Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hmgb1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HMGB1
- Mouse genes Hmgb1
- Rat genes Hmgb1,LOC108349189
- Zfish genes hmgb1a,hmgb1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008097	5S rRNA binding	Hmgb1	IDA		Rat	PMID:18845125\|RGD:2316767
Molecular Function	GO:0003681	bent DNA binding	Hmgb1	IDA		Rat	PMID:10962007\|RGD:8554262
Molecular Function	GO:0019958	C-X-C chemokine binding	HMGB1	IDA		Human	PMID:22370717
Molecular Function	GO:0010858	calcium-dependent protein kinase regulator activity	Hmgb1	IDA		Mouse	PMID:7741753
Molecular Function	GO:0000402	crossed form four-way junction DNA binding	Hmgb1	IDA		Rat	PMID:10962007\|RGD:8554262
Molecular Function	GO:0005125	cytokine activity	Hmgb1	IDA		Mouse	PMID:7635200
Molecular Function	GO:0005125	cytokine activity	Hmgb1	IDA		Mouse	PMID:7741753
Molecular Function	GO:0005125	cytokine activity	Hmgb1	IDA		Rat	PMID:14744997\|RGD:8554726
Molecular Function	GO:0005125	cytokine activity	Hmgb1	IDA		Rat	PMID:15251426\|RGD:8553407
Molecular Function	GO:0003684	damaged DNA binding	HMGB1	IDA		Human	PMID:17803946
Molecular Function	GO:0008301	DNA binding, bending	HMGB1	IMP		Human	PMID:19223331
Molecular Function	GO:0008301	DNA binding, bending	Hmgb1	IDA		Rat	PMID:17964600\|RGD:2316774
Molecular Function	GO:0070182	DNA polymerase binding	HMGB1	IDA		Human	PMID:17803946
Molecular Function	GO:0140297	DNA-binding transcription factor binding	HMGB1	IPI	UniProtKB:P06400	Human	PMID:19223331
Molecular Function	GO:0003690	double-stranded DNA binding	Hmgb1	IDA		Mouse	MGI:MGI:4367121\|PMID:19890330
Molecular Function	GO:0003690	double-stranded DNA binding	Hmgb1	IDA		Rat	PMID:11024186\|RGD:2316830
Molecular Function	GO:0003725	double-stranded RNA binding	Hmgb1	IDA		Mouse	MGI:MGI:4367121\|PMID:19890330
Molecular Function	GO:0000400	four-way junction DNA binding	Hmgb1	IDA		Rat	PMID:1547772\|RGD:2316829
Molecular Function	GO:0051861	glycolipid binding	Hmgb1	IDA		Rat	PMID:11279268\|RGD:734534
Molecular Function	GO:0008201	heparin binding	Hmgb1	IDA		Rat	PMID:11279268\|RGD:734534
Molecular Function	GO:0005178	integrin binding	HMGB1	IDA		Human	PMID:20826760
Molecular Function	GO:0001530	lipopolysaccharide binding	HMGB1	IDA		Human	PMID:21660935
Molecular Function	GO:0016829	lyase activity	HMGB1	IDA		Human	PMID:17803946
Molecular Function	GO:0003676	nucleic acid binding	Hmgb1	EXP		Mouse	MGI:MGI:7310016\|PMID:15379539
Molecular Function	GO:0000401	open form four-way junction DNA binding	Hmgb1	IDA		Rat	PMID:10962007\|RGD:8554262
Molecular Function	GO:0042277	peptide binding	Hmgb1	IDA		Rat	PMID:11748221\|RGD:632908
Molecular Function	GO:0001786	phosphatidylserine binding	HMGB1	IDA		Human	PMID:18768881
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:O15350-1	Human	PMID:11748232
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:O15350-2	Human	PMID:11748232
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P43246	Human	PMID:15014079
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q01664	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q14457	Human	PMID:20819940
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P04637	Human	PMID:23063560
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P42858	Human	PMID:23303669
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q15109	Human	PMID:24474694
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P08729	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P09874	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P84103	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q00839	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q96B54	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q96T23	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P08729	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P84103	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q00839	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q96B54	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q96T23	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:O95273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P08729	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:Q96T23	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P0DTC3	Human	PMID:35239449
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P20226	Human	PMID:8006019
Molecular Function	GO:0005515	protein binding	HMGB1	IPI	UniProtKB:P04637	Human	PMID:9472015
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	UniProtKB:P24807	Mouse	MGI:MGI:5913663\|PMID:19264983
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	UniProtKB:Q01860	Mouse	MGI:MGI:5788399\|PMID:11099378
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	UniProtKB:Q8VIM0	Mouse	MGI:MGI:5437532\|PMID:22842346
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	UniProtKB:O88597	Mouse	MGI:MGI:5634889\|PMID:20819940
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	RGD:70502	Rat	PMID:14581561\|RGD:2316825
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	UniProtKB:Q9IW59	Rat	PMID:14581561\|RGD:2316825
Molecular Function	GO:0005515	protein binding	Hmgb1	IPI	RGD:733186	Rat	PMID:15597044\|RGD:2316799
Molecular Function	GO:0030295	protein kinase activator activity	Hmgb1	IDA		Mouse	PMID:7741753
Molecular Function	GO:0050786	RAGE receptor binding	Hmgb1	IMP		Rat	PMID:15644117\|RGD:2316796
Molecular Function	GO:0050786	RAGE receptor binding	Hmgb1	IPI	RGD:69258	Rat	PMID:22740883\|RGD:7245517
Molecular Function	GO:0050786	RAGE receptor binding	Hmgb1	IPI	UniProtKB:Q63495	Rat	PMID:7592757\|RGD:68739
Molecular Function	GO:0048018	receptor ligand activity	HMGB1	IDA		Human	PMID:17568691
Molecular Function	GO:0003723	RNA binding	HMGB1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	HMGB1	HDA		Human	PMID:22681889
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	HMGB1	IPI	UniProtKB:P25208	Human	PMID:19223331
Molecular Function	GO:0003697	single-stranded DNA binding	Hmgb1	IDA		Rat	PMID:11024186\|RGD:2316830
Molecular Function	GO:0003727	single-stranded RNA binding	Hmgb1	IDA		Mouse	MGI:MGI:4367121\|PMID:19890330
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HMGB1	IDA		Human	PMID:19158276
Molecular Function	GO:0003713	transcription coactivator activity	HMGB1	IDA		Human	PMID:19223331
Molecular Function	GO:0003714	transcription corepressor activity	HMGB1	IDA		Human	PMID:11748232
Cellular Component	GO:0035868	alphav-beta3 integrin-HMGB1 complex	HMGB1	IDA		Human	PMID:20826760
Cellular Component	GO:0009986	cell surface	HMGB1	IDA		Human	PMID:19841752
Cellular Component	GO:0000793	condensed chromosome	HMGB1	IDA		Human	PMID:12925773
Cellular Component	GO:0005737	cytoplasm	Hmgb1	IDA		Mouse	PMID:9767109
Cellular Component	GO:0005737	cytoplasm	Hmgb1	IDA		Mouse	PMID:12609598
Cellular Component	GO:0005737	cytoplasm	Hmgb1	IDA		Rat	PMID:20043889\|RGD:2316736
Cellular Component	GO:0005829	cytosol	Hmgb1	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0005769	early endosome	Hmgb1	IDA		Mouse	MGI:MGI:4367121\|PMID:19890330
Cellular Component	GO:0005783	endoplasmic reticulum	HMGB1	IDA		Human	PMID:35239449
Cellular Component	GO:0005615	extracellular space	HMGB1	IDA		Human	PMID:25595774
Cellular Component	GO:0005615	extracellular space	HMGB1	IDA		Human	PMID:19841752
Cellular Component	GO:0005615	extracellular space	Hmgb1	IDA		Mouse	MGI:MGI:6244743\|PMID:28096568
Cellular Component	GO:0005615	extracellular space	Hmgb1	IDA		Mouse	PMID:12609598
Cellular Component	GO:0005615	extracellular space	Hmgb1	IDA		Mouse	PMID:15140875
Cellular Component	GO:0005615	extracellular space	Hmgb1	IDA		Mouse	PMID:7635200
Cellular Component	GO:0005615	extracellular space	Hmgb1	IDA		Rat	PMID:20160670\|RGD:5684987
Cellular Component	GO:0045121	membrane raft	Hmgb1	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0043005	neuron projection	Hmgb1	IDA		Mouse	PMID:12609598
Cellular Component	GO:0005634	nucleus	HMGB1	IDA		Human	PMID:19223331
Cellular Component	GO:0005634	nucleus	HMGB1	IDA		Human	PMID:8339930
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Mouse	MGI:MGI:6244743\|PMID:28096568
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Mouse	PMID:14744997
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Mouse	PMID:9767109
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Mouse	PMID:12609598
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Rat	PMID:19944723\|RGD:2316741
Cellular Component	GO:0005634	nucleus	Hmgb1	IDA		Rat	PMID:20043889\|RGD:2316736
Cellular Component	GO:0005886	plasma membrane	hmgb1a	IDA		Zfish	PMID:21527633
Cellular Component	GO:0017053	transcription repressor complex	HMGB1	IDA		Human	PMID:19158276
Biological Process	GO:0031532	actin cytoskeleton reorganization	Hmgb1	IMP		Rat	PMID:11257120\|RGD:2316828
Biological Process	GO:0002218	activation of innate immune response	HMGB1	IDA		Human	PMID:24971542
Biological Process	GO:0043277	apoptotic cell clearance	HMGB1	IDA		Human	PMID:18768881
Biological Process	GO:0031103	axon regeneration	hmgb1a	IMP	ZFIN:ZDB-MRPHLNO-110705-1	Zfish	PMID:23996344
Biological Process	GO:0006284	base-excision repair	Hmgb1	IMP		Mouse	MGI:MGI:3722031\|PMID:17803946
Biological Process	GO:0000902	cell morphogenesis	Hmgb1	IMP		Rat	PMID:1885601\|RGD:728426
Biological Process	GO:0071347	cellular response to interleukin-1	Hmgb1	IEP		Rat	PMID:16354107\|RGD:2316792
Biological Process	GO:0098761	cellular response to interleukin-7	Hmgb1	IDA		Mouse	PMID:29581031
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Hmgb1	IDA		Mouse	MGI:MGI:6244743\|PMID:28096568
Biological Process	GO:0006935	chemotaxis	Hmgb1	IDA		Rat	PMID:19139725\|RGD:2316760
Biological Process	GO:0006325	chromatin organization	Hmgb1	IDA		Mouse	MGI:MGI:3807115\|PMID:18650382
Biological Process	GO:0007623	circadian rhythm	Hmgb1	IEP		Rat	PMID:17226794\|RGD:2316777
Biological Process	GO:0032392	DNA geometric change	Hmgb1	IDA		Rat	PMID:10962007\|RGD:8554262
Biological Process	GO:0035767	endothelial cell chemotaxis	Hmgb1	IDA		Mouse	MGI:MGI:3760906\|PMID:16365390
Biological Process	GO:0001935	endothelial cell proliferation	Hmgb1	IDA		Mouse	MGI:MGI:3760906\|PMID:16365390
Biological Process	GO:0001654	eye development	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0030900	forebrain development	hmgb1a	IMP	ZFIN:ZDB-MRPHLNO-110729-7	Zfish	PMID:21527633
Biological Process	GO:0005980	glycogen catabolic process	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0031507	heterochromatin formation	HMGB1	IGI	UniProtKB:P07305	Human	PMID:19158276
Biological Process	GO:0050930	induction of positive chemotaxis	Hmgb1	IDA		Rat	PMID:14744997\|RGD:8554726
Biological Process	GO:0006954	inflammatory response	HMGB1	IDA		Human	PMID:23146691
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	HMGB1	IEP		Human	PMID:19841752
Biological Process	GO:0030324	lung development	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0002281	macrophage activation involved in immune response	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0050831	male-specific defense response to bacterium	Hmgb1	IDA		Rat	PMID:16997939\|RGD:2316780
Biological Process	GO:0030099	myeloid cell differentiation	Hmgb1	IDA		Mouse	PMID:7741753
Biological Process	GO:0030099	myeloid cell differentiation	Hmgb1	IDA		Mouse	PMID:7635200
Biological Process	GO:0001773	myeloid dendritic cell activation	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Hmgb1	IDA		Mouse	PMID:7741753
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Hmgb1	IDA		Mouse	PMID:7635200
Biological Process	GO:0051450	myoblast proliferation	Hmgb1	IMP		Rat	PMID:16407300\|RGD:2316788
Biological Process	GO:2000426	negative regulation of apoptotic cell clearance	HMGB1	IDA		Human	PMID:20826760
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	HMGB1	IDA		Human	PMID:23148224
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	HMGB1	IDA		Human	PMID:22473704
Biological Process	GO:0008156	negative regulation of DNA replication	Hmgb1	IDA		Rat	PMID:18191612\|RGD:2316772
Biological Process	GO:0017055	negative regulation of RNA polymerase II transcription preinitiation complex assembly	HMGB1	IDA		Human	PMID:8006019
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HMGB1	IDA		Human	PMID:11748232
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HMGB1	IGI	UniProtKB:P07305	Human	PMID:19158276
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HMGB1	IMP		Human	PMID:19158276
Biological Process	GO:0032689	negative regulation of type II interferon production	HMGB1	IDA		Human	PMID:22473704
Biological Process	GO:0007399	nervous system development	Hmgb1	IMP		Rat	PMID:1885601\|RGD:728426
Biological Process	GO:0051402	neuron apoptotic process	Hmgb1	IMP		Rat	PMID:19944723\|RGD:2316741
Biological Process	GO:0031175	neuron projection development	Hmgb1	IGI	UniProtKB:Q63495	Rat	PMID:7592757\|RGD:68739
Biological Process	GO:0097350	neutrophil clearance	HMGB1	IDA		Human	PMID:18768881
Biological Process	GO:0002270	plasmacytoid dendritic cell activation	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	HMGB1	IMP		Human	PMID:15944249
Biological Process	GO:0043065	positive regulation of apoptotic process	HMGB1	IDA		Human	PMID:19800306
Biological Process	GO:0043065	positive regulation of apoptotic process	Hmgb1	IMP		Rat	PMID:16407300\|RGD:2316788
Biological Process	GO:0010508	positive regulation of autophagy	HMGB1	IMP		Human	PMID:20819940
Biological Process	GO:0010508	positive regulation of autophagy	Hmgb1	IMP		Mouse	MGI:MGI:5634889\|PMID:20819940
Biological Process	GO:0010508	positive regulation of autophagy	Hmgb1	IMP		Rat	PMID:23604926\|RGD:10402086
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	HMGB1	IMP		Human	PMID:28276476
Biological Process	GO:0030335	positive regulation of cell migration	Hmgb1	IDA		Rat	PMID:14744997\|RGD:8554726
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hmgb1	IDA		Rat	PMID:18929840\|RGD:2316764
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	HMGB1	IDA		Human	PMID:26961863
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	HMGB1	IDA		Human	PMID:19800306
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	HMGB1	IDA		Human	PMID:22370717
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	HMGB1	IMP		Human	PMID:15944249
Biological Process	GO:0043388	positive regulation of DNA binding	HMGB1	IDA		Human	PMID:11748232
Biological Process	GO:0043388	positive regulation of DNA binding	HMGB1	IDA		Human	PMID:19223331
Biological Process	GO:0051106	positive regulation of DNA ligation	Hmgb1	IDA		Rat	PMID:10866811\|RGD:10449519
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HMGB1	IDA		Human	PMID:22370717
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Hmgb1	IDA		Mouse	MGI:MGI:3760906\|PMID:16365390
Biological Process	GO:0045819	positive regulation of glycogen catabolic process	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0045089	positive regulation of innate immune response	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032728	positive regulation of interferon-beta production	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032732	positive regulation of interleukin-1 production	HMGB1	IDA		Human	PMID:12765338
Biological Process	GO:0032732	positive regulation of interleukin-1 production	Hmgb1	IDA		Rat	PMID:10952726\|RGD:10054071
Biological Process	GO:0032733	positive regulation of interleukin-10 production	HMGB1	IDA		Human	PMID:22473704
Biological Process	GO:0032735	positive regulation of interleukin-12 production	HMGB1	IMP		Human	PMID:15944249
Biological Process	GO:0032755	positive regulation of interleukin-6 production	HMGB1	IDA		Human	PMID:12765338
Biological Process	GO:0032755	positive regulation of interleukin-6 production	HMGB1	IDA		Human	PMID:26961863
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Hmgb1	IMP		Mouse	MGI:MGI:5913663\|PMID:19264983
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Hmgb1	IDA		Rat	PMID:10952726\|RGD:10054071
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Hmgb1	IMP		Rat	PMID:22514737\|RGD:10402175
Biological Process	GO:0032757	positive regulation of interleukin-8 production	HMGB1	IDA		Human	PMID:26961863
Biological Process	GO:0032757	positive regulation of interleukin-8 production	Hmgb1	IDA		Rat	PMID:10952726\|RGD:10054071
Biological Process	GO:0046330	positive regulation of JNK cascade	HMGB1	IDA		Human	PMID:12765338
Biological Process	GO:0071642	positive regulation of macrophage inflammatory protein 1 alpha production	Hmgb1	IDA		Rat	PMID:10952726\|RGD:10054071
Biological Process	GO:0043410	positive regulation of MAPK cascade	HMGB1	IDA		Human	PMID:12765338
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Hmgb1	IDA		Rat	PMID:14744997\|RGD:8554726
Biological Process	GO:0032425	positive regulation of mismatch repair	HMGB1	IDA		Human	PMID:15014079
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Hmgb1	IDA		Rat	PMID:14744997\|RGD:8554726
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	Hmgb1	IMP		Mouse	MGI:MGI:5913663\|PMID:19264983
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	HMGB1	IDA		Human	PMID:22370717
Biological Process	GO:0033034	positive regulation of myeloid cell apoptotic process	Hmgb1	IDA		Rat	PMID:18952078\|RGD:2316763
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	Hmgb1	IDA		Mouse	PMID:7635200
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	Hmgb1	IDA		Mouse	PMID:7741753
Biological Process	GO:1905455	positive regulation of myeloid progenitor cell differentiation	Hmgb1	IDA		Mouse	PMID:7635200
Biological Process	GO:1905455	positive regulation of myeloid progenitor cell differentiation	Hmgb1	IDA		Mouse	PMID:7741753
Biological Process	GO:0045663	positive regulation of myoblast differentiation	Hmgb1	IMP		Rat	PMID:15143181\|RGD:2316802
Biological Process	GO:0010976	positive regulation of neuron projection development	Hmgb1	IMP		Rat	PMID:11507219\|RGD:2316826
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Hmgb1	IDA		Mouse	MGI:MGI:5788395\|PMID:16267105
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Hmgb1	IDA		Mouse	PMID:7741753
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Hmgb1	IMP		Rat	PMID:11257120\|RGD:2316828
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Hmgb1	IDA		Mouse	MGI:MGI:3760906\|PMID:16365390
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	Hmgb1	IDA		Mouse	MGI:MGI:5788395\|PMID:16267105
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	Hmgb1	IDA		Mouse	MGI:MGI:5788395\|PMID:16267105
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HMGB1	IDA		Human	PMID:19223331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	HMGB1	IDA		Human	PMID:12765338
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Hmgb1	IMP		Mouse	MGI:MGI:5913663\|PMID:19264983
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Hmgb1	IMP		Mouse	MGI:MGI:4367121\|PMID:19890330
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Hmgb1	IDA		Rat	PMID:10952726\|RGD:10054071
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Hmgb1	IMP		Rat	PMID:22514737\|RGD:10402175
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	HMGB1	IMP		Human	PMID:28276476
Biological Process	GO:0046598	positive regulation of viral entry into host cell	HMGB1	IMP		Human	PMID:33147444
Biological Process	GO:0090303	positive regulation of wound healing	Hmgb1	IDA		Mouse	MGI:MGI:3760906\|PMID:16365390
Biological Process	GO:0065003	protein-containing complex assembly	Hmgb1	IDA		Rat	PMID:1547772\|RGD:2316829
Biological Process	GO:0031099	regeneration	hmgb1a	IMP	ZFIN:ZDB-MRPHLNO-110705-1	Zfish	PMID:23996344
Biological Process	GO:0050727	regulation of inflammatory response	Hmgb1	IDA		Rat	PMID:18824741\|RGD:2316769
Biological Process	GO:2000819	regulation of nucleotide-excision repair	Hmgb1	IMP		Mouse	MGI:MGI:3807115\|PMID:18650382
Biological Process	GO:0032072	regulation of restriction endodeoxyribonuclease activity	HMGB1	IDA		Human	PMID:17803946
Biological Process	GO:0002840	regulation of T cell mediated immune response to tumor cell	Hmgb1	IDA		Mouse	MGI:MGI:5470371\|PMID:23108142
Biological Process	GO:0002643	regulation of tolerance induction	HMGB1	IDA		Human	PMID:18631454
Biological Process	GO:0002643	regulation of tolerance induction	Hmgb1	IMP		Mouse	MGI:MGI:3803065\|PMID:18631454
Biological Process	GO:0009409	response to cold	hmgb1a	IDA		Zfish	PMID:18805806
Biological Process	GO:0051384	response to glucocorticoid	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0009749	response to glucose	Hmgb1	IEP		Rat	PMID:18596634\|RGD:2316770
Biological Process	GO:0009408	response to heat	Hmgb1	IEP		Rat	PMID:20160670\|RGD:5684987
Biological Process	GO:0032868	response to insulin	Hmgb1	IEP		Rat	PMID:15192048\|RGD:1625687
Biological Process	GO:0032496	response to lipopolysaccharide	Hmgb1	IEP		Rat	PMID:19959191\|RGD:2316737
Biological Process	GO:0034341	response to type II interferon	Hmgb1	IMP		Rat	PMID:18004227\|RGD:2316773
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgb1	IEP		Rat	PMID:16125245\|RGD:2316793
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgb1	IEP		Rat	PMID:29091898\|RGD:15090820
Biological Process	GO:0035711	T-helper 1 cell activation	HMGB1	IDA		Human	PMID:22473704
Biological Process	GO:0045063	T-helper 1 cell differentiation	HMGB1	IMP		Human	PMID:15944249
Biological Process	GO:0006366	transcription by RNA polymerase II	Hmgb1	IMP	MGI:MGI:3530901	Mouse	PMID:10391216
Biological Process	GO:0033151	V(D)J recombination	HMGB1	IDA		Human	PMID:9166431

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.