Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMBS
  • Mouse genes Hmbs
  • Rat genes Hmbs
  • Zfish genes hmbsa,hmbsb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmbs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043176	amine binding	Hmbs	IPI	CHEBI:17381	Rat	PMID:9344466|RGD:2301695
Molecular Function	GO:0031406	carboxylic acid binding	Hmbs	IPI	CHEBI:17381	Rat	PMID:9344466|RGD:2301695
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	HMBS	IDA		Human	PMID:18004775
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	HMBS	IDA		Human	PMID:18936296
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:12127573|RGD:2301691
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:1386052|RGD:25440496
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IMP		Rat	PMID:18760440|RGD:2301858
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:3179323|RGD:2301707
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:3702597|RGD:4144820
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:3963818|RGD:4144803
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:593266|RGD:26884337
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:6712591|RGD:2301704
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:9344466|RGD:2301695
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:971328|RGD:25394583
Molecular Function	GO:0004418	hydroxymethylbilane synthase activity	Hmbs	IDA		Rat	PMID:994723|RGD:25440497
Molecular Function	GO:0005515	protein binding	HMBS	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMBS	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hmbs	IPI	RGD:1617568	Rat	PMID:12917623|RGD:2301689
Molecular Function	GO:0004852	uroporphyrinogen-III synthase activity	Hmbs	IDA		Rat	PMID:6466301|RGD:2303402
Cellular Component	GO:0030424	axon	Hmbs	IDA		Rat	PMID:11202056|RGD:4144783
Cellular Component	GO:0000793	condensed chromosome	Hmbs	IDA		Rat	PMID:12917623|RGD:2301689
Cellular Component	GO:0005737	cytoplasm	Hmbs	IDA		Rat	PMID:12917623|RGD:2301689
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:3702597|RGD:4144820
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:3963818|RGD:4144803
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:593266|RGD:26884337
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:6694518|RGD:25330343
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:6893114|RGD:26923963
Cellular Component	GO:0005829	cytosol	Hmbs	IDA		Rat	PMID:994723|RGD:25440497
Cellular Component	GO:0005634	nucleus	Hmbs	IDA		Rat	PMID:11953837|RGD:2301692
Cellular Component	GO:0005634	nucleus	Hmbs	IDA		Rat	PMID:12917623|RGD:2301689
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Hmbs	IDA		Rat	PMID:11202056|RGD:4144783
Biological Process	GO:0031100	animal organ regeneration	Hmbs	IEP		Rat	PMID:2886336|RGD:4144800
Biological Process	GO:0048708	astrocyte differentiation	Hmbs	IEP		Rat	PMID:12917623|RGD:2301689
Biological Process	GO:0071418	cellular response to amine stimulus	Hmbs	IEP		Rat	PMID:10416273|RGD:2303399
Biological Process	GO:0071236	cellular response to antibiotic	Hmbs	IEP		Rat	PMID:19688726|RGD:4144778
Biological Process	GO:0071243	cellular response to arsenic-containing substance	Hmbs	IEP		Rat	PMID:10416273|RGD:2303399
Biological Process	GO:0071345	cellular response to cytokine stimulus	Hmbs	IEP		Rat	PMID:4019471|RGD:4144804
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Hmbs	IEP		Rat	PMID:7917467|RGD:4144799
Biological Process	GO:0071284	cellular response to lead ion	Hmbs	IEP		Rat	PMID:16566714|RGD:4144781
Biological Process	GO:0006783	heme biosynthetic process	HMBS	IDA		Human	PMID:18936296
Biological Process	GO:0001889	liver development	Hmbs	IDA		Rat	PMID:971328|RGD:25394583
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:11202056|RGD:4144783
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:11786116|RGD:26923962
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:1781034|RGD:25440495
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:3179323|RGD:2301707
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:3702597|RGD:4144820
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:3963818|RGD:4144803
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:6694518|RGD:25330343
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:6732900|RGD:25394584
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:6893114|RGD:26923963
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:971328|RGD:25394583
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Hmbs	IDA		Rat	PMID:994723|RGD:25440497
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:11202056|RGD:4144783
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:11786116|RGD:26923962
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:1781034|RGD:25440495
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:3179323|RGD:2301707
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:3702597|RGD:4144820
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:3963818|RGD:4144803
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:593266|RGD:26884337
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:6732900|RGD:25394584
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:6893114|RGD:26923963
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:971328|RGD:25394583
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Hmbs	IDA		Rat	PMID:994723|RGD:25440497
Biological Process	GO:0043200	response to amino acid	Hmbs	IEP		Rat	PMID:8295845|RGD:4144812
Biological Process	GO:0009743	response to carbohydrate	Hmbs	IEP		Rat	PMID:17285311|RGD:1600699
Biological Process	GO:0032025	response to cobalt ion	Hmbs	IEP		Rat	PMID:6688350|RGD:4144808
Biological Process	GO:0032355	response to estradiol	Hmbs	IEP		Rat	PMID:10416826|RGD:4144786
Biological Process	GO:0009725	response to hormone	Hmbs	IEP		Rat	PMID:9468112|RGD:4144792
Biological Process	GO:0001666	response to hypoxia	Hmbs	IEP		Rat	PMID:3697363|RGD:4144802
Biological Process	GO:0010288	response to lead ion	Hmbs	IEP		Rat	PMID:16566714|RGD:4144781
Biological Process	GO:0010038	response to metal ion	Hmbs	IEP		Rat	PMID:4040350|RGD:4144805
Biological Process	GO:0051597	response to methylmercury	Hmbs	IEP		Rat	PMID:3327437|RGD:4145123
Biological Process	GO:0031667	response to nutrient levels	Hmbs	IEP		Rat	PMID:8000239|RGD:4144797
Biological Process	GO:0014070	response to organic cyclic compound	Hmbs	IEP		Rat	PMID:3580703|RGD:4144801
Biological Process	GO:0033273	response to vitamin	Hmbs	IEP		Rat	PMID:9559098|RGD:4144791
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmbs	IEP		Rat	PMID:10571258|RGD:4144785
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmbs	IDA		Rat	PMID:6893114|RGD:26923963
Biological Process	GO:0010043	response to zinc ion	Hmbs	IEP		Rat	PMID:8582750|RGD:4144793
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	Hmbs	IDA		Rat	PMID:12127573|RGD:2301691
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	Hmbs	IMP		Rat	PMID:18760440|RGD:2301858
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	Hmbs	IDA		Rat	PMID:6712591|RGD:2301704
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	Hmbs	IDA		Rat	PMID:9344466|RGD:2301695

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern