Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HGF
  • Mouse genes Hgf
  • Rat genes Hgf
  • Zfish genes hgfa,hgfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hgf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042056	chemoattractant activity	HGF	IDA		Human	PMID:21245381
Molecular Function	GO:0008083	growth factor activity	Hgf	IMP		Rat	PMID:1826679|RGD:1642061
Molecular Function	GO:0042802	identical protein binding	HGF	IPI	UniProtKB:P14210	Human	PMID:17804794
Molecular Function	GO:0042802	identical protein binding	HGF	IPI	UniProtKB:P14210	Human	PMID:20624990
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P43025	Human	PMID:12694198
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P08581	Human	PMID:15167892
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P08581	Human	PMID:16537482
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P08581	Human	PMID:17804794
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P08581	Human	PMID:17981115
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P08581	Human	PMID:1846706
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P16056	Human	PMID:18585357
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HGF	IPI	UniProtKB:Q6UY14-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Hgf	IPI	UniProtKB:P08581	Mouse	MGI:MGI:6093276|PMID:17804794
Molecular Function	GO:0044877	protein-containing complex binding	Hgf	IDA		Rat	PMID:1826679|RGD:1642061
Cellular Component	GO:0005615	extracellular space	Hgf	IDA		Rat	PMID:19638569|RGD:2313572
Cellular Component	GO:0016020	membrane	HGF	HDA		Human	PMID:19946888
Biological Process	GO:0031100	animal organ regeneration	Hgf	IEP		Rat	PMID:19638569|RGD:2313572
Biological Process	GO:0060326	cell chemotaxis	HGF	IDA		Human	PMID:21245381
Biological Process	GO:0000902	cell morphogenesis	Hgf	IDA		Mouse	PMID:12130561
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	HGF	IDA		Human	PMID:21245381
Biological Process	GO:0021953	central nervous system neuron differentiation	hgfa	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021953	central nervous system neuron differentiation	hgfb	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021707	cerebellar granule cell differentiation	hgfa	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021707	cerebellar granule cell differentiation	hgfb	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021549	cerebellum development	hgfa	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021549	cerebellum development	hgfb	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021587	cerebellum morphogenesis	hgfa	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021587	cerebellum morphogenesis	hgfb	IGI	ZFIN:ZDB-MRPHLNO-100420-3,ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0021603	cranial nerve formation	hgfa	IMP	ZFIN:ZDB-GENO-211102-14	Zfish	PMID:32302545
Biological Process	GO:0050673	epithelial cell proliferation	Hgf	IDA		Mouse	PMID:12130561
Biological Process	GO:0050673	epithelial cell proliferation	Hgf	IDA		Mouse	PMID:15314156
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway	HGF	IDA		Human	PMID:21245381
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway	Hgf	IDA		Mouse	PMID:15314156
Biological Process	GO:0001889	liver development	Hgf	IDA		Mouse	PMID:16880525
Biological Process	GO:0051450	myoblast proliferation	Hgf	IDA		Mouse	PMID:11061428
Biological Process	GO:0043066	negative regulation of apoptotic process	Hgf	IDA		Rat	PMID:16885537|RGD:1642707
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	HGF	IDA		Human	PMID:20655899
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hgf	IDA		Mouse	PMID:15314156
Biological Process	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	HGF	IDA		Human	PMID:20655899
Biological Process	GO:0050728	negative regulation of inflammatory response	Hgf	IDA		Mouse	PMID:21072211
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Hgf	IDA		Mouse	PMID:21072211
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Hgf	IDA		Mouse	PMID:21072211
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	HGF	IDA		Human	PMID:20655899
Biological Process	GO:0001764	neuron migration	hgfa	IMP	ZFIN:ZDB-MRPHLNO-100420-4	Zfish	PMID:19732764
Biological Process	GO:0001764	neuron migration	hgfb	IMP	ZFIN:ZDB-MRPHLNO-100420-3	Zfish	PMID:19732764
Biological Process	GO:0045766	positive regulation of angiogenesis	Hgf	IDA		Rat	PMID:17549731|RGD:2317487
Biological Process	GO:0030335	positive regulation of cell migration	HGF	IDA		Human	PMID:21245381
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	HGF	IDA		Human	PMID:2531289
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Hgf	IDA		Mouse	PMID:21072211
Biological Process	GO:0043410	positive regulation of MAPK cascade	Hgf	IDA		Mouse	PMID:15314156
Biological Process	GO:0031643	positive regulation of myelination	Hgf	IDA		Rat	PMID:17549731|RGD:2317487
Biological Process	GO:0070572	positive regulation of neuron projection regeneration	Hgf	IDA		Rat	PMID:17549731|RGD:2317487
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	HGF	IDA		Human	PMID:21245381
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	HGF	IDA		Human	PMID:20655899
Biological Process	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	HGF	IDA		Human	PMID:14517989
Biological Process	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	Hgf	IMP		Mouse	PMID:14517989
Biological Process	GO:1900744	regulation of p38MAPK cascade	Hgf	IDA		Mouse	PMID:23994610
Biological Process	GO:1902947	regulation of tau-protein kinase activity	Hgf	IDA		Mouse	PMID:21072211
Biological Process	GO:0014856	skeletal muscle cell proliferation	Hgf	IDA		Mouse	PMID:11061428

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern