Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGA2
  • Mouse genes Hmga2
  • Rat genes Hmga2
  • Zfish genes hmga2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmga2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	HMGA2	IDA		Human	PMID:19465398
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	HMGA2	IMP		Human	PMID:14645522
Molecular Function	GO:0035497	cAMP response element binding	HMGA2	IDA		Human	PMID:14645522
Molecular Function	GO:0008301	DNA binding, bending	HMGA2	IMP		Human	PMID:14627817
Molecular Function	GO:0008301	DNA binding, bending	HMGA2	IDA		Human	PMID:20108983
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	HMGA2	IDA		Human	PMID:19465398
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hmga2	IDA		Mouse	PMID:19223528
Molecular Function	GO:0019899	enzyme binding	Hmga2	IPI	RGD:1332134	Rat	PMID:11390395|RGD:1601592
Molecular Function	GO:0035501	MH1 domain binding	HMGA2	IDA		Human	PMID:18832382
Molecular Function	GO:0035500	MH2 domain binding	HMGA2	IDA		Human	PMID:18832382
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IDA		Human	PMID:14627817
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IDA		Human	PMID:17078040
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IDA		Human	PMID:17426251
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IMP		Human	PMID:18832382
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IDA		Human	PMID:20108983
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	HMGA2	IDA		Human	PMID:21533145
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	Hmga2	IDA		Mouse	PMID:16109425
Molecular Function	GO:0003676	nucleic acid binding	HMGA2	EXP		Human	PMID:29262356
Molecular Function	GO:0031492	nucleosomal DNA binding	HMGA2	IDA		Human	PMID:17078040
Molecular Function	GO:0005515	protein binding	HMGA2	IPI	UniProtKB:Q96LA8	Human	PMID:16293633
Molecular Function	GO:0005515	protein binding	HMGA2	IPI	UniProtKB:P52292	Human	PMID:17324944
Molecular Function	GO:0005515	protein binding	HMGA2	IPI	UniProtKB:P27695	Human	PMID:19465398
Molecular Function	GO:0005515	protein binding	HMGA2	IPI	UniProtKB:Q01196	Human	PMID:29391048
Molecular Function	GO:0005515	protein binding	Hmga2	IPI	UniProtKB:P06400	Mouse	MGI:MGI:3639399|PMID:16766265
Molecular Function	GO:0005515	protein binding	Hmga2	IPI	PR:O35942	Mouse	PMID:14668482
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HMGA2	IPI	UniProtKB:Q66K89	Human	PMID:14645522
Molecular Function	GO:0046332	SMAD binding	HMGA2	IPI	UniProtKB:P84022	Human	PMID:18832382
Molecular Function	GO:0046332	SMAD binding	HMGA2	IPI	UniProtKB:Q13485	Human	PMID:18832382
Molecular Function	GO:0046332	SMAD binding	HMGA2	IPI	UniProtKB:Q15796	Human	PMID:18832382
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HMGA2	IDA		Human	PMID:17426251
Molecular Function	GO:0003714	transcription corepressor activity	HMGA2	IDA		Human	PMID:14627817
Cellular Component	GO:0001673	male germ cell nucleus	Hmga2	IDA		Mouse	PMID:14668482
Cellular Component	GO:0001673	male germ cell nucleus	Hmga2	IDA		Mouse	PMID:12032866
Cellular Component	GO:0000228	nuclear chromosome	Hmga2	IDA		Mouse	PMID:11555636
Cellular Component	GO:0005634	nucleus	HMGA2	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	HMGA2	IDA		Human	PMID:16901784
Cellular Component	GO:0005634	nucleus	HMGA2	IDA		Human	PMID:17078040
Cellular Component	GO:0005634	nucleus	HMGA2	IDA		Human	PMID:17324944
Cellular Component	GO:0005634	nucleus	Hmga2	IDA		Mouse	PMID:12032866
Cellular Component	GO:0005634	nucleus	Hmga2	IDA		Mouse	PMID:17305714
Cellular Component	GO:0005634	nucleus	Hmga2	IDA		Rat	PMID:11390395|RGD:1601592
Cellular Component	GO:0032993	protein-DNA complex	HMGA2	IDA		Human	PMID:19465398
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	HMGA2	IDA		Human	PMID:16901784
Cellular Component	GO:0071141	SMAD protein complex	HMGA2	IDA		Human	PMID:18832382
Biological Process	GO:0060612	adipose tissue development	Hmga2	IMP	MGI:MGI:1858044	Mouse	PMID:7958830
Biological Process	GO:0030325	adrenal gland development	Hmga2	IMP	MGI:MGI:1858044	Mouse	PMID:7958830
Biological Process	GO:0048708	astrocyte differentiation	Hmga2	IDA		Mouse	PMID:18640244
Biological Process	GO:0006284	base-excision repair	HMGA2	IDA		Human	PMID:19465398
Biological Process	GO:0008283	cell population proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199
Biological Process	GO:0021846	cell proliferation in forebrain	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199
Biological Process	GO:0002062	chondrocyte differentiation	HMGA2	IDA		Human	PMID:21484705
Biological Process	GO:0035988	chondrocyte proliferation	HMGA2	IDA		Human	PMID:21484705
Biological Process	GO:0035987	endodermal cell differentiation	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0001837	epithelial to mesenchymal transition	HMGA2	IMP		Human	PMID:18832382
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Hmga2	IMP		Mouse	PMID:24661562
Biological Process	GO:0045444	fat cell differentiation	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0045444	fat cell differentiation	HMGA2	IMP		Human	PMID:7606786
Biological Process	GO:0060613	fat pad development	Hmga2	IGI	MGI:MGI:104663	Mouse	PMID:10742101
Biological Process	GO:0048144	fibroblast proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:7651535
Biological Process	GO:0031507	heterochromatin formation	HMGA2	IDA		Human	PMID:16901784
Biological Process	GO:0035556	intracellular signal transduction	HMGA2	IDA		Human	PMID:16061642
Biological Process	GO:0060428	lung epithelium development	Hmga2	IMP	MGI:MGI:1858043	Mouse	PMID:24661562
