouse	PMID:21746928
Biological Process	GO:0007507	heart development	Hdac9	IGI	MGI:MGI:1333784	Mouse	PMID:15367668
Biological Process	GO:0001945	lymph vessel development	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-1	Zfish	PMID:23288173
Biological Process	GO:0001945	lymph vessel development	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-2	Zfish	PMID:23288173
Biological Process	GO:0001818	negative regulation of cytokine production	HDAC9	IDA		Human	PMID:28855441
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HDAC9	IDA		Human	PMID:11535832
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hdac9	IDA		Mouse	PMID:11022042
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hdac9	IDA		Mouse	PMID:16260608
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	HDAC9	IDA		Human	PMID:11535832
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	HDAC9	IDA		Human	PMID:12590135
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	HDAC9	IDA		Human	PMID:28855441
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Hdac9	IMP		Mouse	MGI:MGI:5287924|PMID:21708950
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	HDAC9	IDA		Human	PMID:28855441
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC9	IDA		Human	PMID:10655483
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HDAC9	IDA		Human	PMID:11535832
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac9	IMP		Mouse	PMID:16280321
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hdac9	IDA		Mouse	PMID:11390982
Biological Process	GO:0030182	neuron differentiation	Hdac9	IEP		Rat	PMID:12850547|RGD:704464
Biological Process	GO:0034983	peptidyl-lysine deacetylation	HDAC9	IDA		Human	PMID:11535832
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	HDAC9	IMP		Human	PMID:19351956
Biological Process	GO:0060319	primitive erythrocyte differentiation	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-141119-26	Zfish	PMID:24240475
Biological Process	GO:0060215	primitive hemopoiesis	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-141119-26	Zfish	PMID:24240475
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	Hdac9	IGI	MGI:MGI:1333784	Mouse	PMID:17786239
Biological Process	GO:0048742	regulation of skeletal muscle fiber development	Hdac9	IGI	MGI:MGI:3036284	Mouse	PMID:17786239
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	Hdac9	IGI	MGI:MGI:3036284	Mouse	PMID:17786239
Biological Process	GO:1902809	regulation of skeletal muscle fiber differentiation	Hdac9	IGI	MGI:MGI:1333784	Mouse	PMID:17786239
Biological Process	GO:0001975	response to amphetamine	Hdac9	IEP		Rat	PMID:25452209|RGD:9681719
Biological Process	GO:0001944	vasculature development	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-2	Zfish	PMID:23288173
Biological Process	GO:0001944	vasculature development	hdac9b	IMP	ZFIN:ZDB-MRPHLNO-150724-1	Zfish	PMID:23288173

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern