Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HMGCS2
  • Mouse genes Hmgcs2
  • Rat genes Hmgcs2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgcs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	HMGCS2	IMP		Human	PMID:23751782
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Hmgcs2	IDA		Mouse	MGI:MGI:5547422|PMID:24315375
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Hmgcs2	IDA		Rat	PMID:1971108|RGD:728512
Molecular Function	GO:0042802	identical protein binding	HMGCS2	IDA		Human	PMID:20346956
Cellular Component	GO:0005743	mitochondrial inner membrane	Hmgcs2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	Hmgcs2	IDA		Rat	PMID:17971398|RGD:2326115
Cellular Component	GO:0005739	mitochondrion	HMGCS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Hmgcs2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Hmgcs2	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Hmgcs2	HDA		Mouse	PMID:18614015
Biological Process	GO:0006084	acetyl-CoA metabolic process	HMGCS2	IMP		Human	PMID:23751782
Biological Process	GO:0060612	adipose tissue development	Hmgcs2	IEP		Rat	PMID:10357839|RGD:2326128
Biological Process	GO:0007420	brain development	Hmgcs2	IEP		Rat	PMID:34385|RGD:2326148
Biological Process	GO:0071230	cellular response to amino acid stimulus	Hmgcs2	IEP		Rat	PMID:20508999|RGD:2326106
Biological Process	GO:0071398	cellular response to fatty acid	Hmgcs2	IEP		Rat	PMID:20508999|RGD:2326106
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Hmgcs2	IEP		Rat	PMID:9798904|RGD:2326089
Biological Process	GO:0032870	cellular response to hormone stimulus	Hmgcs2	IEP		Rat	PMID:9025717|RGD:2326131
Biological Process	GO:0032869	cellular response to insulin stimulus	Hmgcs2	IEP		Rat	PMID:12027802|RGD:1599891
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Hmgcs2	IEP		Rat	PMID:11578593|RGD:1599044
Biological Process	GO:0071407	cellular response to organic cyclic compound	Hmgcs2	IEP		Rat	PMID:7694571|RGD:2326136
Biological Process	GO:0046951	ketone body biosynthetic process	HMGCS2	IMP		Human	PMID:23751782
Biological Process	GO:0046951	ketone body biosynthetic process	Hmgcs2	IEP		Rat	PMID:12399220|RGD:2326121
Biological Process	GO:0001822	kidney development	Hmgcs2	IEP		Rat	PMID:8099282|RGD:2326138
Biological Process	GO:0001889	liver development	Hmgcs2	IEP		Rat	PMID:8620869|RGD:2326125
Biological Process	GO:0030324	lung development	Hmgcs2	IEP		Rat	PMID:7911291|RGD:2326221
Biological Process	GO:0007494	midgut development	Hmgcs2	IEP		Rat	PMID:8620869|RGD:2326125
Biological Process	GO:0033555	multicellular organismal response to stress	Hmgcs2	IEP		Rat	PMID:16962226|RGD:2326150
Biological Process	GO:0009617	response to bacterium	Hmgcs2	IEP		Rat	PMID:14686922|RGD:2326119
Biological Process	GO:0051591	response to cAMP	Hmgcs2	IEP		Rat	PMID:7902069|RGD:2326135
Biological Process	GO:0045471	response to ethanol	Hmgcs2	IEP		Rat	PMID:17964421|RGD:2326116
Biological Process	GO:0070542	response to fatty acid	Hmgcs2	IEP		Rat	PMID:10796071|RGD:2326088
Biological Process	GO:0033762	response to glucagon	Hmgcs2	IEP		Rat	PMID:1967579|RGD:2326144
Biological Process	GO:0051384	response to glucocorticoid	Hmgcs2	IEP		Rat	PMID:9546617|RGD:2326129
Biological Process	GO:0060416	response to growth hormone	Hmgcs2	IEP		Rat	PMID:11551854|RGD:2326124
Biological Process	GO:0032868	response to insulin	Hmgcs2	IEP		Rat	PMID:9143333|RGD:2326130
Biological Process	GO:0070543	response to linoleic acid	Hmgcs2	IEP		Rat	PMID:16216487|RGD:2326151
Biological Process	GO:0010038	response to metal ion	Hmgcs2	IEP		Rat	PMID:8100835|RGD:2326137
Biological Process	GO:0034284	response to monosaccharide	Hmgcs2	IEP		Rat	PMID:1967579|RGD:2326144
Biological Process	GO:0007584	response to nutrient	Hmgcs2	IEP		Rat	PMID:17103110|RGD:1599890
Biological Process	GO:0014070	response to organic cyclic compound	Hmgcs2	IEP		Rat	PMID:20137896|RGD:2326109
Biological Process	GO:0043434	response to peptide hormone	Hmgcs2	IEP		Rat	PMID:12027802|RGD:1599891
Biological Process	GO:0034696	response to prostaglandin F	Hmgcs2	IEP		Rat	PMID:11517196|RGD:2300430
Biological Process	GO:0042594	response to starvation	Hmgcs2	IEP		Rat	PMID:10357839|RGD:2326128
Biological Process	GO:0009266	response to temperature stimulus	Hmgcs2	IEP		Rat	PMID:10357839|RGD:2326128
Biological Process	GO:0033574	response to testosterone	Hmgcs2	IEP		Rat	PMID:10357839|RGD:2326128
Biological Process	GO:0034014	response to triglyceride	Hmgcs2	IEP		Rat	PMID:11551854|RGD:2326124
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgcs2	IEP		Rat	PMID:11323196|RGD:2326160
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmgcs2	IEP		Rat	PMID:15107969|RGD:2326118

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern