Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGCS1
  • Mouse genes Hmgcs1
  • Rat genes Hmgcs1
  • Zfish genes hmgcs1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgcs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Hmgcs1	IDA		Rat	PMID:8094614|RGD:2326140
Molecular Function	GO:0016853	isomerase activity	Hmgcs1	IDA		Rat	PMID:17764185|RGD:2326141
Molecular Function	GO:0043177	organic acid binding	Hmgcs1	IDA		Rat	PMID:8094614|RGD:2326140
Molecular Function	GO:0042803	protein homodimerization activity	HMGCS1	IDA		Human	PMID:20346956
Molecular Function	GO:0036094	small molecule binding	Hmgcs1	IDA		Rat	PMID:14984735|RGD:2316844
Cellular Component	GO:0005829	cytosol	Hmgcs1	IDA		Rat	PMID:14984735|RGD:2316844
Biological Process	GO:0007420	brain development	Hmgcs1	IEP		Rat	PMID:6133227|RGD:2326147
Biological Process	GO:0071397	cellular response to cholesterol	Hmgcs1	IEP		Rat	PMID:18303831|RGD:2326114
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Hmgcs1	IEP		Rat	PMID:19196834|RGD:2326113
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Hmgcs1	IDA		Rat	PMID:16260|RGD:2302235
Biological Process	GO:0071407	cellular response to organic cyclic compound	Hmgcs1	IEP		Rat	PMID:9409294|RGD:2326162
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hmgcs1	IMP	ZFIN:ZDB-GENO-210819-8	Zfish	PMID:33197123
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hmgcs1	IMP	ZFIN:ZDB-GENO-170915-2	Zfish	PMID:28686747
Biological Process	GO:0048821	erythrocyte development	hmgcs1	IMP	ZFIN:ZDB-GENO-170915-2	Zfish	PMID:30987969
Biological Process	GO:0001889	liver development	Hmgcs1	IEP		Rat	PMID:5166591|RGD:2326169
Biological Process	GO:0008584	male gonad development	Hmgcs1	IEP		Rat	PMID:11792726|RGD:2326159
Biological Process	GO:0014033	neural crest cell differentiation	hmgcs1	IMP	ZFIN:ZDB-GENO-170915-2	Zfish	PMID:28686747
Biological Process	GO:0014003	oligodendrocyte development	hmgcs1	IMP	ZFIN:ZDB-GENO-140728-3	Zfish	PMID:24573296
Biological Process	GO:0070723	response to cholesterol	Hmgcs1	IEP		Rat	PMID:2903839|RGD:2326164
Biological Process	GO:0034698	response to gonadotropin	Hmgcs1	IEP		Rat	PMID:15459111|RGD:2326154
Biological Process	GO:0009725	response to hormone	Hmgcs1	IEP		Rat	PMID:8093833|RGD:2326142
Biological Process	GO:0009645	response to low light intensity stimulus	Hmgcs1	IEP		Rat	PMID:1683769|RGD:2326143
Biological Process	GO:0014070	response to organic cyclic compound	Hmgcs1	IEP		Rat	PMID:19527300|RGD:2326111
Biological Process	GO:0010033	response to organic substance	Hmgcs1	IEP		Rat	PMID:3670308|RGD:728568
Biological Process	GO:0014074	response to purine-containing compound	Hmgcs1	IDA		Rat	PMID:16260|RGD:2302235
Biological Process	GO:0046690	response to tellurium ion	Hmgcs1	IEP		Rat	PMID:10642751|RGD:2326161
Biological Process	GO:0033197	response to vitamin E	Hmgcs1	IEP		Rat	PMID:15753162|RGD:2326153
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgcs1	IEP		Rat	PMID:16020911|RGD:2326152
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgcs1	IEP		Rat	PMID:17311803|RGD:2302234

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern