Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HEYL
  • Mouse genes Heyl
  • Rat genes Heyl
  • Zfish genes heyl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Heyl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050683	AF-1 domain binding	HEYL	IPI	UniProtKB:P10275	Human	PMID:21454491
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HEYL	IDA		Human	PMID:15485867
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HEYL	IDA		Human	PMID:21290414
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	HEYL	IDA		Human	PMID:21454491
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Heyl	IDA		Mouse	MGI:MGI:3603871|PMID:16199874
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:P43694	Human	PMID:15485867
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q93062	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q15788	Human	PMID:21454491
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q9UBP5	Human	PMID:21454491
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q9Y5J3	Human	PMID:21454491
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q99750	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q96KN7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q8N9N5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HEYL	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Heyl	IPI	UniProtKB:P35428|UniProtKB:P70120|UniProtKB:Q9DBX7|UniProtKB:Q9QUS4|UniProtKB:Q9WV93	Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0005515	protein binding	Heyl	IPI	UniProtKB:P43694|UniProtKB:Q92908	Mouse	MGI:MGI:3603871|PMID:16199874
Molecular Function	GO:0042803	protein homodimerization activity	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0043565	sequence-specific DNA binding	Heyl	IDA		Mouse	PMID:22615585
Cellular Component	GO:0005737	cytoplasm	Heyl	IDA		Mouse	MGI:MGI:5285133|PMID:21290414
Cellular Component	GO:0005634	nucleus	HEYL	IDA		Human	PMID:21454491
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Heyl	IMP		Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0071773	cellular response to BMP stimulus	Heyl	IEP		Mouse	MGI:MGI:5285519|PMID:21259317
Biological Process	GO:0003203	endocardial cushion morphogenesis	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	Heyl	IGI	MGI:MGI:1341800	Mouse	PMID:17303760
Biological Process	GO:0032835	glomerulus development	Heyl	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0014031	mesenchymal cell development	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	HEYL	IDA		Human	PMID:21454491
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	HEYL	IDA		Human	PMID:21454491
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEYL	IDA		Human	PMID:15485867
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HEYL	IDA		Human	PMID:21454491
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Heyl	IMP		Mouse	MGI:MGI:4365702|PMID:19631204
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Heyl	IMP		Mouse	MGI:MGI:3603871|PMID:16199874
Biological Process	GO:0010629	negative regulation of gene expression	Heyl	IMP		Mouse	PMID:22615585
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Biological Process	GO:0007219	Notch signaling pathway	HEYL	IDA		Human	PMID:10964718
Biological Process	GO:0003151	outflow tract morphogenesis	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0045666	positive regulation of neuron differentiation	Heyl	IMP		Mouse	MGI:MGI:4365702|PMID:19631204
Biological Process	GO:0045666	positive regulation of neuron differentiation	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HEYL	IDA		Human	PMID:21290414
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Heyl	IDA		Mouse	MGI:MGI:5285519|PMID:21259317
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0072014	proximal tubule development	Heyl	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0003184	pulmonary valve morphogenesis	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760
Biological Process	GO:0035914	skeletal muscle cell differentiation	Heyl	IMP		Mouse	PMID:22147266
Biological Process	GO:0060412	ventricular septum morphogenesis	Heyl	IGI	UniProtKB:Q9WV93	Mouse	MGI:MGI:3783952|PMID:17303760

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern