Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGB2
  • Mouse genes Hmgb2
  • Rat genes Hmgb2,Hmgb2-ps6,Hmgb2l1,RGD1561694
  • Zfish genes hmgb2a,hmgb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042056	chemoattractant activity	HMGB2	IDA		Human	PMID:19811285
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Hmgb2	IDA		Mouse	MGI:MGI:5490149|PMID:23495099
Molecular Function	GO:0003684	damaged DNA binding	HMGB2	IDA		Human	PMID:8226934
Molecular Function	GO:0003677	DNA binding	HMGB2	IMP		Human	PMID:11909973
Molecular Function	GO:0008301	DNA binding, bending	HMGB2	IDA		Human	PMID:11909973
Molecular Function	GO:0008301	DNA binding, bending	HMGB2	IDA		Human	PMID:8339930
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Hmgb2	IPI	UniProtKB:Q60707	Mouse	MGI:MGI:6710296|PMID:33795231
Molecular Function	GO:0003690	double-stranded DNA binding	Hmgb2	IDA		Mouse	MGI:MGI:4367121|PMID:19890330
Molecular Function	GO:0008289	lipid binding	Hmgb2	IDA		Rat	PMID:11279268|RGD:734534
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q01105	Human	PMID:11909973
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q96I87	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q96B54	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q9BRT3	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:P55347	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q8N668	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q96B54	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q9BRT3	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q9NZM5	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:P55347	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q99598	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q8N668	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q96B54	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q9BRT3	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:Q9NZM5	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	HMGB2	IPI	UniProtKB:P23497-3	Human	PMID:9636147
Molecular Function	GO:0005515	protein binding	Hmgb2	IPI	UniProtKB:P27782	Mouse	MGI:MGI:4361752|PMID:19805379
Molecular Function	GO:0019904	protein domain specific binding	Hmgb2	IPI	PR:Q00196	Mouse	PMID:7720710
Molecular Function	GO:0050786	RAGE receptor binding	HMGB2	IGI	UniProtKB:Q28173	Human	PMID:19811285
Molecular Function	GO:0003723	RNA binding	HMGB2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	HMGB2	HDA		Human	PMID:22681889
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HMGB2	IDA		Human	PMID:19965638
Molecular Function	GO:0003713	transcription coactivator activity	HMGB2	IDA		Human	PMID:19223331
Molecular Function	GO:0008134	transcription factor binding	Hmgb2	IDA		Mouse	MGI:MGI:5490149|PMID:23495099
Cellular Component	GO:0000785	chromatin	Hmgb2	IDA		Mouse	MGI:MGI:5490149|PMID:23495099
Cellular Component	GO:0000793	condensed chromosome	HMGB2	IDA		Human	PMID:12925773
Cellular Component	GO:0005737	cytoplasm	HMGB2	IDA		Human	PMID:11909973
Cellular Component	GO:0005737	cytoplasm	Hmgb2	IDA		Mouse	MGI:MGI:5640906|PMID:25306442
Cellular Component	GO:0005615	extracellular space	HMGB2	IDA		Human	PMID:19811285
Cellular Component	GO:0005615	extracellular space	Hmgb2	IDA		Mouse	MGI:MGI:5640906|PMID:25306442
Cellular Component	GO:0005730	nucleolus	HMGB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HMGB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HMGB2	IDA		Human	PMID:11909973
Cellular Component	GO:0005634	nucleus	HMGB2	IDA		Human	PMID:8339930
Cellular Component	GO:0005634	nucleus	Hmgb2	IDA		Mouse	MGI:MGI:5640906|PMID:25306442
Cellular Component	GO:0005634	nucleus	Hmgb2	IDA		Rat	PMID:8432381|RGD:2316096
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HMGB2	IDA		Human	PMID:11909973
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HMGB2	IDA		Human	PMID:9010268
Cellular Component	GO:0032991	protein-containing complex	HMGB2	IDA		Human	PMID:11909973
Biological Process	GO:0031100	animal organ regeneration	Hmgb2	IEP		Rat	PMID:457681|RGD:2316100
Biological Process	GO:0060326	cell chemotaxis	HMGB2	IDA		Human	PMID:19811285
Biological Process	GO:0071222	cellular response to lipopolysaccharide	HMGB2	IEP		Human	PMID:19811285
Biological Process	GO:0050829	defense response to Gram-negative bacterium	HMGB2	IDA		Human	PMID:23877675
Biological Process	GO:0050830	defense response to Gram-positive bacterium	HMGB2	IDA		Human	PMID:23877675
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:19139395
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Hmgb2	IMP		Mouse	MGI:MGI:5640906|PMID:25306442
Biological Process	GO:0008584	male gonad development	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:11262228
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HMGB2	IDA		Human	PMID:9636147
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:19139395
Biological Process	GO:0010629	negative regulation of gene expression	Hmgb2	IDA		Mouse	MGI:MGI:5490149|PMID:23495099
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HMGB2	IDA		Human	PMID:11748232
Biological Process	GO:0007399	nervous system development	Hmgb2	IDA		Rat	PMID:11279268|RGD:734534
Biological Process	GO:0043388	positive regulation of DNA binding	HMGB2	IDA		Human	PMID:19965638
Biological Process	GO:0043388	positive regulation of DNA binding	Hmgb2	IDA		Mouse	PMID:7720710
Biological Process	GO:0051054	positive regulation of DNA metabolic process	Hmgb2	IMP		Rat	PMID:8432381|RGD:2316096
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HMGB2	IDA		Human	PMID:19965638
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hmgb2	IMP		Rat	PMID:1525238|RGD:2316097
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	HMGB2	IDA		Human	PMID:19811285
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	HMGB2	IMP		Human	PMID:19965638
Biological Process	GO:0010628	positive regulation of gene expression	Hmgb2	IDA		Mouse	MGI:MGI:5490149|PMID:23495099
Biological Process	GO:0045089	positive regulation of innate immune response	Hmgb2	IMP		Mouse	MGI:MGI:4367121|PMID:19890330
Biological Process	GO:0032728	positive regulation of interferon-beta production	Hmgb2	IMP		Mouse	MGI:MGI:4367121|PMID:19890330
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	HMGB2	IMP		Human	PMID:19965638
Biological Process	GO:0032075	positive regulation of nuclease activity	HMGB2	IDA		Human	PMID:978439
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HMGB2	IDA		Human	PMID:19223331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HMGB2	IDA		Human	PMID:19965638
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:11262228
Biological Process	GO:0050767	regulation of neurogenesis	Hmgb2	IMP		Mouse	MGI:MGI:5568800|PMID:24391977
Biological Process	GO:0072091	regulation of stem cell proliferation	Hmgb2	IMP		Mouse	MGI:MGI:5568800|PMID:24391977
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	HMGB2	IDA		Human	PMID:7797075
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Hmgb2	IDA		Mouse	PMID:7720710
Biological Process	GO:0032496	response to lipopolysaccharide	Hmgb2	IMP		Mouse	MGI:MGI:5640906|PMID:25306442
Biological Process	GO:0048545	response to steroid hormone	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:11262228
Biological Process	GO:0007289	spermatid nucleus differentiation	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:16765935
Biological Process	GO:0007283	spermatogenesis	Hmgb2	IMP	MGI:MGI:2387671	Mouse	PMID:11262228

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern