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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hnf1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hnf1a
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003682chromatin bindingHnf1aIDAMousePMID:22780989
Molecular FunctionGO:0003677DNA bindingHNF1AIDAHumanPMID:1989880
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMouseMGI:MGI:2388420|PMID:12367519
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:16912278
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:1363228
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:2263635
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:11121425
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:9689059
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:16223943
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:15014077
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:8325367
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:11269503
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:1685988
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:16880268
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:15182178
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:7914432
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:8598044
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:15067314
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:15581617
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:2044952
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:1673925
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:14570708
Molecular FunctionGO:0003677DNA bindingHnf1aIDAMousePMID:11279518
Molecular FunctionGO:0003677DNA bindingHnf1aIDARatPMID:1763325|RGD:69920
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificHnf1aIDARatPMID:20735474|RGD:8553707
Molecular FunctionGO:0003700DNA-binding transcription factor activityHNF1AIDAHumanPMID:11980910
Molecular FunctionGO:0003700DNA-binding transcription factor activityHNF1AIDAHumanPMID:1989880
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMouseMGI:MGI:2388420|PMID:12367519
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:11279518
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIMPMGI:MGI:2154359MousePMID:8598044
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:11269503
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:2044952
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:1673925
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIMPMousePMID:16880268
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:2263635
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:11121425
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDAMousePMID:15067314
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1aIDARatPMID:1763325|RGD:69920
Molecular FunctionGO:0003690double-stranded DNA bindingHnf1aIDARatPMID:14561216|RGD:1599297
Molecular FunctionGO:0042802identical protein bindingHnf1aIPIPR:P22361MousePMID:1685988
Molecular FunctionGO:0042802identical protein bindingHnf1aIPIPR:P22361MousePMID:15182178
Molecular FunctionGO:0042802identical protein bindingHnf1aIPIPR:P22361MousePMID:2044952
Molecular FunctionGO:0005515protein bindingHNF1AIPIUniProtKB:Q9Y463HumanPMID:11980910
Molecular FunctionGO:0005515protein bindingHNF1AIPIUniProtKB:Q9Y463HumanPMID:14500717
Molecular FunctionGO:0005515protein bindingHNF1AIPIUniProtKB:Q92786HumanPMID:19264593
Molecular FunctionGO:0005515protein bindingHNF1AIPIUniProtKB:P61457HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingHNF1AIPIUniProtKB:P61457HumanPMID:35140242
Molecular FunctionGO:0005515protein bindingHnf1aIPIUniProtKB:Q99PV5MouseMGI:MGI:6282985|PMID:30555544
Molecular FunctionGO:0005515protein bindingHnf1aIPIUniProtKB:Q923I7MouseMGI:MGI:3619106|PMID:11269503
Molecular FunctionGO:0005515protein bindingHnf1aIPIUniProtKB:Q923E4MouseMGI:MGI:5315334|PMID:21176092
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:P27889MousePMID:2044952
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:Q91ZW3MousePMID:16880268
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:P27889MousePMID:1673925
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:P61458MousePMID:15182178
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:Q9CZL5MousePMID:15182178
Molecular FunctionGO:0005515protein bindingHnf1aIPIPR:P27889MousePMID:8598044
Molecular FunctionGO:0046983protein dimerization activityHNF1AIPIUniProtKB:P20823HumanPMID:12453420
Molecular FunctionGO:0046983protein dimerization activityHnf1aIPIUniProtKB:P22361MouseMGI:MGI:4821087|PMID:11106484
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingHnf1aIDAMousePMID:22589549
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingHnf1aIDAMousePMID:11287626
Molecular FunctionGO:0043565sequence-specific DNA bindingHnf1aIDARatPMID:12753154|RGD:1599299
Molecular FunctionGO:0043565sequence-specific DNA bindingHnf1aIDARatPMID:14561216|RGD:1599297
Molecular FunctionGO:0000976transcription cis-regulatory region bindingHNF1AIDAHumanPMID:12453420
Molecular FunctionGO:0000976transcription cis-regulatory region bindingHNF1AIDAHumanPMID:15961790
Molecular FunctionGO:0001223transcription coactivator bindingHnf1aIPIRGD:620036RatPMID:15598887|RGD:1581923
Molecular FunctionGO:0001221transcription coregulator bindingHnf1aIPIRGD:2401RatPMID:15598887|RGD:1581923
Cellular ComponentGO:0000785chromatinHnf1aIDARatPMID:15598887|RGD:1581923
Cellular ComponentGO:0005737cytoplasmHNF1AIDAHumanPMID:15355349
Cellular ComponentGO:0005737cytoplasmHnf1aIDAMousePMID:16880268
Cellular ComponentGO:0005634nucleusHNF1AIDAHumanPMID:15355349
Cellular ComponentGO:0005634nucleusHnf1aIDAMouseMGI:MGI:2388420|PMID:12367519
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:14656222
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:1685988
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:12189445
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:16223943
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:17272516
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:15647252
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:8598044
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:2044952
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:1363228
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:11121425
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:2263635
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:9689059
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:1673925
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:8330635
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:11269503
Cellular ComponentGO:0005634nucleusHnf1aIDAMousePMID:15182178
Cellular ComponentGO:0005634nucleusHnf1aIDARatPMID:12753154|RGD:1599299
Cellular ComponentGO:0005634nucleusHnf1aIDARatPMID:14561216|RGD:1599297
Cellular ComponentGO:0005634nucleusHnf1aIDARatPMID:1763325|RGD:69920
Cellular ComponentGO:0001750photoreceptor outer segmentHnf1aIGIMGI:MGI:96770MousePMID:10090727
Cellular ComponentGO:0045120pronucleusHnf1aIDAMousePMID:16880268
Cellular ComponentGO:0032991protein-containing complexHNF1AIDAHumanPMID:11980910
Cellular ComponentGO:0032991protein-containing complexHnf1aIDARatPMID:15598887|RGD:1581923
Cellular ComponentGO:0005667transcription regulator complexHnf1aIPIPR:P27889MousePMID:14570708
Biological ProcessGO:0032147activation of protein kinase activityHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0030262apoptotic nuclear changesHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0030262apoptotic nuclear changesHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0015721bile acid and bile salt transportHnf1aIMPMGI:MGI:2384427MousePMID:11279518
Biological ProcessGO:0006699bile acid biosynthetic processHnf1aIMPMGI:MGI:2384427MousePMID:11279518
Biological ProcessGO:0001824blastocyst developmentHnf1aIMPMousePMID:16880268
Biological ProcessGO:0045453bone resorptionHnf1aIGIMGI:MGI:88276MousePMID:15866165
Biological ProcessGO:0071333cellular response to glucose stimulusHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0071233cellular response to leucineHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0072752cellular response to rapamycinHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0008203cholesterol metabolic processHnf1aIMPMGI:MGI:2384427MousePMID:11279518
Biological ProcessGO:0006338chromatin remodelingHnf1aIMPMouseMGI:MGI:2388420|PMID:12367519
Biological ProcessGO:0006338chromatin remodelingHnf1aIMPMGI:MGI:2154359MousePMID:11733582
Biological ProcessGO:0030326embryonic limb morphogenesisHnf1aIGIMGI:MGI:96770MousePMID:10090727
Biological ProcessGO:0031018endocrine pancreas developmenthnf1aIMPZFIN:ZDB-MRPHLNO-160621-32ZfishPMID:26963759
Biological ProcessGO:0031018endocrine pancreas developmenthnf1aIMPZFIN:ZDB-CRISPR-160729-19ZfishPMID:26963759
Biological ProcessGO:0006633fatty acid biosynthetic processHnf1aIMPMGI:MGI:2384429MousePMID:10852923
Biological ProcessGO:0015908fatty acid transportHnf1aIMPMGI:MGI:2384429MousePMID:10852923
Biological ProcessGO:0042593glucose homeostasisHNF1AIMPHumanPMID:11269503
Biological ProcessGO:0042593glucose homeostasisHNF1AIMPHumanPMID:15277395
Biological ProcessGO:0042593glucose homeostasisHnf1aIDAMouseMGI:MGI:3619106|PMID:11269503
Biological ProcessGO:0042593glucose homeostasisHnf1aIMPMGI:MGI:2384429MousePMID:11121425
Biological ProcessGO:0042593glucose homeostasisHnf1aIMPMGI:MGI:2154359MousePMID:9593777
Biological ProcessGO:0042593glucose homeostasisHnf1aIMPMGI:MGI:2154359MousePMID:11269503
Biological ProcessGO:0046323glucose importHNF1AIMPHumanPMID:11269503
Biological ProcessGO:0046323glucose importHnf1aIDAMouseMGI:MGI:3619106|PMID:11269503
Biological ProcessGO:0006783heme biosynthetic processHnf1aIMPMGI:MGI:2384429MousePMID:10617683
Biological ProcessGO:0030073insulin secretionHnf1aIMPMGI:MGI:2384429MousePMID:9733737
Biological ProcessGO:0030073insulin secretionHnf1aIMPMGI:MGI:2154359MousePMID:15142986
Biological ProcessGO:0030073insulin secretionHnf1aIMPMGI:MGI:2154359MousePMID:9593777
Biological ProcessGO:0030073insulin secretionHnf1aIMPMGI:MGI:2384429MousePMID:9566924
Biological ProcessGO:0001889liver developmentHnf1aIMPMGI:MGI:2384429MousePMID:9566924
Biological ProcessGO:0043066negative regulation of apoptotic processHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0043066negative regulation of apoptotic processHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:1903799negative regulation of miRNA processingHnf1aIMPRatPMID:23674172|RGD:150540303
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHnf1aIDARatPMID:7937157|RGD:730004
Biological ProcessGO:0048341paraxial mesoderm formationHnf1aIGIMGI:MGI:96770MousePMID:10090727
Biological ProcessGO:0001890placenta developmentHnf1aIGIMGI:MGI:96770MousePMID:10090727
Biological ProcessGO:2001171positive regulation of ATP biosynthetic processHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHNF1AIDAHumanPMID:11980910
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHNF1AIDAHumanPMID:12453420
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHNF1AIDAHumanPMID:1989880
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMouseMGI:MGI:6282985|PMID:30555544
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMouseMGI:MGI:2388420|PMID:12367519
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:14656222
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:10852923
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:10631168
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:11121425
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMousePMID:14656222
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2154359MousePMID:11733582
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:1673925
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:15067314
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2384429MousePMID:14656222
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:11279518
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:2263635
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2384429MousePMID:10617683
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:2044952
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2384429MousePMID:16873682
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:11269503
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIDAMousePMID:16873682
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2384427MousePMID:15793583
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2154359MousePMID:8598044
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1aIMPMGI:MGI:2384429MousePMID:16223943
Biological ProcessGO:0010628positive regulation of gene expressionHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0032024positive regulation of insulin secretionHnf1aIEPRatPMID:10944108|RGD:150540301
Biological ProcessGO:0010918positive regulation of mitochondrial membrane potentialHnf1aIMPRatPMID:10944108|RGD:150540301
Biological ProcessGO:0051897positive regulation of protein kinase B signalingHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0001934positive regulation of protein phosphorylationHnf1aIMPRatPMID:21874357|RGD:150540304
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIMPMGI:MGI:2384429MousePMID:11287626
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIMPMGI:MGI:2384429MousePMID:17272516
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIDAMousePMID:15581617
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIMPRatPMID:15598887|RGD:1581923
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIDARatPMID:20735474|RGD:8553707
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1aIDARatPMID:7937157|RGD:730004
Biological ProcessGO:0060261positive regulation of transcription initiation by RNA polymerase IIHNF1AIGIUniProtKB:P35680HumanPMID:15355349
Biological ProcessGO:0008104protein localizationHnf1aIMPMousePMID:16880268
Biological ProcessGO:0006355regulation of DNA-templated transcriptionHnf1aIMPMousePMID:16880268
Biological ProcessGO:0046883regulation of hormone secretionHnf1aIMPMGI:MGI:2384429MousePMID:9566924
Biological ProcessGO:1902031regulation of NADP metabolic processHnf1aIMPRatPMID:20841353|RGD:150540305
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIHNF1AIDAHumanPMID:10330009
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIHnf1aIGIMGI:MGI:109128MousePMID:22589549
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIHnf1aIDAMousePMID:9689059
Biological ProcessGO:0030111regulation of Wnt signaling pathwayHnf1aIGIMGI:MGI:96770MousePMID:10090727
Biological ProcessGO:0035623renal glucose absorptionHNF1AIMPHumanPMID:11269503
Biological ProcessGO:0035623renal glucose absorptionHnf1aIDAMouseMGI:MGI:3619106|PMID:11269503
Biological ProcessGO:0048608reproductive structure developmentHnf1aIMPMGI:MGI:2384429MousePMID:9566924
Biological ProcessGO:0009749response to glucoseHnf1aIMPMGI:MGI:2384429MousePMID:9733737
Biological ProcessGO:0006979response to oxidative stressHnf1aIMPMGI:MGI:2384429MousePMID:10617683
Biological ProcessGO:0043691reverse cholesterol transportHnf1aIMPMGI:MGI:2384427MousePMID:15793583
Biological ProcessGO:0060395SMAD protein signal transductionHnf1aIDAMousePMID:9420335
Biological ProcessGO:0006366transcription by RNA polymerase IIHnf1aIDARatPMID:14561216|RGD:1599297
Biological ProcessGO:0003323type B pancreatic cell developmenthnf1aIMPZFIN:ZDB-MRPHLNO-160621-32ZfishPMID:26963759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory