Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGA1
  • Mouse genes Hmga1
  • Rat genes Hmga1,RGD1564836
  • Zfish genes hmga1a,hmga1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmga1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	HMGA1	IDA		Human	PMID:9253416
Molecular Function	GO:0003677	DNA binding	HMGA1	IDA		Human	PMID:11069991
Molecular Function	GO:0003677	DNA binding	HMGA1	IDA		Human	PMID:15213251
Molecular Function	GO:0003677	DNA binding	HMGA1	EXP		Human	PMID:22615915
Molecular Function	GO:0003677	DNA binding	HMGA1	EXP		Human	PMID:9253416
Molecular Function	GO:0008301	DNA binding, bending	HMGA1	EXP		Human	PMID:22615915
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hmga1	IDA		Mouse	PMID:19223528
Molecular Function	GO:0019899	enzyme binding	HMGA1	IPI	UniProtKB:Q96LA8	Human	PMID:16157300
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA1	IDA		Human	PMID:9253416
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0060090	molecular adaptor activity	HMGA1	IDA		Human	PMID:11069991
Molecular Function	GO:0140677	molecular function activator activity	HMGA1	IMP		Human	PMID:21087998
Molecular Function	GO:0030374	nuclear receptor coactivator activity	HMGA1	IMP		Human	PMID:10428834
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	HMGA1	IDA		Human	PMID:10428834
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	HMGA1	IDA		Human	PMID:10428834
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	HMGA1	IDA		Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:P19838	Human	PMID:10400641
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:O75798	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:P05412	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:P13631	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:P19793	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:P37231	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:Q92793	Human	PMID:10428834
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:Q9Y5N6	Human	PMID:18234858
Molecular Function	GO:0005515	protein binding	HMGA1	IPI	UniProtKB:Q92793	Human	PMID:9809067
Molecular Function	GO:0003723	RNA binding	HMGA1	IPI	RNAcentral:URS0000734D8F_9606	Human	PMID:21087998
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0003713	transcription coactivator activity	HMGA1	IMP		Human	PMID:10428834
Molecular Function	GO:0003713	transcription coactivator activity	HMGA1	EXP		Human	PMID:9253416
Molecular Function	GO:0003713	transcription coactivator activity	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0001221	transcription coregulator binding	HMGA1	IDA		Human	PMID:10428834
Cellular Component	GO:0005925	focal adhesion	HMGA1	HDA		Human	PMID:21423176
Cellular Component	GO:0001673	male germ cell nucleus	Hmga1	IDA		Mouse	PMID:12032866
Cellular Component	GO:0005634	nucleus	HMGA1	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	HMGA1	IDA		Human	PMID:16901784
Cellular Component	GO:0005634	nucleus	Hmga1	IDA		Mouse	PMID:12032866
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	HMGA1	IDA		Human	PMID:16901784
Biological Process	GO:0008285	negative regulation of cell population proliferation	HMGA1	IMP		Human	PMID:16901784
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HMGA1	IMP		Human	PMID:16901784
Biological Process	GO:0090402	oncogene-induced cell senescence	HMGA1	IDA		Human	PMID:16901784
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA1	IMP		Human	PMID:10428834
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hmga1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0043484	regulation of RNA splicing	hmga1a	IMP	ZFIN:ZDB-MRPHLNO-141211-4	Zfish	PMID:25814654
Biological Process	GO:0007283	spermatogenesis	Hmga1	IMP	MGI:MGI:2673322	Mouse	PMID:12874803

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern