Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hipk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HIPK2
- Mouse genes Hipk2
- Rat genes Hipk2
- Zfish genes hipk2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hipk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q96S59	Human	PMID:12220523
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:P12755	Human	PMID:12874272
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:P23497	Human	PMID:14647468
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q01196	Human	PMID:16917507
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q09472	Human	PMID:16917507
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q9P1Z0	Human	PMID:19448668
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:P51608	Human	PMID:19820693
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:P61962	Human	PMID:20940704
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q9H3D4	Human	PMID:21602882
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:P56545	Human	PMID:23393140
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:G2XKQ0	Human	PMID:27211601
Molecular Function	GO:0005515	protein binding	HIPK2	IPI	UniProtKB:Q15038	Human	PMID:33591310
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	UniProtKB:Q8CFN5	Mouse	MGI:MGI:5494340\|PMID:23565059
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	UniProtKB:O54949\|UniProtKB:P06876	Mouse	MGI:MGI:3040155\|PMID:15082531
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	UniProtKB:P42580\|UniProtKB:P42582	Mouse	MGI:MGI:1303245\|PMID:9748262
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	UniProtKB:P51608	Mouse	MGI:MGI:4457848\|PMID:19820693
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	UniProtKB:Q9Y6I7	Mouse	MGI:MGI:3829121\|PMID:18093972
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	PR:P15702	Mouse	PMID:20360400
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	PR:P17208	Mouse	PMID:15492043
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	PR:P02340	Mouse	PMID:15526030
Molecular Function	GO:0005515	protein binding	Hipk2	IPI	PR:O35625	Mouse	PMID:15526030
Molecular Function	GO:0004672	protein kinase activity	HIPK2	IDA		Human	PMID:19448668
Molecular Function	GO:0004672	protein kinase activity	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Molecular Function	GO:0004674	protein serine/threonine kinase activity	HIPK2	IDA		Human	PMID:33591310
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Hipk2	IDA		Mouse	MGI:MGI:5306308\|PMID:16407227
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hipk2	IPI	UniProtKB:P63015	Mouse	MGI:MGI:5306308\|PMID:16407227
Molecular Function	GO:0046332	SMAD binding	HIPK2	IPI	UniProtKB:P84022	Human	PMID:12874272
Molecular Function	GO:0046332	SMAD binding	HIPK2	IPI	UniProtKB:Q15797	Human	PMID:12874272
Molecular Function	GO:0003713	transcription coactivator activity	Hipk2	IMP		Mouse	MGI:MGI:5306308\|PMID:16407227
Molecular Function	GO:0003714	transcription corepressor activity	HIPK2	IDA		Human	PMID:12874272
Molecular Function	GO:0003714	transcription corepressor activity	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Molecular Function	GO:0046790	virion binding	HIPK2	IPI	UniProtKB:P04487	Human	PMID:14990717
Cellular Component	GO:0005737	cytoplasm	HIPK2	IDA		Human	PMID:33591310
Cellular Component	GO:0005737	cytoplasm	Hipk2	IDA		Mouse	PMID:11078605
Cellular Component	GO:0010494	cytoplasmic stress granule	HIPK2	IDA		Human	PMID:33591310
Cellular Component	GO:0016604	nuclear body	HIPK2	IDA		Human	PMID:12874272
Cellular Component	GO:0016604	nuclear body	HIPK2	IDA		Human	PMID:33591310
Cellular Component	GO:0005654	nucleoplasm	HIPK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HIPK2	IDA		Human	PMID:12220523
Cellular Component	GO:0005634	nucleus	HIPK2	IDA		Human	PMID:14647468
Cellular Component	GO:0005634	nucleus	HIPK2	IDA		Human	PMID:33591310
Cellular Component	GO:0005634	nucleus	Hipk2	IDA		Mouse	MGI:MGI:4818711\|PMID:20579985
Cellular Component	GO:0005634	nucleus	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Cellular Component	GO:0016605	PML body	HIPK2	IDA		Human	PMID:14647468
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Hipk2	IMP		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0008344	adult locomotory behavior	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989
Biological Process	GO:0007628	adult walking behavior	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989
Biological Process	GO:0009952	anterior/posterior pattern specification	Hipk2	IGI	MGI:MGI:1314872	Mouse	PMID:16537918
Biological Process	GO:0008283	cell population proliferation	Hipk2	IGI	MGI:MGI:1314872	Mouse	PMID:16537918
Biological Process	GO:0060026	convergent extension	hipk2	IMP	ZFIN:ZDB-MRPHLNO-141215-1	Zfish	PMID:25159144
Biological Process	GO:0060026	convergent extension	hipk2	IMP	ZFIN:ZDB-MRPHLNO-141229-3	Zfish	PMID:25159144
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	HIPK2	IDA		Human	PMID:14647468
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Hipk2	IGI	MGI:MGI:98834	Mouse	PMID:16537918
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Hipk2	IGI	MGI:MGI:1314872	Mouse	PMID:16537918
Biological Process	GO:0061072	iris morphogenesis	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0060235	lens induction in camera-type eye	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	HIPK2	IMP		Human	PMID:12874272
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	HIPK2	IMP		Human	PMID:21628596
Biological Process	GO:0051402	neuron apoptotic process	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989
Biological Process	GO:0030182	neuron differentiation	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0018105	peptidyl-serine phosphorylation	HIPK2	IDA		Human	PMID:33591310
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Hipk2	IDA		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Hipk2	IDA		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0045766	positive regulation of angiogenesis	HIPK2	IDA		Human	PMID:19046997
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hipk2	IGI	MGI:MGI:1314872	Mouse	PMID:16537918
Biological Process	GO:0043388	positive regulation of DNA binding	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Hipk2	IDA		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HIPK2	IMP		Human	PMID:14647468
Biological Process	GO:0046330	positive regulation of JNK cascade	HIPK2	IMP		Human	PMID:14678985
Biological Process	GO:0032092	positive regulation of protein binding	Hipk2	IDA		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Hipk2	IGI	MGI:MGI:98384	Mouse	PMID:20360400
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hipk2	IMP		Mouse	MGI:MGI:5306308\|PMID:16407227
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hipk2	IGI	MGI:MGI:108051	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hipk2	IGI	MGI:MGI:1201674	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hipk2	IGI	MGI:MGI:98727	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hipk2	IGI	MGI:MGI:894293	Mouse	PMID:17159989
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	HIPK2	IMP		Human	PMID:14678985
Biological Process	GO:0006468	protein phosphorylation	HIPK2	IDA		Human	PMID:19448668
Biological Process	GO:0006468	protein phosphorylation	Hipk2	IDA		Mouse	MGI:MGI:1303245\|PMID:9748262
Biological Process	GO:0006468	protein phosphorylation	Hipk2	IGI	MGI:MGI:98384	Mouse	PMID:20360400
Biological Process	GO:0045634	regulation of melanocyte differentiation	hipk2	IMP	ZFIN:ZDB-MRPHLNO-110331-3	Zfish	PMID:21199918
Biological Process	GO:0010842	retina layer formation	Hipk2	IMP		Mouse	MGI:MGI:4818711\|PMID:20579985
Biological Process	GO:0060395	SMAD protein signal transduction	HIPK2	IDA		Human	PMID:12874272
Biological Process	GO:0007224	smoothened signaling pathway	Hipk2	IGI	MGI:MGI:1314872	Mouse	PMID:16537918
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989
Biological Process	GO:0050882	voluntary musculoskeletal movement	Hipk2	IMP	MGI:MGI:3487301	Mouse	PMID:17159989

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.