Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hip1r

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HIP1R
- Mouse genes Hip1r
- Rat genes Hip1r
- Zfish genes hip1rb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hip1r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Hip1r	IDA		Mouse	PMID:10613908
Molecular Function	GO:0051015	actin filament binding	HIP1R	IDA		Human	PMID:16415883
Molecular Function	GO:0051015	actin filament binding	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Molecular Function	GO:0051015	actin filament binding	Hip1r	IDA		Mouse	MGI:MGI:5805365\|PMID:18790740
Molecular Function	GO:0035615	clathrin adaptor activity	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Molecular Function	GO:0030276	clathrin binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0030276	clathrin binding	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Molecular Function	GO:0032051	clathrin light chain binding	Hip1r	IPI	UniProtKB:P04973\|UniProtKB:P04975	Mouse	MGI:MGI:5763378\|PMID:15533940
Molecular Function	GO:0032051	clathrin light chain binding	Hip1r	IPI	UniProtKB:P04975	Mouse	MGI:MGI:5805365\|PMID:18790740
Molecular Function	GO:0042802	identical protein binding	HIP1R	IPI	UniProtKB:O75146	Human	PMID:16415883
Molecular Function	GO:0035091	phosphatidylinositol binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	HIP1R	IDA		Human	PMID:14732715
Molecular Function	GO:0005515	protein binding	HIP1R	IPI	UniProtKB:O00291	Human	PMID:11889126
Molecular Function	GO:0005515	protein binding	HIP1R	IPI	UniProtKB:P04975	Human	PMID:11889126
Molecular Function	GO:0005515	protein binding	HIP1R	IPI	UniProtKB:P09497	Human	PMID:11889126
Molecular Function	GO:0005515	protein binding	HIP1R	IPI	UniProtKB:Q9HD36	Human	PMID:19255499
Molecular Function	GO:0005515	protein binding	Hip1r	IPI	UniProtKB:Q60598	Mouse	MGI:MGI:5805366\|PMID:17318189
Molecular Function	GO:0005515	protein binding	Hip1r	IPI	UniProtKB:G3V6K6	Mouse	MGI:MGI:6791035\|PMID:30574069
Molecular Function	GO:0005515	protein binding	Hip1r	IPI	UniProtKB:Q96B97	Mouse	MGI:MGI:5508276\|PMID:15090612
Molecular Function	GO:0046982	protein heterodimerization activity	Hip1r	IPI	UniProtKB:O00291	Mouse	MGI:MGI:5763378\|PMID:15533940
Molecular Function	GO:0042803	protein homodimerization activity	HIP1R	IPI	UniProtKB:O75146	Human	PMID:16415883
Molecular Function	GO:0042803	protein homodimerization activity	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Molecular Function	GO:0042803	protein homodimerization activity	Hip1r	IDA		Mouse	MGI:MGI:5805365\|PMID:18790740
Molecular Function	GO:0042803	protein homodimerization activity	Hip1r	IDA		Mouse	MGI:MGI:5763378\|PMID:15533940
Molecular Function	GO:0017124	SH3 domain binding	Hip1r	IDA		Mouse	MGI:MGI:5805366\|PMID:17318189
Cellular Component	GO:0016324	apical plasma membrane	Hip1r	IDA		Mouse	MGI:MGI:3801545\|PMID:18535670
Cellular Component	GO:0005938	cell cortex	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Cellular Component	GO:0005905	clathrin-coated pit	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Cellular Component	GO:0005905	clathrin-coated pit	Hip1r	IDA		Mouse	PMID:10613908
Cellular Component	GO:0030136	clathrin-coated vesicle	HIP1R	IDA		Human	PMID:11889126
Cellular Component	GO:0030136	clathrin-coated vesicle	HIP1R	IDA		Human	PMID:14732715
Cellular Component	GO:0030136	clathrin-coated vesicle	Hip1r	IDA		Mouse	MGI:MGI:1351058\|PMID:10613908
Cellular Component	GO:0005856	cytoskeleton	Hip1r	IDA		Mouse	PMID:10613908
Cellular Component	GO:0005829	cytosol	HIP1R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098978	glutamatergic synapse	Hip1r	IDA		Rat	PMID:12650982\|RGD:708599
Cellular Component	GO:0098978	glutamatergic synapse	Hip1r	IDA		Rat	PMID:28663723\|RGD:155230757
Cellular Component	GO:0098978	glutamatergic synapse	Hip1r	IMP		Rat	PMID:28663723\|RGD:155230757
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HIP1R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Hip1r	IDA		Rat	PMID:12650982\|RGD:708599
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Hip1r	IDA		Mouse	MGI:MGI:1351058\|PMID:10613908
Cellular Component	GO:0005886	plasma membrane	HIP1R	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098794	postsynapse	Hip1r	IDA		Rat	PMID:12650982\|RGD:708599
Cellular Component	GO:0032587	ruffle membrane	HIP1R	IDA		Human	PMID:14732715
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	HIP1R	IDA		Human	PMID:19255499
Biological Process	GO:0048268	clathrin coat assembly	Hip1r	IDA		Mouse	MGI:MGI:5805370\|PMID:11564758
Biological Process	GO:0055123	digestive system development	Hip1r	IMP		Mouse	MGI:MGI:3801545\|PMID:18535670
Biological Process	GO:0061024	membrane organization	Hip1r	IMP		Mouse	MGI:MGI:3801545\|PMID:18535670
Biological Process	GO:0030837	negative regulation of actin filament polymerization	HIP1R	IMP		Human	PMID:17318189
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Hip1r	IDA		Mouse	MGI:MGI:5805366\|PMID:17318189
Biological Process	GO:0043066	negative regulation of apoptotic process	Hip1r	IMP		Mouse	MGI:MGI:3801545\|PMID:18535670
Biological Process	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	Hip1r	IDA		Mouse	MGI:MGI:5805366\|PMID:17318189
Biological Process	GO:0043065	positive regulation of apoptotic process	HIP1R	IGI	UniProtKB:O08734	Human	PMID:19255499
Biological Process	GO:1905445	positive regulation of clathrin coat assembly	Hip1r	IDA		Mouse	MGI:MGI:5763378\|PMID:15533940
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	HIP1R	IMP		Human	PMID:14732715
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	HIP1R	IGI	UniProtKB:Q9HD36	Human	PMID:19255499
Biological Process	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway	HIP1R	IMP		Human	PMID:14732715
Biological Process	GO:0032092	positive regulation of protein binding	HIP1R	IDA		Human	PMID:19255499
Biological Process	GO:0099173	postsynapse organization	Hip1r	IDA		Rat	PMID:28663723\|RGD:155230757
Biological Process	GO:0099173	postsynapse organization	Hip1r	IMP		Rat	PMID:28663723\|RGD:155230757
Biological Process	GO:0050821	protein stabilization	HIP1R	IDA		Human	PMID:14732715
Biological Process	GO:0006898	receptor-mediated endocytosis	HIP1R	IMP		Human	PMID:11889126
Biological Process	GO:0006898	receptor-mediated endocytosis	Hip1r	IDA		Mouse	PMID:10613908
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	HIP1R	IMP		Human	PMID:14742709
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Hip1r	IGI	UniProtKB:O75146	Mouse	MGI:MGI:5805367\|PMID:14742709
Biological Process	GO:0030100	regulation of endocytosis	HIP1R	IMP		Human	PMID:14742709
Biological Process	GO:0060453	regulation of gastric acid secretion	Hip1r	IMP		Mouse	MGI:MGI:3801545\|PMID:18535670

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.