Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HHEX
  • Mouse genes Hhex
  • Rat genes Hhex
  • Zfish genes hhex
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hhex

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hhex	IDA		Mouse	PMID:16764824
Molecular Function	GO:0008301	DNA binding, bending	HHEX	IDA		Human	PMID:18755198
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HHEX	IMP		Human	PMID:20028982
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hhex	IDA		Mouse	MGI:MGI:4418635|PMID:11139473
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HHEX	IPI	UniProtKB:P23769	Human	PMID:15016828
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HHEX	IPI	UniProtKB:P23771	Human	PMID:15016828
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HHEX	IPI	UniProtKB:Q92908	Human	PMID:15016828
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HHEX	IDA		Human	PMID:15187083
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	HHEX	IDA		Human	PMID:15016828
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hhex	IDA		Mouse	MGI:MGI:3640450|PMID:16764824
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	HHEX	IDA		Human	PMID:12554669
Molecular Function	GO:0071837	HMG box domain binding	Hhex	IPI	UniProtKB:O55170|UniProtKB:Q05066	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P29590-4	Human	PMID:10597310
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P25788	Human	PMID:12826010
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P67870	Human	PMID:19324893
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q9UN79	Human	PMID:20028982
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P60370	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:O43586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:O75690	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P60371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q05BL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q15415	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q5VWX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q6L8G8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q8IUB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q8IZP0-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q9BYR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q9NRW3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:Q9NYB9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HHEX	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hhex	IPI	UniProtKB:Q04891	Mouse	MGI:MGI:4460849|PMID:20028982
Molecular Function	GO:0042803	protein homodimerization activity	HHEX	IPI	UniProtKB:Q03014	Human	PMID:16540119
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HHEX	IDA		Human	PMID:15016828
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Hhex	IDA		Mouse	MGI:MGI:3640450|PMID:16764824
Molecular Function	GO:0043565	sequence-specific DNA binding	HHEX	IDA		Human	PMID:10871399
Molecular Function	GO:0043565	sequence-specific DNA binding	Hhex	IDA		Rat	PMID:11139473|RGD:2314899
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HHEX	IDA		Human	PMID:18755198
Cellular Component	GO:0005737	cytoplasm	HHEX	IDA		Human	PMID:12554669
Cellular Component	GO:0005737	cytoplasm	HHEX	IDA		Human	PMID:12826010
Cellular Component	GO:0005737	cytoplasm	Hhex	IDA		Mouse	PMID:16854221
Cellular Component	GO:0005634	nucleus	HHEX	IDA		Human	PMID:12554669
Cellular Component	GO:0005634	nucleus	HHEX	IDA		Human	PMID:12588764
Cellular Component	GO:0005634	nucleus	HHEX	IDA		Human	PMID:12826010
Cellular Component	GO:0005634	nucleus	Hhex	IDA		Mouse	PMID:11044484
Cellular Component	GO:0005634	nucleus	Hhex	IDA		Mouse	PMID:16854221
Cellular Component	GO:0005634	nucleus	Hhex	IDA		Rat	PMID:11139473|RGD:2314899
Cellular Component	GO:0032993	protein-DNA complex	HHEX	IDA		Human	PMID:18755198
Biological Process	GO:0009887	animal organ morphogenesis	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:14736744
Biological Process	GO:0009952	anterior/posterior pattern specification	Hhex	IMP		Mouse	MGI:MGI:3777521|PMID:16936074
Biological Process	GO:0030183	B cell differentiation	Hhex	IMP	MGI:MGI:2449914	Mouse	PMID:12522149
Biological Process	GO:0030154	cell differentiation	Hhex	IDA		Rat	PMID:10085234|RGD:625370
Biological Process	GO:0061009	common bile duct development	Hhex	IMP	MGI:MGI:3721426	Mouse	PMID:17580084
Biological Process	GO:0007368	determination of left/right symmetry	hhex	IMP		Zfish	PMID:11477693|ZFIN:ZDB-PUB-010807-12
Biological Process	GO:0048565	digestive tract development	hhex	IMP		Zfish	PMID:11477693|ZFIN:ZDB-PUB-010807-12
Biological Process	GO:0071103	DNA conformation change	HHEX	IDA		Human	PMID:18755198
Biological Process	GO:0009953	dorsal/ventral pattern formation	hhex	IMP		Zfish	PMID:10531010|ZFIN:ZDB-PUB-991102-7
Biological Process	GO:0035050	embryonic heart tube development	Hhex	IMP	MGI:MGI:2449914	Mouse	PMID:15459110
Biological Process	GO:0035162	embryonic hemopoiesis	hhex	IMP		Zfish	PMID:11003831|ZFIN:ZDB-PUB-001130-2
Biological Process	GO:0048568	embryonic organ development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0007492	endoderm development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0031017	exocrine pancreas development	hhex	IMP	ZFIN:ZDB-MRPHLNO-160621-29	Zfish	PMID:26963759
Biological Process	GO:0030900	forebrain development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:10804184
Biological Process	GO:0030900	forebrain development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:11291863
Biological Process	GO:0030900	forebrain development	Hhex	IMP	MGI:MGI:2449914	Mouse	PMID:15459110
Biological Process	GO:0048853	forebrain morphogenesis	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0061010	gallbladder development	Hhex	IMP	MGI:MGI:3721426	Mouse	PMID:17580084
Biological Process	GO:0007507	heart development	hhex	IMP		Zfish	PMID:14568547
Biological Process	GO:0030097	hemopoiesis	Hhex	IMP		Mouse	PMID:15728128
Biological Process	GO:0030097	hemopoiesis	Hhex	IMP		Mouse	PMID:12791650
Biological Process	GO:0061011	hepatic duct development	Hhex	IMP	MGI:MGI:3721426	Mouse	PMID:17580084
Biological Process	GO:0061008	hepaticobiliary system development	hhex	IMP	ZFIN:ZDB-GENO-210311-4	Zfish	PMID:31697936
Biological Process	GO:0061017	hepatoblast differentiation	Hhex	IMP	MGI:MGI:3721426	Mouse	PMID:17580084
Biological Process	GO:0070365	hepatocyte differentiation	Hhex	IMP	MGI:MGI:2448661	Mouse	PMID:11027604
Biological Process	GO:0001701	in utero embryonic development	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0022027	interkinetic nuclear migration	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0001889	liver development	Hhex	IMP	MGI:MGI:2449914	Mouse	PMID:15459110
Biological Process	GO:0001889	liver development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:10804184
Biological Process	GO:0001889	liver development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0001889	liver development	Hhex	IMP	MGI:MGI:2448661	Mouse	PMID:11027604
Biological Process	GO:0001889	liver development	hhex	IMP		Zfish	PMID:11477693|ZFIN:ZDB-PUB-010807-12
Biological Process	GO:0001889	liver development	hhex	IMP		Zfish	PMID:12633865
Biological Process	GO:0072576	liver morphogenesis	hhex	IMP	ZFIN:ZDB-GENO-200730-4	Zfish	PMID:30428031
Biological Process	GO:0001946	lymphangiogenesis	hhex	IMP	ZFIN:ZDB-GENO-200324-3	Zfish	PMID:30006544
Biological Process	GO:0001946	lymphangiogenesis	hhex	IMP	ZFIN:ZDB-GENO-181011-9	Zfish	PMID:30006544
Biological Process	GO:0002009	morphogenesis of an epithelium	Hhex	IMP	MGI:MGI:3721426	Mouse	PMID:17580084
Biological Process	GO:0006406	mRNA export from nucleus	HHEX	IDA		Human	PMID:12554669
Biological Process	GO:0035264	multicellular organism growth	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0002573	myeloid leukocyte differentiation	Hhex	IMP	MGI:MGI:2448661	Mouse	PMID:11027604
Biological Process	GO:0016525	negative regulation of angiogenesis	Hhex	IDA		Mouse	MGI:MGI:3777525|PMID:12588764
Biological Process	GO:0016525	negative regulation of angiogenesis	Hhex	IDA		Rat	PMID:15016828|RGD:8554322
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	HHEX	IDA		Human	PMID:12554669
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HHEX	IDA		Human	PMID:10871399
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HHEX	IDA		Human	PMID:15016828
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hhex	IDA		Mouse	MGI:MGI:3777527|PMID:10804173
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Hhex	IDA		Rat	PMID:10085234|RGD:625370
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	hhex	IDA		Zfish	PMID:10531010|ZFIN:ZDB-PUB-991102-7
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HHEX	IDA		Human	PMID:10871399
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HHEX	IDA		Human	PMID:15016828
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hhex	IDA		Mouse	MGI:MGI:3777525|PMID:12588764
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hhex	IDA		Mouse	PMID:10804173
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hhex	IDA		Mouse	PMID:16764824
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hhex	IDA		Rat	PMID:15016828|RGD:8554322
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	hhex	IDA		Zfish	PMID:10531010|ZFIN:ZDB-PUB-991102-7
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Hhex	IDA		Mouse	MGI:MGI:3777525|PMID:12588764
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Hhex	IDA		Rat	PMID:15016828|RGD:8554322
Biological Process	GO:0007219	Notch signaling pathway	Hhex	IDA		Mouse	PMID:25446530
Biological Process	GO:0031016	pancreas development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0016973	poly(A)+ mRNA export from nucleus	HHEX	IMP		Human	PMID:12554669
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	HHEX	IMP		Human	PMID:20028982
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HHEX	IMP		Human	PMID:20028982
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	hhex	IMP		Zfish	PMID:11003831
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HHEX	IDA		Human	PMID:12655000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HHEX	IMP		Human	PMID:20028982
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Hhex	IMP		Mouse	MGI:MGI:3777521|PMID:16936074
Biological Process	GO:0060431	primary lung bud formation	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:16364283
Biological Process	GO:0090009	primitive streak formation	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0090009	primitive streak formation	Hhex	IGI	MGI:MGI:97359	Mouse	PMID:21445260
Biological Process	GO:0034504	protein localization to nucleus	HHEX	IDA		Human	PMID:18713067
Biological Process	GO:0042127	regulation of cell population proliferation	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:14736744
Biological Process	GO:0070663	regulation of leukocyte proliferation	HHEX	IDA		Human	PMID:12554669
Biological Process	GO:0046620	regulation of organ growth	hhex	IMP		Zfish	PMID:14568547
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0043434	response to peptide hormone	Hhex	IEP		Rat	PMID:10871399|RGD:2314901
Biological Process	GO:0009611	response to wounding	Hhex	IEP		Rat	PMID:11139473|RGD:2314899
Biological Process	GO:0007165	signal transduction	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0002040	sprouting angiogenesis	hhex	IMP	ZFIN:ZDB-GENO-181011-9	Zfish	PMID:30006544
Biological Process	GO:0002040	sprouting angiogenesis	hhex	IMP	ZFIN:ZDB-GENO-181011-8	Zfish	PMID:30006544
Biological Process	GO:0002040	sprouting angiogenesis	hhex	IMP	ZFIN:ZDB-GENO-181011-9,ZFIN:ZDB-GENO-200324-6	Zfish	PMID:30006544
Biological Process	GO:0030878	thyroid gland development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:15581879
Biological Process	GO:0030878	thyroid gland development	Hhex	IMP	MGI:MGI:2177762	Mouse	PMID:10804184
Biological Process	GO:0030878	thyroid gland development	hhex	IMP	ZFIN:ZDB-GENO-980202-332	Zfish	PMID:14568547
Biological Process	GO:0048729	tissue morphogenesis	Hhex	IMP	MGI:MGI:4999724	Mouse	PMID:21445260
Biological Process	GO:0001570	vasculogenesis	Hhex	IMP		Mouse	PMID:15728128
Biological Process	GO:0001570	vasculogenesis	Hhex	IMP		Mouse	PMID:12791650

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern