Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HESX1
  • Mouse genes Hesx1
  • Rat genes Hesx1
  • Zfish genes hesx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hesx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hesx1	IDA		Mouse	PMID:16678101
Molecular Function	GO:0003677	DNA binding	HESX1	IDA		Human	PMID:26781211
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	HESX1	IDA		Human	PMID:11748154
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hesx1	IDA		Mouse	MGI:MGI:5825430|PMID:17445765
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:O60341	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:Q96LA8	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:Q7Z7H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:Q96NT3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:Q9BZL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HESX1	IPI	UniProtKB:Q9NX04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	UniProtKB:Q9GLL9	Mouse	PMID:19879326
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	UniProtKB:P13864	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:P13864	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:Q9DBN5	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:Q8BHZ4	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:Q6P1E1	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	MGI:MGI:1933831	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:D3YXK2	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Hesx1	IPI	PR:Q9CZ91	Mouse	PMID:17931718
Molecular Function	GO:0042803	protein homodimerization activity	Hesx1	IDA		Mouse	PMID:12063185
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HESX1	IMP		Human	PMID:11748154
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HESX1	IDA		Human	PMID:26781211
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hesx1	IDA		Mouse	MGI:MGI:5825430|PMID:17445765
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HESX1	IDA		Human	PMID:11748154
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Hesx1	IDA		Mouse	PMID:17445765
Molecular Function	GO:0043565	sequence-specific DNA binding	Hesx1	IDA		Mouse	PMID:12063185
Molecular Function	GO:0043565	sequence-specific DNA binding	Hesx1	IDA		Mouse	PMID:19879326
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HESX1	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Hesx1	IMP		Mouse	PMID:11748154
Cellular Component	GO:0005634	nucleus	HESX1	IDA		Human	PMID:26781211
Cellular Component	GO:0005634	nucleus	Hesx1	IDA		Mouse	PMID:17931718
Biological Process	GO:0007420	brain development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:11291863
Biological Process	GO:0043010	camera-type eye development	Hesx1	IMP	MGI:MGI:3822474	Mouse	PMID:19093031
Biological Process	GO:0060070	canonical Wnt signaling pathway	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:17360769
Biological Process	GO:0071276	cellular response to cadmium ion	Hesx1	IDA		Mouse	PMID:15219627
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Hesx1	IMP		Mouse	PMID:31761678
Biological Process	GO:0030900	forebrain development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:17360769
Biological Process	GO:0030900	forebrain development	Hesx1	IDA		Mouse	PMID:24520934
Biological Process	GO:0030900	forebrain development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:9620767
Biological Process	GO:0030900	forebrain development	hesx1	IGI	ZFIN:ZDB-GENO-080909-1,ZFIN:ZDB-MRPHLNO-111104-1	Zfish	PMID:22007134
Biological Process	GO:0048853	forebrain morphogenesis	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:10882526
Biological Process	GO:0048853	forebrain morphogenesis	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:9620767
Biological Process	GO:0010467	gene expression	Hesx1	IDA		Mouse	PMID:12063185
Biological Process	GO:0010467	gene expression	Hesx1	IDA		Mouse	PMID:26188092
Biological Process	GO:0010467	gene expression	Hesx1	IDA		Mouse	PMID:17445765
Biological Process	GO:0008406	gonad development	Hesx1	IGI	MGI:MGI:102764	Mouse	PMID:18775421
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	Hesx1	IMP		Mouse	PMID:31761678
Biological Process	GO:0035264	multicellular organism growth	Hesx1	IGI	MGI:MGI:102764	Mouse	PMID:18775421
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hesx1	IDA		Mouse	PMID:17931718
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HESX1	IDA		Human	PMID:11748154
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hesx1	IDA		Mouse	MGI:MGI:5825430|PMID:17445765
Biological Process	GO:0043584	nose development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:9620767
Biological Process	GO:0030916	otic vesicle formation	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:9620767
Biological Process	GO:0021983	pituitary gland development	HESX1	IMP		Human	PMID:26781211
Biological Process	GO:0021983	pituitary gland development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:11731482
Biological Process	GO:0021983	pituitary gland development	Hesx1	IGI	MGI:MGI:102764	Mouse	PMID:18775421
Biological Process	GO:0021983	pituitary gland development	Hesx1	IMP	MGI:MGI:3822475	Mouse	PMID:19093031
Biological Process	GO:0021983	pituitary gland development	Hesx1	IMP	MGI:MGI:3822474	Mouse	PMID:19093031
Biological Process	GO:0021983	pituitary gland development	Hesx1	IMP	MGI:MGI:1931124	Mouse	PMID:9620767
Biological Process	GO:0021983	pituitary gland development	Hesx1	IMP		Mouse	PMID:20181723
Biological Process	GO:0045995	regulation of embryonic development	Hesx1	IMP		Mouse	PMID:31761678
Biological Process	GO:0048863	stem cell differentiation	Hesx1	IMP		Mouse	PMID:31761678
Biological Process	GO:0019827	stem cell population maintenance	Hesx1	IMP		Mouse	PMID:26188092
Biological Process	GO:0030878	thyroid gland development	Hesx1	IGI	MGI:MGI:102764	Mouse	PMID:18775421
Biological Process	GO:0016055	Wnt signaling pathway	Hesx1	IDA		Mouse	PMID:24520934

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern