Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HES5
  • Mouse genes Hes5
  • Rat genes Hes5
  • Zfish genes her12,her15.1,her15.2,her2,her4.1,her4.2,her4.3,her4.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hes5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hes5	IDA		Rat	PMID:17006542|RGD:8554845
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	her2	IDA		Zfish	PMID:26714454
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	her2	IDA		Zfish	PMID:25446033
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hes5	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0003690	double-stranded DNA binding	Hes5	IDA		Rat	PMID:1400497|RGD:728403
Molecular Function	GO:0003690	double-stranded DNA binding	her4.1	IDA		Zfish	PMID:15169758
Molecular Function	GO:0005515	protein binding	Hes5	IPI	UniProtKB:P42227|UniProtKB:Q62120	Mouse	MGI:MGI:5284803|PMID:15156153
Molecular Function	GO:0005515	protein binding	Hes5	IPI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HES5	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	her2	IDA		Zfish	PMID:26714454
Cellular Component	GO:0000785	chromatin	her2	IDA		Zfish	PMID:25446033
Biological Process	GO:0009952	anterior/posterior pattern specification	her4.1	IGI	ZFIN:ZDB-GENE-980526-144	Zfish	PMID:15023930
Biological Process	GO:0048708	astrocyte differentiation	Hes5	IDA		Mouse	MGI:MGI:5284803|PMID:15156153
Biological Process	GO:0030509	BMP signaling pathway	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:18579678
Biological Process	GO:0007420	brain development	Hes5	IMP		Mouse	MGI:MGI:3703278|PMID:17331197
Biological Process	GO:0007420	brain development	her15.1	IDA		Zfish	PMID:17274976
Biological Process	GO:0007420	brain development	her12	IMP		Zfish	PMID:17274976
Biological Process	GO:0043010	camera-type eye development	Hes5	IMP		Mouse	MGI:MGI:3703278|PMID:17331197
Biological Process	GO:0051216	cartilage development	HES5	IDA		Human	PMID:17093926
Biological Process	GO:0051216	cartilage development	Hes5	IMP		Mouse	MGI:MGI:5285816|PMID:17093926
Biological Process	GO:0007155	cell adhesion	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:15496443
Biological Process	GO:0001708	cell fate specification	her4.1	IMP	ZFIN:ZDB-MRPHLNO-100105-3	Zfish	PMID:27027936
Biological Process	GO:0048469	cell maturation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:15496443
Biological Process	GO:0022010	central nervous system myelination	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:0072049	comma-shaped body morphogenesis	Hes5	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0090162	establishment of epithelial cell polarity	Hes5	IGI	MGI:MGI:1341800	Mouse	PMID:21300049
Biological Process	GO:0090162	establishment of epithelial cell polarity	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0001654	eye development	her15.1	IDA		Zfish	PMID:17274976
Biological Process	GO:0021861	forebrain radial glial cell differentiation	Hes5	IDA		Rat	PMID:11399758|RGD:8554692
Biological Process	GO:0010001	glial cell differentiation	her2	IMP	ZFIN:ZDB-MRPHLNO-130503-1	Zfish	PMID:26714454
Biological Process	GO:0021781	glial cell fate commitment	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:10821751
Biological Process	GO:0042063	gliogenesis	her2	IMP	ZFIN:ZDB-MRPHLNO-150402-2	Zfish	PMID:25446033
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Hes5	IGI	MGI:MGI:1341800	Mouse	PMID:21300049
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Hes5	IGI	MGI:MGI:1341800	Mouse	PMID:21300049
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	Hes5	IEP		Mouse	MGI:MGI:3056024|PMID:15465493
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Hes5	IDA		Mouse	MGI:MGI:2655020|PMID:12666205
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hes5	IMP		Mouse	MGI:MGI:3625195|PMID:12208538
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hes5	IDA		Rat	PMID:1400497|RGD:728403
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	her2	IDA		Zfish	PMID:25446033
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	Hes5	IDA		Rat	PMID:11399758|RGD:8554692
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:11425898
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	Hes5	IGI	MGI:MGI:1341800	Mouse	PMID:21300049
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:2000981	negative regulation of inner ear receptor cell differentiation	Hes5	IMP		Mouse	MGI:MGI:3625195|PMID:12208538
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IGI	MGI:MGI:1920441	Mouse	PMID:20431123
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:10205173
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:15496443
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IGI	MGI:MGI:1859823	Mouse	PMID:20431123
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IGI	MGI:MGI:97363	Mouse	PMID:10205173
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:10205173
Biological Process	GO:0045665	negative regulation of neuron differentiation	her2	IMP	ZFIN:ZDB-MRPHLNO-150402-2	Zfish	PMID:25446033
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Hes5	IDA		Mouse	MGI:MGI:2655020|PMID:12666205
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation	Hes5	IMP		Rat	PMID:12032823|RGD:8553570
Biological Process	GO:2000737	negative regulation of stem cell differentiation	HES5	IMP		Human	PMID:19682396
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes5	IGI	MGI:MGI:104877	Mouse	PMID:19050759
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes5	IDA		Rat	PMID:17006542|RGD:8554845
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes5	IDA		Rat	PMID:12032823|RGD:8553570
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	her2	IDA		Zfish	PMID:26714454
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	her2	IMP		Zfish	PMID:26714454
Biological Process	GO:0021915	neural tube development	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:10804175
Biological Process	GO:0007405	neuroblast proliferation	her2	IMP	ZFIN:ZDB-MRPHLNO-150402-2	Zfish	PMID:25446033
Biological Process	GO:0030182	neuron differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:10205173
Biological Process	GO:0030182	neuron differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:10205173
Biological Process	GO:0030182	neuron differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:15496443
Biological Process	GO:0030182	neuron differentiation	Hes5	IGI	MGI:MGI:97363	Mouse	PMID:10205173
Biological Process	GO:0030182	neuron differentiation	Hes5	IGI	MGI:MGI:1859823	Mouse	PMID:20431123
Biological Process	GO:0030182	neuron differentiation	Hes5	IGI	MGI:MGI:1920441	Mouse	PMID:20431123
Biological Process	GO:0030182	neuron differentiation	Hes5	IEP		Rat	PMID:1400497|RGD:728403
Biological Process	GO:0030182	neuron differentiation	her2	IMP	ZFIN:ZDB-MRPHLNO-130503-1	Zfish	PMID:26714454
Biological Process	GO:0097150	neuronal stem cell population maintenance	HES5	IEP		Human	PMID:19682396
Biological Process	GO:0097150	neuronal stem cell population maintenance	Hes5	IMP		Mouse	MGI:MGI:5142379|PMID:11399758
Biological Process	GO:0097150	neuronal stem cell population maintenance	Hes5	IDA		Rat	PMID:11399758|RGD:8554692
Biological Process	GO:0007219	Notch signaling pathway	HES5	IMP		Human	PMID:19682396
Biological Process	GO:0007219	Notch signaling pathway	HES5	IMP		Human	PMID:19855400
Biological Process	GO:0007219	Notch signaling pathway	Hes5	IMP		Mouse	MGI:MGI:3703278|PMID:17331197
Biological Process	GO:0007219	Notch signaling pathway	Hes5	IDA		Mouse	PMID:25535395
Biological Process	GO:0007219	Notch signaling pathway	her15.1	IGI	ZFIN:ZDB-GENO-070123-3,ZFIN:ZDB-GENO-070123-4,ZFIN:ZDB-GENO-980202-1125	Zfish	PMID:17274976
Biological Process	GO:0007219	Notch signaling pathway	her12	IGI	ZFIN:ZDB-GENO-070123-3,ZFIN:ZDB-GENO-070123-4,ZFIN:ZDB-GENO-980202-1125	Zfish	PMID:17274976
Biological Process	GO:0007219	Notch signaling pathway	her4.1	IMP		Zfish	PMID:15023930
Biological Process	GO:0014003	oligodendrocyte development	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:0048709	oligodendrocyte differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	her4.2	IGI	ZFIN:ZDB-MRPHLNO-100105-4	Zfish	PMID:19084503
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	her4.3	IGI	ZFIN:ZDB-MRPHLNO-100105-4	Zfish	PMID:19084503
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	her4.4	IGI	ZFIN:ZDB-MRPHLNO-100105-4	Zfish	PMID:19084503
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	her4.1	IGI	ZFIN:ZDB-MRPHLNO-100105-4	Zfish	PMID:19084503
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:18579678
Biological Process	GO:0008284	positive regulation of cell population proliferation	HES5	IMP		Human	PMID:17849174
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hes5	IMP		Mouse	MGI:MGI:3625195|PMID:12208538
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Hes5	IMP		Mouse	MGI:MGI:3625195|PMID:12208538
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Hes5	IDA		Mouse	MGI:MGI:5284803|PMID:15156153
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	HES5	IGI	UniProtKB:Q61982	Human	PMID:19855400
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hes5	IGI	MGI:MGI:104877	Mouse	PMID:19050759
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Hes5	IDA		Mouse	MGI:MGI:5284803|PMID:15156153
Biological Process	GO:0065003	protein-containing complex assembly	Hes5	IDA		Mouse	MGI:MGI:5284803|PMID:15156153
Biological Process	GO:0045595	regulation of cell differentiation	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:18048645
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Hes5	IGI	MGI:MGI:1341800	Mouse	PMID:21300049
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:21300049
Biological Process	GO:0031641	regulation of myelination	Hes5	IMP	MGI:MGI:2149674	Mouse	PMID:17006542
Biological Process	GO:0050767	regulation of neurogenesis	Hes5	IGI	MGI:MGI:104877	Mouse	PMID:19050759
Biological Process	GO:0050767	regulation of neurogenesis	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:19050759
Biological Process	GO:0050767	regulation of neurogenesis	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:10804175
Biological Process	GO:0045664	regulation of neuron differentiation	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:10804175
Biological Process	GO:0045664	regulation of neuron differentiation	her2	IGI	ZFIN:ZDB-MRPHLNO-150925-1,ZFIN:ZDB-MRPHLNO-150925-2	Zfish	PMID:25948585
Biological Process	GO:0072050	S-shaped body morphogenesis	Hes5	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0007224	smoothened signaling pathway	Hes5	IDA		Mouse	PMID:19124651
Biological Process	GO:0001757	somite specification	her4.1	IMP		Zfish	PMID:15023930
Biological Process	GO:0001756	somitogenesis	her15.1	IDA		Zfish	PMID:17274976
Biological Process	GO:0001756	somitogenesis	her12	IMP	ZFIN:ZDB-MRPHLNO-070628-8	Zfish	PMID:17274976
Biological Process	GO:0072086	specification of loop of Henle identity	Hes5	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0021537	telencephalon development	Hes5	IGI	MGI:MGI:1920441	Mouse	PMID:20431123
Biological Process	GO:0021537	telencephalon development	Hes5	IGI	MGI:MGI:104853	Mouse	PMID:18579678
Biological Process	GO:0021537	telencephalon development	Hes5	IGI	MGI:MGI:1859823	Mouse	PMID:20431123

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern