Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGCL
  • Mouse genes Hmgcl
  • Rat genes Hmgcl
  • Zfish genes hmgcl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgcl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031406	carboxylic acid binding	Hmgcl	IPI	CHEBI:13705	Rat	PMID:2573547|RGD:1599519
Molecular Function	GO:0000062	fatty-acyl-CoA binding	Hmgcl	IPI	CHEBI:15351	Rat	PMID:2573547|RGD:1599519
Molecular Function	GO:0000062	fatty-acyl-CoA binding	Hmgcl	IPI	CHEBI:15467	Rat	PMID:2573547|RGD:1599519
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:12464283
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:22847177
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:22865860
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:8027038
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:8670134
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:9200711
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	HMGCL	IDA		Human	PMID:9869651
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	Hmgcl	IDA		Rat	PMID:2573547|RGD:1599519
Molecular Function	GO:0000287	magnesium ion binding	HMGCL	IDA		Human	PMID:9200711
Molecular Function	GO:0030145	manganese ion binding	HMGCL	IDA		Human	PMID:9200711
Molecular Function	GO:0046872	metal ion binding	HMGCL	IDA		Human	PMID:16330550
Molecular Function	GO:0005198	structural molecule activity	HMGCL	IDA		Human	PMID:12464283
Cellular Component	GO:0005743	mitochondrial inner membrane	Hmgcl	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	HMGCL	IDA		Human	PMID:9869651
Cellular Component	GO:0005739	mitochondrion	Hmgcl	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hmgcl	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Hmgcl	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Hmgcl	IDA		Rat	PMID:2573547|RGD:1599519
Cellular Component	GO:0005777	peroxisome	HMGCL	IDA		Human	PMID:12464283
Cellular Component	GO:0005777	peroxisome	HMGCL	IDA		Human	PMID:9869651
Cellular Component	GO:0032991	protein-containing complex	HMGCL	IDA		Human	PMID:12464283
Biological Process	GO:0006637	acyl-CoA metabolic process	Hmgcl	IDA		Rat	PMID:2573547|RGD:1599519
Biological Process	GO:0009790	embryo development	Hmgcl	IMP	MGI:MGI:3640351	Mouse	PMID:9817922
Biological Process	GO:0046951	ketone body biosynthetic process	HMGCL	IDA		Human	PMID:22847177
Biological Process	GO:0046951	ketone body biosynthetic process	HMGCL	IDA		Human	PMID:22865860
Biological Process	GO:0046951	ketone body biosynthetic process	HMGCL	IDA		Human	PMID:9200711
Biological Process	GO:0046951	ketone body biosynthetic process	Hmgcl	IDA		Rat	PMID:2573547|RGD:1599519
Biological Process	GO:0006629	lipid metabolic process	HMGCL	IDA		Human	PMID:8027038
Biological Process	GO:0001889	liver development	Hmgcl	IEP		Rat	PMID:13990|RGD:2326149
Biological Process	GO:0007005	mitochondrion organization	Hmgcl	IMP	MGI:MGI:3640351	Mouse	PMID:9817922
Biological Process	GO:0070542	response to fatty acid	Hmgcl	IEP		Rat	PMID:10419135|RGD:2326127
Biological Process	GO:0007584	response to nutrient	Hmgcl	IEP		Rat	PMID:5667251|RGD:2326171
Biological Process	GO:0042594	response to starvation	Hmgcl	IEP		Rat	PMID:5667251|RGD:2326171

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern