Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HERPUD1
  • Mouse genes Herpud1
  • Rat genes Herpud1
  • Zfish genes herpud1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Herpud1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HERPUD1	IPI	UniProtKB:Q9NRR5	Human	PMID:18307982
Molecular Function	GO:0005515	protein binding	HERPUD1	IPI	UniProtKB:Q9UHD9	Human	PMID:18307982
Molecular Function	GO:0005515	protein binding	HERPUD1	IPI	UniProtKB:Q9UMX0	Human	PMID:18307982
Molecular Function	GO:0005515	protein binding	HERPUD1	IPI	UniProtKB:Q86TM6	Human	PMID:28827405
Molecular Function	GO:0005515	protein binding	Herpud1	IPI	PR:P57716	Mouse	PMID:21600962
Molecular Function	GO:0044325	transmembrane transporter binding	HERPUD1	IPI	UniProtKB:Q14643	Human	PMID:22045699
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	Herpud1	IMP		Mouse	PMID:21600962
Cellular Component	GO:0005783	endoplasmic reticulum	HERPUD1	IDA		Human	PMID:15102845
Cellular Component	GO:0005783	endoplasmic reticulum	HERPUD1	IDA		Human	PMID:19788048
Cellular Component	GO:0005783	endoplasmic reticulum	HERPUD1	IDA		Human	PMID:22045699
Cellular Component	GO:0005783	endoplasmic reticulum	Herpud1	IDA		Mouse	MGI:MGI:5613477|PMID:15147274
Cellular Component	GO:0005789	endoplasmic reticulum membrane	HERPUD1	IDA		Human	PMID:10922362
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Herpud1	IDA		Mouse	PMID:10922362
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	Herpud1	IDA		Mouse	MGI:MGI:6467687|PMID:24478453
Cellular Component	GO:1990037	Lewy body core	HERPUD1	IDA		Human	PMID:19788048
Cellular Component	GO:0016020	membrane	HERPUD1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Herpud1	IDA		Mouse	PMID:10922362
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	HERPUD1	IDA		Human	PMID:15102845
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	HERPUD1	IDA		Human	PMID:22045699
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Herpud1	IDA		Mouse	PMID:10922362
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Herpud1	IMP		Rat	PMID:15102845|RGD:1304324
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Herpud1	IMP		Rat	PMID:15102845|RGD:1304324
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Herpud1	IMP		Rat	PMID:15102845|RGD:1304324
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	HERPUD1	IDA		Human	PMID:15102845
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	HERPUD1	IGI	UniProtKB:P37840	Human	PMID:22045699
Biological Process	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	HERPUD1	IMP		Human	PMID:18307982
Biological Process	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	HERPUD1	IDA		Human	PMID:22045699
Biological Process	GO:0045047	protein targeting to ER	Herpud1	IMP		Mouse	MGI:MGI:6467687|PMID:24478453
Biological Process	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Herpud1	IMP		Mouse	MGI:MGI:5613477|PMID:15147274
Biological Process	GO:1903069	regulation of ER-associated ubiquitin-dependent protein catabolic process	Herpud1	IMP		Mouse	MGI:MGI:5613477|PMID:15147274
Biological Process	GO:0031396	regulation of protein ubiquitination	Herpud1	IMP		Mouse	PMID:21600962
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Herpud1	IDA		Mouse	PMID:25637874
Biological Process	GO:0006986	response to unfolded protein	HERPUD1	IEP		Human	PMID:10708769
Biological Process	GO:0006986	response to unfolded protein	HERPUD1	IEP		Human	PMID:10922362
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	HERPUD1	IMP		Human	PMID:25660456
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	HERPUD1	IMP		Human	PMID:28827405
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Herpud1	IDA		Mouse	PMID:21600962
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Herpud1	IMP		Mouse	PMID:21600962

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern