Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HFE
  • Mouse genes Hfe
  • Rat genes Hfe
  • Zfish genes mhc1zaa,mhc1zba,mhc1zca,mhc1zea,mhc1zfa,mhc1zja,mhc1zka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hfe

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030881	beta-2-microglobulin binding	HFE	IPI	UniProtKB:P61769	Human	PMID:9465039
Molecular Function	GO:0030881	beta-2-microglobulin binding	HFE	IPI	UniProtKB:P61769	Human	PMID:9546397
Molecular Function	GO:0030881	beta-2-microglobulin binding	HFE	IPI	UniProtKB:P61769	Human	PMID:9990067
Molecular Function	GO:0039706	co-receptor binding	HFE	IPI	UniProtKB:Q6ZVN8	Human	PMID:22728873
Molecular Function	GO:0039706	co-receptor binding	HFE	IPI	UniProtKB:Q96B86	Human	PMID:22728873
Molecular Function	GO:0005515	protein binding	HFE	IPI	UniProtKB:P02787	Human	PMID:15880641
Molecular Function	GO:0005515	protein binding	HFE	IPI	UniProtKB:P02786	Human	PMID:15965644
Molecular Function	GO:0005515	protein binding	HFE	IPI	UniProtKB:P61769	Human	PMID:15965644
Molecular Function	GO:0005515	protein binding	HFE	IPI	UniProtKB:P02786	Human	PMID:20618438
Molecular Function	GO:0005515	protein binding	HFE	IPI	UniProtKB:P61769	Human	PMID:20618438
Molecular Function	GO:0005102	signaling receptor binding	HFE	IPI	UniProtKB:P02786	Human	PMID:10638746
Molecular Function	GO:0005102	signaling receptor binding	HFE	IPI	UniProtKB:O00238	Human	PMID:24904118
Molecular Function	GO:0005102	signaling receptor binding	HFE	IPI	UniProtKB:P36894	Human	PMID:24904118
Molecular Function	GO:1990459	transferrin receptor binding	HFE	IPI	UniProtKB:Q9UP52	Human	PMID:18353247
Molecular Function	GO:1990459	transferrin receptor binding	HFE	IPI	UniProtKB:Q9UP52	Human	PMID:22728873
Molecular Function	GO:1990459	transferrin receptor binding	HFE	IPI	UniProtKB:P02786	Human	PMID:9465039
Molecular Function	GO:1990459	transferrin receptor binding	HFE	IPI	UniProtKB:P02786	Human	PMID:9546397
Molecular Function	GO:1990459	transferrin receptor binding	HFE	IPI	UniProtKB:P02786	Human	PMID:9990067
Molecular Function	GO:1990459	transferrin receptor binding	Hfe	IPI	UniProtKB:Q62351|UniProtKB:Q9JKX3	Mouse	MGI:MGI:3695785|PMID:16893896
Cellular Component	GO:0045177	apical part of cell	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:0045177	apical part of cell	Hfe	IDA		Rat	PMID:16208485|RGD:1582698
Cellular Component	GO:0045178	basal part of cell	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:0031410	cytoplasmic vesicle	HFE	IDA		Human	PMID:12704209
Cellular Component	GO:0031410	cytoplasmic vesicle	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:0005769	early endosome	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:0009897	external side of plasma membrane	HFE	IDA		Human	PMID:24904118
Cellular Component	GO:0005615	extracellular space	HFE	IDA		Human	PMID:21173098
Cellular Component	GO:1990712	HFE-transferrin receptor complex	HFE	IDA		Human	PMID:12704209
Cellular Component	GO:1990712	HFE-transferrin receptor complex	HFE	IDA		Human	PMID:22728873
Cellular Component	GO:1990712	HFE-transferrin receptor complex	HFE	IDA		Human	PMID:9465039
Cellular Component	GO:1990712	HFE-transferrin receptor complex	HFE	IDA		Human	PMID:9546397
Cellular Component	GO:1990712	HFE-transferrin receptor complex	HFE	IDA		Human	PMID:9990067
Cellular Component	GO:1990712	HFE-transferrin receptor complex	Hfe	IDA		Mouse	MGI:MGI:3695785|PMID:16893896
Cellular Component	GO:0005654	nucleoplasm	HFE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HFE	IDA		Human	PMID:9990067
Cellular Component	GO:0005886	plasma membrane	HFE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Hfe	IDA		Rat	PMID:29927322|RGD:14746968
Cellular Component	GO:0055037	recycling endosome	HFE	IDA		Human	PMID:15880641
Cellular Component	GO:1990357	terminal web	Hfe	IDA		Rat	PMID:16208485|RGD:1582698
Biological Process	GO:0006953	acute-phase response	Hfe	IEP		Rat	PMID:22469696|RGD:8694421
Biological Process	GO:0030509	BMP signaling pathway	HFE	IDA		Human	PMID:24904118
Biological Process	GO:0071281	cellular response to iron ion	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0010106	cellular response to iron ion starvation	Hfe	IEP		Rat	PMID:16208485|RGD:1582698
Biological Process	GO:0007565	female pregnancy	Hfe	IEP		Rat	PMID:15082582|RGD:1582699
Biological Process	GO:0042446	hormone biosynthetic process	Hfe	IMP	MGI:MGI:2385353	Mouse	PMID:15914561
Biological Process	GO:0006879	intracellular iron ion homeostasis	HFE	IDA		Human	PMID:10085150
Biological Process	GO:0006879	intracellular iron ion homeostasis	HFE	IDA		Human	PMID:18353247
Biological Process	GO:0097421	liver regeneration	Hfe	IEP		Rat	PMID:22364558|RGD:8694419
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	HFE	IMP		Human	PMID:21173098
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IMP	MGI:MGI:2181388	Mouse	PMID:10077651
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IMP	MGI:MGI:2385353	Mouse	PMID:15914561
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IMP		Mouse	PMID:21059897
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IMP	MGI:MGI:1934013	Mouse	PMID:15131800
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IMP	MGI:MGI:3775648	Mouse	PMID:22960056
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Hfe	IEP		Rat	PMID:15082582|RGD:1582699
Biological Process	GO:1904283	negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I	HFE	IGI	UniProtKB:P04439	Human	PMID:24643698
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	HFE	IGI	UniProtKB:P04439	Human	PMID:24643698
Biological Process	GO:1900121	negative regulation of receptor binding	HFE	IDA		Human	PMID:9465039
Biological Process	GO:2000272	negative regulation of signaling receptor activity	HFE	IDA		Human	PMID:9465039
Biological Process	GO:0002725	negative regulation of T cell cytokine production	HFE	IGI	UniProtKB:P04439	Human	PMID:24643698
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	HFE	IDA		Human	PMID:24904118
Biological Process	GO:1904434	positive regulation of ferrous iron binding	HFE	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0010628	positive regulation of gene expression	Hfe	IMP		Mouse	MGI:MGI:5603002|PMID:24904118
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	HFE	IDA		Human	PMID:24904118
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	HFE	IMP		Human	PMID:21173098
Biological Process	GO:0032092	positive regulation of protein binding	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:1900122	positive regulation of receptor binding	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:2000273	positive regulation of signaling receptor activity	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:1904437	positive regulation of transferrin receptor binding	HFE	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0034756	regulation of iron ion transport	HFE	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0034756	regulation of iron ion transport	HFE	IGI	UniProtKB:P02787,UniProtKB:P61769,UniProtKB:Q07891,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:2000008	regulation of protein localization to cell surface	HFE	IMP		Human	PMID:12704209
Biological Process	GO:0010039	response to iron ion	HFE	IMP		Human	PMID:21173098
Biological Process	GO:1990641	response to iron ion starvation	Hfe	IEP		Rat	PMID:16208485|RGD:1582698

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern