Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hmox1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HMOX1
- Mouse genes Hmox1
- Rat genes Hmox1
- Zfish genes hmox1a,hmox1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmox1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Hmox1	IPI	UniProtKB:P00388	Rat	PMID:15516695\|RGD:8554849
Molecular Function	GO:0020037	heme binding	HMOX1	IDA		Human	PMID:17915953
Molecular Function	GO:0020037	heme binding	Hmox1	IDA		Rat	PMID:12044160\|RGD:730276
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	HMOX1	IMP		Human	PMID:11121422
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	HMOX1	IDA		Human	PMID:17915953
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	HMOX1	IMP		Human	PMID:19556236
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	HMOX1	IDA		Human	PMID:7703255
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	Hmox1	IDA		Rat	PMID:11854317\|RGD:625692
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	Hmox1	IDA		Rat	PMID:1575508\|RGD:151665734
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	Hmox1	IDA		Rat	PMID:1935972\|RGD:151665730
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	Hmox1	IDA		Rat	PMID:3865203\|RGD:8553416
Molecular Function	GO:0004392	heme oxygenase (decyclizing) activity	hmox1a	IMP	ZFIN:ZDB-MRPHLNO-160803-1	Zfish	PMID:26994186
Molecular Function	GO:0042802	identical protein binding	HMOX1	IPI	UniProtKB:P09601	Human	PMID:19556236
Molecular Function	GO:0004630	phospholipase D activity	Hmox1	IDA		Rat	PMID:12511545\|RGD:628519
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9NUX5	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:P29692-2	Human	PMID:21597468
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:O60669	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:O75208	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:P49447	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q15800	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q16623	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q53TN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q8TBP5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q96DZ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9BUF7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9BY50	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9H5J4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9NYP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HMOX1	IPI	UniProtKB:P0DTC3	Human	PMID:35239449
Molecular Function	GO:0005515	protein binding	Hmox1	IPI	RGD:2280	Rat	PMID:15226268\|RGD:1547877
Molecular Function	GO:0042803	protein homodimerization activity	HMOX1	IDA		Human	PMID:19556236
Molecular Function	GO:0005198	structural molecule activity	HMOX1	IMP		Human	PMID:19556236
Cellular Component	GO:0005901	caveola	Hmox1	IDA		Rat	PMID:15226268\|RGD:1547877
Cellular Component	GO:0005829	cytosol	Hmox1	IDA		Rat	PMID:14766239\|RGD:1547878
Cellular Component	GO:0005783	endoplasmic reticulum	HMOX1	IDA		Human	PMID:19556236
Cellular Component	GO:0005783	endoplasmic reticulum	HMOX1	IDA		Human	PMID:22503972
Cellular Component	GO:0005783	endoplasmic reticulum	Hmox1	IDA		Rat	PMID:15226268\|RGD:1547877
Cellular Component	GO:0005783	endoplasmic reticulum	Hmox1	IDA		Rat	PMID:3865203\|RGD:8553416
Cellular Component	GO:0005789	endoplasmic reticulum membrane	HMOX1	IDA		Human	PMID:22419571
Cellular Component	GO:0005730	nucleolus	Hmox1	IDA		Rat	PMID:14766239\|RGD:1547878
Cellular Component	GO:0005634	nucleus	Hmox1	IDA		Mouse	MGI:MGI:3799608\|PMID:17430897
Cellular Component	GO:0005634	nucleus	Hmox1	IDA		Rat	PMID:14766239\|RGD:1547878
Cellular Component	GO:0005634	nucleus	Hmox1	IDA		Rat	PMID:17430897\|RGD:8553479
Cellular Component	GO:0048471	perinuclear region of cytoplasm	HMOX1	IDA		Human	PMID:22503972
Biological Process	GO:0001525	angiogenesis	Hmox1	IDA		Rat	PMID:12593860\|RGD:1598394
Biological Process	GO:0071243	cellular response to arsenic-containing substance	Hmox1	IDA		Mouse	PMID:12220541
Biological Process	GO:0071276	cellular response to cadmium ion	Hmox1	IDA		Mouse	PMID:16183037
Biological Process	GO:0072719	cellular response to cisplatin	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0034605	cellular response to heat	HMOX1	IMP		Human	PMID:21597468
Biological Process	GO:0071456	cellular response to hypoxia	HMOX1	IEP		Human	PMID:12511571
Biological Process	GO:0031670	cellular response to nutrient	Hmox1	IEP		Rat	PMID:15531134\|RGD:1582714
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	hmox1a	IDA		Zfish	PMID:14691204
Biological Process	GO:1904019	epithelial cell apoptotic process	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0034101	erythrocyte homeostasis	HMOX1	IMP		Human	PMID:9884342
Biological Process	GO:0042167	heme catabolic process	HMOX1	IDA		Human	PMID:17915953
Biological Process	GO:0042167	heme catabolic process	Hmox1	IDA		Rat	PMID:15226268\|RGD:1547877
Biological Process	GO:0042168	heme metabolic process	Hmox1	IDA		Mouse	PMID:16183037
Biological Process	GO:0006788	heme oxidation	HMOX1	IDA		Human	PMID:17915953
Biological Process	GO:0006879	intracellular iron ion homeostasis	HMOX1	IDA		Human	PMID:17915953
Biological Process	GO:0006879	intracellular iron ion homeostasis	HMOX1	IMP		Human	PMID:22989377
Biological Process	GO:0035556	intracellular signal transduction	Hmox1	IDA		Rat	PMID:12225959\|RGD:625731
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Hmox1	IDA		Rat	PMID:11854317\|RGD:625692
Biological Process	GO:0097421	liver regeneration	Hmox1	IMP		Rat	PMID:24815159\|RGD:10755743
Biological Process	GO:0016236	macroautophagy	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	HMOX1	IMP		Human	PMID:9884342
Biological Process	GO:0008285	negative regulation of cell population proliferation	Hmox1	IDA		Rat	PMID:16319139\|RGD:1582710
Biological Process	GO:0043392	negative regulation of DNA binding	Hmox1	IDA		Rat	PMID:17234154\|RGD:1601626
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Hmox1	IDA		Rat	PMID:17234154\|RGD:1601626
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Hmox1	IMP		Rat	PMID:22093310\|RGD:10755586
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	HMOX1	IMP		Human	PMID:18202225
Biological Process	GO:0016242	negative regulation of macroautophagy	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0032764	negative regulation of mast cell cytokine production	Hmox1	IDA		Rat	PMID:17234154\|RGD:1601626
Biological Process	GO:0043305	negative regulation of mast cell degranulation	Hmox1	IDA		Rat	PMID:17234154\|RGD:1601626
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Hmox1	IDA		Rat	PMID:12396617\|RGD:728858
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Hmox1	IMP		Rat	PMID:19177228\|RGD:4145319
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	HMOX1	IDA		Human	PMID:17600318
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Hmox1	IMP		Rat	PMID:19885007\|RGD:4145298
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Hmox1	IMP		Rat	PMID:22709785\|RGD:10755720
Biological Process	GO:0045766	positive regulation of angiogenesis	HMOX1	IDA		Human	PMID:21788589
Biological Process	GO:0045766	positive regulation of angiogenesis	Hmox1	IMP		Rat	PMID:20925964\|RGD:4145134
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	HMOX1	IGI	RNAcentral:URS00001230A0_9606	Human	PMID:24844779
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	HMOX1	IGI	RNAcentral:URS00001230A0_9606	Human	PMID:24844779
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HMOX1	HMP		Human	PMID:12761501
Biological Process	GO:0016239	positive regulation of macroautophagy	Hmox1	IMP	MGI:MGI:2429784	Mouse	PMID:20705711
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	HMOX1	IDA		Human	PMID:17600318
Biological Process	GO:0008217	regulation of blood pressure	Hmox1	IDA		Rat	PMID:12215473\|RGD:1580453
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Hmox1	IDA		Rat	PMID:17430897\|RGD:8553479
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	hmox1a	IMP	ZFIN:ZDB-MRPHLNO-160803-1	Zfish	PMID:27581810
Biological Process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	Hmox1	IDA		Mouse	PMID:23395172
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	Hmox1	IDA		Rat	PMID:17430897\|RGD:8553479
Biological Process	GO:0043627	response to estrogen	Hmox1	IDA		Rat	PMID:15734876\|RGD:1582712
Biological Process	GO:0042542	response to hydrogen peroxide	Hmox1	IDA		Rat	PMID:17430897\|RGD:8553479
Biological Process	GO:0001666	response to hypoxia	Hmox1	IMP		Rat	PMID:12114196\|RGD:625603
Biological Process	GO:0001666	response to hypoxia	Hmox1	IEP		Rat	PMID:14970910\|RGD:1582715
Biological Process	GO:0001666	response to hypoxia	hmox1a	IDA		Zfish	PMID:14691204
Biological Process	GO:0035094	response to nicotine	HMOX1	IDA		Human	PMID:18205746
Biological Process	GO:0006979	response to oxidative stress	HMOX1	IMP		Human	PMID:9884342
Biological Process	GO:0006979	response to oxidative stress	Hmox1	IDA		Rat	PMID:17020887\|RGD:1601628
Biological Process	GO:0009410	response to xenobiotic stimulus	Hmox1	IEP		Rat	PMID:29091898\|RGD:15090820
Biological Process	GO:0007264	small GTPase mediated signal transduction	Hmox1	IDA		Rat	PMID:12511545\|RGD:628519
Biological Process	GO:0002246	wound healing involved in inflammatory response	HMOX1	IMP		Human	PMID:9884342

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.