Biological Process	GO:0008584	male gonad development	Hmga2	IMP	MGI:MGI:1858044	Mouse	PMID:7958830
Biological Process	GO:0048762	mesenchymal cell differentiation	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0048762	mesenchymal cell differentiation	HMGA2	IMP		Human	PMID:7606786
Biological Process	GO:0048333	mesodermal cell differentiation	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0003131	mesodermal-endodermal cell signaling	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0043922	negative regulation by host of viral transcription	HMGA2	IDA		Human	PMID:17005673
Biological Process	GO:0043066	negative regulation of apoptotic process	HMGA2	IDA		Human	PMID:19465398
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Hmga2	IDA		Mouse	PMID:18640244
Biological Process	GO:2000773	negative regulation of cellular senescence	Hmga2	IMP		Mouse	MGI:MGI:5582375|PMID:23072816
Biological Process	GO:0043392	negative regulation of DNA binding	HMGA2	IDA		Human	PMID:14645522
Biological Process	GO:0043392	negative regulation of DNA binding	HMGA2	IMP		Human	PMID:19549901
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HMGA2	IMP		Human	PMID:16901784
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:18832382
Biological Process	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	HMGA2	IDA		Human	PMID:19549901
Biological Process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	Hmga2	IDA		Rat	PMID:11390395|RGD:1601592
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Hmga2	IDA		Rat	PMID:11390395|RGD:1601592
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	HMGA2	IDA		Human	PMID:17005673
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HMGA2	IDA		Human	PMID:14627817
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hmga2	IDA		Rat	PMID:11390395|RGD:1601592
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Hmga2	IMP		Mouse	PMID:24661562
Biological Process	GO:0090402	oncogene-induced cell senescence	HMGA2	IDA		Human	PMID:16901784
Biological Process	GO:0021983	pituitary gland development	Hmga2	IMP	MGI:MGI:1856426	Mouse	PMID:504232
Biological Process	GO:0045766	positive regulation of angiogenesis	Hmga2	IMP		Mouse	MGI:MGI:5582375|PMID:23072816
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	Hmga2	IMP		Mouse	MGI:MGI:5582375|PMID:23072816
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Hmga2	IMP		Rat	PMID:9311991|RGD:1601604
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:15225648
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:15755872
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:17005673
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:17324944
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IDA		Human	PMID:17426251
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	Hmga2	IMP	MGI:MGI:1858043	Mouse	PMID:24661562
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:7651535
Biological Process	GO:0010628	positive regulation of gene expression	HMGA2	IDA		Human	PMID:18832382
Biological Process	GO:0010628	positive regulation of gene expression	Hmga2	IMP		Mouse	MGI:MGI:3046602|PMID:15225648
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Hmga2	IMP	MGI:MGI:1856426	Mouse	PMID:5051369
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Hmga2	IMP	MGI:MGI:1858044	Mouse	PMID:7958830
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:7651535
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Hmga2	IMP	MGI:MGI:1856426	Mouse	PMID:14794889
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Hmga2	IMP	MGI:MGI:1856426	Mouse	MGI:MGI:61256
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	HMGA2	IDA		Human	PMID:19549901
Biological Process	GO:2000648	positive regulation of stem cell proliferation	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:2000648	positive regulation of stem cell proliferation	HMGA2	IDA		Human	PMID:21484705
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HMGA2	IDA		Human	PMID:14645522
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HMGA2	IDA		Human	PMID:18832382
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hmga2	IDA		Mouse	PMID:24661562
Biological Process	GO:0010564	regulation of cell cycle process	HMGA2	IDA		Human	PMID:14645522
Biological Process	GO:0010564	regulation of cell cycle process	Hmga2	IDA		Mouse	MGI:MGI:5284804|PMID:14645522
Biological Process	GO:0006355	regulation of DNA-templated transcription	HMGA2	IMP		Human	PMID:7606786
Biological Process	GO:0060123	regulation of growth hormone secretion	Hmga2	IMP	MGI:MGI:1856426	Mouse	PMID:504232
Biological Process	GO:0090276	regulation of peptide hormone secretion	Hmga2	IMP	MGI:MGI:1856426	Mouse	PMID:504232
Biological Process	GO:2000036	regulation of stem cell population maintenance	HMGA2	IMP		Human	PMID:17624332
Biological Process	GO:0009615	response to virus	HMGA2	IEP		Human	PMID:17005673
Biological Process	GO:0007165	signal transduction	Hmga2	IMP		Rat	PMID:11390395|RGD:1601592
Biological Process	GO:0035019	somatic stem cell population maintenance	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199
Biological Process	GO:0035019	somatic stem cell population maintenance	Hmga2	IGI	MGI:MGI:104738	Mouse	PMID:18957199
Biological Process	GO:0007283	spermatogenesis	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:12032866
Biological Process	GO:0048863	stem cell differentiation	HMGA2	IEP		Human	PMID:17078040
Biological Process	GO:0072089	stem cell proliferation	Hmga2	IMP	MGI:MGI:2386412	Mouse	PMID:18957199

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern