Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HES7
  • Mouse genes Hes7
  • Rat genes Hes7
  • Zfish genes her1,her11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hes7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HES7	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HES7	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HES7	IPI	UniProtKB:Q8N8B7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HES7	IPI	UniProtKB:Q8WWB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HES7	IPI	UniProtKB:Q8WWY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	her11	IPI	UniProtKB:P79734	Zfish	PMID:15590746
Molecular Function	GO:0046982	protein heterodimerization activity	her11	IPI	UniProtKB:Q90467	Zfish	PMID:15590746
Molecular Function	GO:0046982	protein heterodimerization activity	her1	IPI	UniProtKB:Q6P0J1	Zfish	PMID:15905406
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Hes7	IDA		Mouse	MGI:MGI:3611993|PMID:16342160
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HES7	IDA		Human	PMID:28473536
Biological Process	GO:0030917	midbrain-hindbrain boundary development	her11	IMP		Zfish	PMID:18725518
Biological Process	GO:0030917	midbrain-hindbrain boundary development	her11	IMP		Zfish	PMID:15590746
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hes7	IDA		Mouse	MGI:MGI:4943377|PMID:18775957
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hes7	IDA		Mouse	PMID:12783854
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	her1	IPI	UniProtKB:Q90463	Zfish	PMID:15905406
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	her1	IDA		Zfish	PMID:15905406
Biological Process	GO:0050768	negative regulation of neurogenesis	her11	IMP		Zfish	PMID:15590746
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes7	IDA		Mouse	PMID:11260262
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes7	IGI	MGI:MGI:1860483	Mouse	PMID:21750544
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes7	IDA		Mouse	PMID:15170214
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hes7	IDA		Mouse	PMID:15902259
Biological Process	GO:0007219	Notch signaling pathway	Hes7	IDA		Mouse	PMID:11260262
Biological Process	GO:0036342	post-anal tail morphogenesis	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:11641270
Biological Process	GO:0048511	rhythmic process	Hes7	IMP	MGI:MGI:3046536	Mouse	PMID:15170214
Biological Process	GO:0048511	rhythmic process	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:15170214
Biological Process	GO:0048511	rhythmic process	Hes7	IDA		Mouse	PMID:11641270
Biological Process	GO:0001501	skeletal system development	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:11641270
Biological Process	GO:0001757	somite specification	her1	IMP	ZFIN:ZDB-GENO-120725-2	Zfish	PMID:22723933
Biological Process	GO:0001757	somite specification	her1	IGI	ZFIN:ZDB-GENO-120725-3	Zfish	PMID:22723933
Biological Process	GO:0001756	somitogenesis	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:15170214
Biological Process	GO:0001756	somitogenesis	Hes7	IMP	MGI:MGI:3046536	Mouse	PMID:15170214
Biological Process	GO:0001756	somitogenesis	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:19779553
Biological Process	GO:0001756	somitogenesis	Hes7	IMP	MGI:MGI:2652222	Mouse	PMID:11641270
Biological Process	GO:0001756	somitogenesis	her1	IGI	ZFIN:ZDB-GENO-120514-2,ZFIN:ZDB-MRPHLNO-050526-3,ZFIN:ZDB-MRPHLNO-060626-2	Zfish	PMID:20637625
Biological Process	GO:0001756	somitogenesis	her1	IGI	ZFIN:ZDB-GENO-200219-4	Zfish	PMID:29624170
Biological Process	GO:0001756	somitogenesis	her1	IMP	ZFIN:ZDB-GENO-120725-2	Zfish	PMID:29624170
Biological Process	GO:0001756	somitogenesis	her1	IMP	ZFIN:ZDB-MRPHLNO-060626-1	Zfish	PMID:16545363
Biological Process	GO:0001756	somitogenesis	her1	IGI	ZFIN:ZDB-MRPHLNO-060626-1,ZFIN:ZDB-MRPHLNO-060626-7	Zfish	PMID:16545363
Biological Process	GO:0001756	somitogenesis	her1	IMP	ZFIN:ZDB-GENO-071120-1	Zfish	PMID:17535112
Biological Process	GO:0001756	somitogenesis	her1	IGI	ZFIN:ZDB-GENE-000427-6	Zfish	PMID:12117818
Biological Process	GO:0001756	somitogenesis	her1	IEP		Zfish	PMID:16760970
Biological Process	GO:0001756	somitogenesis	her1	IGI	ZFIN:ZDB-GENO-200219-5	Zfish	PMID:29624170

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern