Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HELLS
  • Mouse genes Hells
  • Rat genes Hells
  • Zfish genes hells
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hells

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hells	IDA		Mouse	PMID:15448183
Molecular Function	GO:0005515	protein binding	HELLS	IPI	UniProtKB:O00716	Human	PMID:22157815
Molecular Function	GO:0005515	protein binding	Hells	IPI	UniProtKB:P23798|UniProtKB:P25916|UniProtKB:P30658	Mouse	MGI:MGI:6092708|PMID:17726103
Molecular Function	GO:0005515	protein binding	Hells	IPI	UniProtKB:O88508|UniProtKB:O88509	Mouse	MGI:MGI:5508259|PMID:16395332
Cellular Component	GO:0000775	chromosome, centromeric region	Hells	IDA		Mouse	MGI:MGI:3041983|PMID:14612388
Cellular Component	GO:0005634	nucleus	Hells	IDA		Mouse	PMID:11555636
Cellular Component	GO:0005721	pericentric heterochromatin	Hells	IDA		Mouse	MGI:MGI:3041983|PMID:14612388
Biological Process	GO:0006915	apoptotic process	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:11325543
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Hells	IEP		Mouse	PMID:20439489
Biological Process	GO:0006306	DNA methylation	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:11711429
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Hells	IMP		Mouse	MGI:MGI:3573964|PMID:15647320
Biological Process	GO:0031507	heterochromatin formation	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:15448183
Biological Process	GO:0001822	kidney development	Hells	IMP		Mouse	MGI:MGI:2178571|PMID:11325543
Biological Process	GO:0046651	lymphocyte proliferation	Hells	IEP		Mouse	MGI:MGI:1855809|PMID:10781083
Biological Process	GO:0043066	negative regulation of apoptotic process	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:11325543
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Hells	IMP		Mouse	MGI:MGI:3620346|PMID:15105378
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:11325543
Biological Process	GO:0031508	pericentric heterochromatin formation	Hells	IMP		Mouse	MGI:MGI:3041983|PMID:14612388
Biological Process	GO:0044030	regulation of DNA methylation	hells	IMP	ZFIN:ZDB-MRPHLNO-170428-2	Zfish	PMID:26491684
Biological Process	GO:0001655	urogenital system development	Hells	IMP	MGI:MGI:2178586	Mouse	PMID:11325543

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern