Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HK2
- Mouse genes Hk2
- Rat genes Hk2
- Zfish genes hk2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Hk2	IDA		Rat	PMID:3900069\|RGD:2302672
Molecular Function	GO:0005524	ATP binding	Hk2	IDA		Rat	PMID:6603359\|RGD:2302671
Molecular Function	GO:0008865	fructokinase activity	Hk2	IDA		Rat	PMID:5871820\|RGD:14695073
Molecular Function	GO:0004340	glucokinase activity	HK2	IDA		Human	PMID:29298880
Molecular Function	GO:0004340	glucokinase activity	Hk2	IDA		Rat	PMID:5871820\|RGD:14695073
Molecular Function	GO:0005536	glucose binding	Hk2	IDA		Rat	PMID:3900069\|RGD:2302672
Molecular Function	GO:0005536	glucose binding	Hk2	IDA		Rat	PMID:6603359\|RGD:2302671
Molecular Function	GO:0005536	glucose binding	Hk2	IDA		Rat	PMID:8619630\|RGD:2302673
Molecular Function	GO:0004396	hexokinase activity	HK2	IDA		Human	PMID:26985301
Molecular Function	GO:0004396	hexokinase activity	Hk2	IDA		Mouse	PMID:18165236
Molecular Function	GO:0004396	hexokinase activity	Hk2	IMP	MGI:MGI:3624862	Mouse	PMID:10428828
Molecular Function	GO:0004396	hexokinase activity	Hk2	IDA		Rat	PMID:15138155\|RGD:1582633
Molecular Function	GO:0004396	hexokinase activity	Hk2	IDA		Rat	PMID:3900069\|RGD:2302672
Molecular Function	GO:0004396	hexokinase activity	Hk2	IDA		Rat	PMID:6603359\|RGD:2302671
Molecular Function	GO:0004396	hexokinase activity	Hk2	IDA		Rat	PMID:8619630\|RGD:2302673
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:Q9UMX0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:Q9NQ88	Human	PMID:23185017
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:P43365	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HK2	IPI	UniProtKB:P05480	Human	PMID:28054552
Cellular Component	GO:0005813	centrosome	HK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	HK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Hk2	IDA		Rat	PMID:29676955\|RGD:13703029
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	HK2	HDA		Human	PMID:19946888
Cellular Component	GO:0005741	mitochondrial outer membrane	HK2	IDA		Human	PMID:18350175
Cellular Component	GO:0005739	mitochondrion	HK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Hk2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Hk2	IDA		Rat	PMID:21410437\|RGD:7349317
Cellular Component	GO:0005886	plasma membrane	Hk2	IDA		Rat	PMID:29676955\|RGD:13703029
Cellular Component	GO:0016529	sarcoplasmic reticulum	Hk2	IDA		Rat	PMID:29676955\|RGD:13703029
Biological Process	GO:0008637	apoptotic mitochondrial changes	HK2	IDA		Human	PMID:18350175
Biological Process	GO:0008637	apoptotic mitochondrial changes	Hk2	IGI	MGI:MGI:1353495	Mouse	PMID:18350175
Biological Process	GO:0008637	apoptotic mitochondrial changes	Hk2	IGI	MGI:MGI:2145814	Mouse	PMID:18350175
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk2	IMP	MGI:MGI:3624862	Mouse	PMID:10428828
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk2	IDA		Rat	PMID:3900069\|RGD:2302672
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk2	IDA		Rat	PMID:6603359\|RGD:2302671
Biological Process	GO:0046835	carbohydrate phosphorylation	Hk2	IDA		Rat	PMID:8619630\|RGD:2302673
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Hk2	IEP		Mouse	PMID:20439489
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	HK2	IMP		Human	PMID:23962723
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Hk2	IDA		Rat	PMID:5871820\|RGD:14695073
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	HK2	IDA		Human	PMID:29298880
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Hk2	IDA		Rat	PMID:5871820\|RGD:14695073
Biological Process	GO:0006006	glucose metabolic process	Hk2	IMP	MGI:MGI:3624862	Mouse	PMID:10428828
Biological Process	GO:0007595	lactation	Hk2	IEP		Rat	PMID:10562464\|RGD:1624366
Biological Process	GO:0072656	maintenance of protein location in mitochondrion	HK2	IMP		Human	PMID:23962723
Biological Process	GO:0035795	negative regulation of mitochondrial membrane permeability	Hk2	IMP		Mouse	MGI:MGI:5619449\|PMID:22517678
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Hk2	IMP		Mouse	MGI:MGI:5619449\|PMID:22517678
Biological Process	GO:0045766	positive regulation of angiogenesis	HK2	IMP		Human	PMID:25801897
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	HK2	IMP		Human	PMID:23962723
Biological Process	GO:0046324	regulation of glucose import	Hk2	IMP	MGI:MGI:3624862	Mouse	PMID:17639019
Biological Process	GO:0001666	response to hypoxia	Hk2	IEP		Rat	PMID:29676955\|RGD:13703029
Biological Process	GO:0002931	response to ischemia	Hk2	IDA		Rat	PMID:21410437\|RGD:7349317

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.