Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HEY2
  • Mouse genes Hey2
  • Rat genes Hey2
  • Zfish genes hey2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hey2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Hey2	IMP		Mouse	MGI:MGI:3710697|PMID:11095750
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HEY2	IDA		Human	PMID:15485867
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hey2	IDA		Mouse	MGI:MGI:5284799|PMID:15485867
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HEY2	IDA		Human	PMID:21290414
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hey2	IDA		Mouse	MGI:MGI:3603871|PMID:16199874
Molecular Function	GO:0042826	histone deacetylase binding	HEY2	IPI	UniProtKB:Q96EB6	Human	PMID:12535671
Molecular Function	GO:0042802	identical protein binding	Hey2	IPI	PR:Q9QUS4	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:O75376	Human	PMID:11486045
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q60520	Human	PMID:11486045
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q96EB6	Human	PMID:12535671
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q9NQ87	Human	PMID:21454491
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:P42858	Human	PMID:23275563
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q5TD97	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q9BUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q9BYR3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q9BYR8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEY2	IPI	UniProtKB:Q9NR12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hey2	IPI	UniProtKB:Q9DBX7	Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0005515	protein binding	Hey2	IPI	UniProtKB:P43694	Mouse	MGI:MGI:5284799|PMID:15485867
Molecular Function	GO:0005515	protein binding	Hey2	IPI	UniProtKB:P43694|UniProtKB:Q92908	Mouse	MGI:MGI:3603871|PMID:16199874
Molecular Function	GO:0005515	protein binding	Hey2	IPI	UniProtKB:Q04666	Mouse	MGI:MGI:5142378|PMID:11486045
Molecular Function	GO:0005515	protein binding	Hey2	IPI	PR:Q60722	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	Hey2	IPI	PR:P15806	Mouse	PMID:11076679
Molecular Function	GO:0005515	protein binding	hey2	IPI	ZFIN:ZDB-GENE-980526-340	Zfish	PMID:17715064
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HEY2	IPI	UniProtKB:P27540	Human	PMID:10692439
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HEY2	IPI	UniProtKB:Q61169	Human	PMID:16293227
Molecular Function	GO:0043565	sequence-specific DNA binding	HEY2	IDA		Human	PMID:11486045
Molecular Function	GO:0043565	sequence-specific DNA binding	Hey2	IDA		Mouse	PMID:22615585
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HEY2	IDA		Human	PMID:28473536
Molecular Function	GO:0008134	transcription factor binding	Hey2	IPI	PR:Q08369	Mouse	PMID:16603706
Cellular Component	GO:0005737	cytoplasm	Hey2	IDA		Mouse	MGI:MGI:5285133|PMID:21290414
Cellular Component	GO:0005634	nucleus	Hey2	IDA		Mouse	MGI:MGI:5285133|PMID:21290414
Cellular Component	GO:0005634	nucleus	Hey2	IDA		Mouse	MGI:MGI:3710697|PMID:11095750
Cellular Component	GO:0005634	nucleus	Hey2	IDA		Rat	PMID:11741889|RGD:70528
Cellular Component	GO:0017053	transcription repressor complex	HEY2	IDA		Human	PMID:11486045
Biological Process	GO:0009948	anterior/posterior axis specification	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15680351
Biological Process	GO:0003180	aortic valve morphogenesis	Hey2	IDA		Mouse	MGI:MGI:6158746|PMID:22110751
Biological Process	GO:0060842	arterial endothelial cell differentiation	Hey2	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0060840	artery development	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15680351
Biological Process	GO:0060840	artery development	hey2	IMP	ZFIN:ZDB-MRPHLNO-060928-3	Zfish	PMID:20549735
Biological Process	GO:0048844	artery morphogenesis	hey2	IMP	ZFIN:ZDB-MRPHLNO-060928-3	Zfish	PMID:16753140
Biological Process	GO:0035910	ascending aorta morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0060413	atrial septum morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0003171	atrioventricular valve development	Hey2	IMP	MGI:MGI:3574394	Mouse	PMID:15297376
Biological Process	GO:0001568	blood vessel development	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15680351
Biological Process	GO:0001568	blood vessel development	hey2	IGI	ZFIN:ZDB-GENE-040109-4	Zfish	PMID:25834021
Biological Process	GO:0001568	blood vessel development	hey2	IMP	ZFIN:ZDB-GENO-980202-153	Zfish	PMID:15097998
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15107403
Biological Process	GO:0048514	blood vessel morphogenesis	hey2	IMP	ZFIN:ZDB-MRPHLNO-060928-3	Zfish	PMID:19815777
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	Hey2	IMP		Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20382855
Biological Process	GO:0060038	cardiac muscle cell proliferation	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:17332425
Biological Process	GO:0060038	cardiac muscle cell proliferation	hey2	IMP	ZFIN:ZDB-GENO-200311-1	Zfish	PMID:30355727
Biological Process	GO:0003300	cardiac muscle hypertrophy	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20382855
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Hey2	IDA		Mouse	PMID:16603706
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0060411	cardiac septum morphogenesis	Hey2	IMP		Mouse	MGI:MGI:3703467|PMID:17259303
Biological Process	GO:0060948	cardiac vascular smooth muscle cell development	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20619341
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Hey2	IMP		Mouse	MGI:MGI:3603871|PMID:16199874
Biological Process	GO:0045165	cell fate commitment	Hey2	IMP		Mouse	PMID:19154718
Biological Process	GO:0090102	cochlea development	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:18302773
Biological Process	GO:0090102	cochlea development	Hey2	IGI	MGI:MGI:104853	Mouse	PMID:18302773
Biological Process	GO:0090102	cochlea development	Hey2	IGI	MGI:MGI:104876	Mouse	PMID:18302773
Biological Process	GO:0060977	coronary vasculature morphogenesis	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20619341
Biological Process	GO:0035912	dorsal aorta morphogenesis	Hey2	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0035912	dorsal aorta morphogenesis	hey2	IMP	ZFIN:ZDB-GENO-980202-153	Zfish	PMID:10710309
Biological Process	GO:0035912	dorsal aorta morphogenesis	hey2	IMP	ZFIN:ZDB-GENO-980202-153	Zfish	PMID:7584985
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15680351
Biological Process	GO:0007507	heart development	Hey2	IEP		Rat	PMID:10692439|RGD:5132871
Biological Process	GO:0007507	heart development	hey2	IMP	ZFIN:ZDB-GENO-080117-10	Zfish	PMID:17715064
Biological Process	GO:0007507	heart development	hey2	IMP	ZFIN:ZDB-GENO-080401-2	Zfish	PMID:17715064
Biological Process	GO:0060347	heart trabecula formation	Hey2	IMP		Mouse	MGI:MGI:3703467|PMID:17259303
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Hey2	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0014031	mesenchymal cell development	Hey2	IMP		Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0003150	muscular septum morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0070168	negative regulation of biomineral tissue development	Hey2	IDA		Mouse	MGI:MGI:6158746|PMID:22110751
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20382855
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEY2	IDA		Human	PMID:12535671
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEY2	IDA		Human	PMID:15485867
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hey2	IMP		Mouse	MGI:MGI:3603871|PMID:16199874
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hey2	IDA		Mouse	MGI:MGI:5284799|PMID:15485867
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	hey2	IGI	ZFIN:ZDB-GENE-980526-340	Zfish	PMID:17715064
Biological Process	GO:0010629	negative regulation of gene expression	Hey2	IMP		Mouse	MGI:MGI:3604167|PMID:16025100
Biological Process	GO:0010629	negative regulation of gene expression	Hey2	IMP		Mouse	PMID:22615585
Biological Process	GO:0010629	negative regulation of gene expression	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20382855
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Hey2	IDA		Mouse	MGI:MGI:5284767|PMID:18239137
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Hey2	IMP		Mouse	MGI:MGI:3710697|PMID:11095750
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IDA		Human	PMID:10692439
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IMP		Human	PMID:11486045
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IDA		Human	PMID:12535671
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IDA		Human	PMID:16043483
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IDA		Human	PMID:16293227
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HEY2	IDA		Human	PMID:21290414
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IMP		Mouse	MGI:MGI:3604167|PMID:16025100
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IDA		Mouse	MGI:MGI:5285133|PMID:21290414
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IDA		Mouse	MGI:MGI:6158746|PMID:22110751
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IMP		Mouse	MGI:MGI:3703467|PMID:17259303
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IGI	MGI:MGI:99414	Mouse	PMID:20628571
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IGI	MGI:MGI:104853	Mouse	PMID:20628571
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IGI	MGI:MGI:99829	Mouse	PMID:20628571
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hey2	IDA		Mouse	PMID:10692439
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	Hey2	IDA		Mouse	MGI:MGI:5284767|PMID:18239137
Biological Process	GO:0060633	negative regulation of transcription initiation by RNA polymerase II	HEY2	IDA		Human	PMID:10692439
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	HEY2	IDA		Human	PMID:10692439
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Hey2	IDA		Mouse	MGI:MGI:5284767|PMID:18239137
Biological Process	GO:0007219	Notch signaling pathway	Hey2	IDA		Mouse	MGI:MGI:1889175|PMID:10964718
Biological Process	GO:0007219	Notch signaling pathway	Hey2	IDA		Rat	PMID:11741889|RGD:70528
Biological Process	GO:0060853	Notch signaling pathway involved in arterial endothelial cell fate commitment	hey2	IMP	ZFIN:ZDB-MRPHLNO-060928-3	Zfish	PMID:11700560
Biological Process	GO:0003151	outflow tract morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0007389	pattern specification process	Hey2	IGI	MGI:MGI:104853	Mouse	PMID:18302773
Biological Process	GO:0007389	pattern specification process	Hey2	IGI	MGI:MGI:104876	Mouse	PMID:18302773
Biological Process	GO:0007389	pattern specification process	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:18302773
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:17332425
Biological Process	GO:0010460	positive regulation of heart rate	Hey2	IMP	MGI:MGI:3574394	Mouse	PMID:15297376
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hey2	IMP		Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hey2	IMP		Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0065004	protein-DNA complex assembly	Hey2	IDA		Mouse	PMID:10692439
Biological Process	GO:0065004	protein-DNA complex assembly	Hey2	IDA		Mouse	PMID:16603706
Biological Process	GO:0061156	pulmonary artery morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0003184	pulmonary valve morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0010468	regulation of gene expression	Hey2	IMP	MGI:MGI:2447620	Mouse	PMID:20619341
Biological Process	GO:0045607	regulation of inner ear auditory receptor cell differentiation	Hey2	IGI	MGI:MGI:104654	Mouse	PMID:19154718
Biological Process	GO:2001212	regulation of vasculogenesis	Hey2	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0003195	tricuspid valve formation	Hey2	IMP	MGI:MGI:3574394	Mouse	PMID:15297376
Biological Process	GO:0003186	tricuspid valve morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0036304	umbilical cord morphogenesis	Hey2	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3040159|PMID:15107403
Biological Process	GO:0097084	vascular associated smooth muscle cell development	HEY2	IEP		Human	PMID:15821257
Biological Process	GO:0001570	vasculogenesis	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15107403
Biological Process	GO:0001570	vasculogenesis	hey2	IMP	ZFIN:ZDB-MRPHLNO-060928-3	Zfish	PMID:11700560
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Hey2	IMP		Mouse	MGI:MGI:3784153|PMID:17332425
Biological Process	GO:0060412	ventricular septum morphogenesis	Hey2	IMP		Mouse	MGI:MGI:2386835|PMID:12372254
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	Hey2	IGI	MGI:MGI:1341800	Mouse	PMID:15680351

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern