Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HIF3A
  • Mouse genes Hif3a
  • Rat genes Hif3a
  • Zfish genes hif1al
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hif3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	hif1al	IDA		Zfish	PMID:26765566
Molecular Function	GO:0003677	DNA binding	Hif3a	IPI	UniProtKB:P35869	Mouse	PMID:9840812
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hif3a	IPI	UniProtKB:P35869	Mouse	PMID:9840812
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hif3a	IDA		Rat	PMID:11237857|RGD:68201
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HIF3A	IDA		Human	PMID:11573933
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	HIF3A	IDA		Human	PMID:31768607
Molecular Function	GO:0005515	protein binding	Hif3a	IPI	UniProtKB:Q61221	Mouse	MGI:MGI:5526927|PMID:21546903
Molecular Function	GO:0005515	protein binding	Hif3a	IPI	UniProtKB:P70345|UniProtKB:P97287|UniProtKB:P97481|UniProtKB:Q61221|UniProtKB:Q61337	Mouse	MGI:MGI:5526927|PMID:21546903
Molecular Function	GO:0005515	protein binding	Hif3a	IPI	RGD:2200	Rat	PMID:21546903|RGD:11353811
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HIF3A	IDA		Human	PMID:31768607
Molecular Function	GO:0000976	transcription cis-regulatory region binding	hif1al	IDA		Zfish	PMID:24613356
Cellular Component	GO:1990907	beta-catenin-TCF complex	hif1al	IPI	ZFIN:ZDB-GENE-090814-1,ZFIN:ZDB-GENE-990714-26	Zfish	PMID:26765566
Cellular Component	GO:0000785	chromatin	HIF3A	IDA		Human	PMID:31768607
Cellular Component	GO:0005737	cytoplasm	Hif3a	IDA		Mouse	MGI:MGI:5526927|PMID:21546903
Cellular Component	GO:0005737	cytoplasm	Hif3a	IDA		Rat	PMID:11237857|RGD:68201
Cellular Component	GO:0005829	cytosol	HIF3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Hif3a	IDA		Mouse	MGI:MGI:5526927|PMID:21546903
Cellular Component	GO:0016607	nuclear speck	Hif3a	IDA		Mouse	MGI:MGI:5526927|PMID:21546903
Cellular Component	GO:0005654	nucleoplasm	HIF3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Hif3a	IDA		Mouse	MGI:MGI:5526927|PMID:21546903
Cellular Component	GO:0005634	nucleus	Hif3a	IDA		Rat	PMID:11237857|RGD:68201
Cellular Component	GO:0005634	nucleus	hif1al	IDA		Zfish	PMID:23034716
Cellular Component	GO:0005886	plasma membrane	HIF3A	IDA		Human	GO_REF:0000052
Biological Process	GO:0048821	erythrocyte development	hif1al	IMP	ZFIN:ZDB-GENO-220510-11	Zfish	PMID:33037038
Biological Process	GO:0048821	erythrocyte development	hif1al	IMP	ZFIN:ZDB-FISH-220510-17	Zfish	PMID:33037038
Biological Process	GO:0001654	eye development	hif1al	IMP	ZFIN:ZDB-GENO-160609-3,ZFIN:ZDB-MRPHLNO-160421-1	Zfish	PMID:26765566
Biological Process	GO:0001654	eye development	hif1al	IMP	ZFIN:ZDB-MRPHLNO-160421-1	Zfish	PMID:26765566
Biological Process	GO:0051402	neuron apoptotic process	hif1al	IGI	ZFIN:ZDB-MRPHLNO-100414-7,ZFIN:ZDB-MRPHLNO-100414-8,ZFIN:ZDB-MRPHLNO-100610-11	Zfish	PMID:19123687
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hif3a	IDA		Rat	PMID:11237857|RGD:68201
Biological Process	GO:0006355	regulation of DNA-templated transcription	hif1al	IDA		Zfish	PMID:24613356
Biological Process	GO:0014823	response to activity	hif1al	IEP		Zfish	PMID:21343420
Biological Process	GO:0001666	response to hypoxia	Hif3a	IDA		Mouse	PMID:9840812
Biological Process	GO:0001666	response to hypoxia	hif1al	IDA		Zfish	PMID:24613356
Biological Process	GO:0006366	transcription by RNA polymerase II	Hif3a	IPI	UniProtKB:P35869	Mouse	PMID:9840812

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern