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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hnf1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hnf1b
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingHnf1bIDAMousePMID:1685988
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingHnf1bIDAMousePMID:15067314
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingHnf1bIDAMousePMID:14570708
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingHnf1bIDAMousePMID:16274963
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingHnf1bIDARatPMID:1673926|RGD:729944
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:1673925
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:1363228
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:2044952
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:15509593
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:16912278
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:15647252
Molecular FunctionGO:0003677DNA bindingHnf1bIDAMousePMID:8598044
Molecular FunctionGO:0003700DNA-binding transcription factor activityHNF1BIDAHumanPMID:16297991
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMouseMGI:MGI:2388420|PMID:12367519
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMousePMID:16274963
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMousePMID:15067314
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMousePMID:1673925
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMousePMID:15509593
Molecular FunctionGO:0003700DNA-binding transcription factor activityHnf1bIDAMousePMID:15647252
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificHnf1bIDAMousePMID:20040500
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificHnf1bIDARatPMID:12860991|RGD:1599302
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:1673925
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:1685988
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:1363228
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:2044952
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:15647252
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIPR:P27889MousePMID:8598044
Molecular FunctionGO:0042802identical protein bindingHnf1bIPIRGD:3830RatPMID:1673926|RGD:729944
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P61457HumanPMID:20211142
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P29674HumanPMID:21281489
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:O43186HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P32243-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P55197-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P61457HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P78424HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q08AM6HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q5SWW7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q6NVU6HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q6PEX3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q70EL1-9HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q8TDS5HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:Q9NP55HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingHNF1BIPIUniProtKB:P61457HumanPMID:35140242
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P22361MousePMID:1685988
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:Q9JHD1MousePMID:15509593
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P22361MousePMID:8598044
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P22361MousePMID:1673925
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:O09106MousePMID:15509593
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P22361MousePMID:2044952
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P45481MousePMID:15647252
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:Q9JHD1MousePMID:15647252
Molecular FunctionGO:0005515protein bindingHnf1bIPIPR:P45481MousePMID:15509593
Molecular FunctionGO:0044877protein-containing complex bindingHnf1bIDARatPMID:1673926|RGD:729944
Molecular FunctionGO:0044877protein-containing complex bindingHnf1bIDARatPMID:9523012|RGD:2312722
Molecular FunctionGO:0043565sequence-specific DNA bindingHnf1bIDARatPMID:12860991|RGD:1599302
Molecular FunctionGO:0000976transcription cis-regulatory region bindingHnf1bIDAMousePMID:20040500
Cellular ComponentGO:0043231intracellular membrane-bounded organelleHNF1BIDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmHNF1BIDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusHNF1BIDAHumanPMID:15355349
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:15280201
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:1363228
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:16880268
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:1673925
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:15550389
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:1685988
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:8598044
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:15067314
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:15647252
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:14656222
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:15509593
Cellular ComponentGO:0005634nucleusHnf1bIDAMousePMID:2044952
Cellular ComponentGO:0005634nucleusHnf1bIDARatPMID:9545279|RGD:2312721
Cellular ComponentGO:0005667transcription regulator complexHnf1bIPIPR:P22361MousePMID:14570708
Biological ProcessGO:0009952anterior/posterior pattern specificationHnf1bIMPMGI:MGI:2176174,MGI:MGI:2670936MousePMID:15872003
Biological ProcessGO:0009952anterior/posterior pattern specificationhnf1baIMPZFIN:ZDB-GENO-070830-1ZfishPMID:12835397
Biological ProcessGO:0009952anterior/posterior pattern specificationhnf1baIMPZFIN:ZDB-GENO-030715-3ZfishPMID:15342476
Biological ProcessGO:0009952anterior/posterior pattern specificationhnf1baIGIZFIN:ZDB-GENE-980526-178,ZFIN:ZDB-GENE-990415-72ZfishPMID:15342476
Biological ProcessGO:0009952anterior/posterior pattern specificationhnf1baIMPZfishPMID:15342476
Biological ProcessGO:0034672anterior/posterior pattern specification involved in pronephros developmenthnf1baIGIZFIN:ZDB-GENO-090923-3,ZFIN:ZDB-MRPHLNO-090923-1ZfishPMID:23160512
Biological ProcessGO:0034672anterior/posterior pattern specification involved in pronephros developmenthnf1bbIGIZFIN:ZDB-GENO-090923-3,ZFIN:ZDB-MRPHLNO-090923-1ZfishPMID:23160512
Biological ProcessGO:0006915apoptotic processHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0048754branching morphogenesis of an epithelial tubeHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0032922circadian regulation of gene expressionHnf1bIDARatPMID:9545279|RGD:2312721
Biological ProcessGO:0048546digestive tract morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17632505
Biological ProcessGO:0048566embryonic digestive tract developmenthnf1baIMPZFIN:ZDB-GENO-020426-26ZfishPMID:11731484
Biological ProcessGO:0048557embryonic digestive tract morphogenesisHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0048598embryonic morphogenesisHnf1bIDARatPMID:12860991|RGD:1599302
Biological ProcessGO:0031018endocrine pancreas developmenthnf1baIMPZFIN:ZDB-MRPHLNO-160621-34ZfishPMID:26963759
Biological ProcessGO:0007492endoderm developmentHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0007492endoderm developmentHnf1bIMPMGI:MGI:1857856MousePMID:10518496
Biological ProcessGO:0007492endoderm developmentHnf1bIMPMGI:MGI:2181390MousePMID:10518495
Biological ProcessGO:0001706endoderm formationhnf1baIDAZfishPMID:18635606|ZFIN:ZDB-PUB-080722-19
Biological ProcessGO:0001714endodermal cell fate specificationHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0050673epithelial cell proliferationHnf1bIMPMousePMID:15647252
Biological ProcessGO:0060429epithelium developmentHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0042593glucose homeostasishnf1baIMPZFIN:ZDB-MRPHLNO-160621-34ZfishPMID:26963759
Biological ProcessGO:0061008hepaticobiliary system developmenthnf1baIGIZFIN:ZDB-GENO-130823-13ZfishPMID:23720049
Biological ProcessGO:0061017hepatoblast differentiationHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0070365hepatocyte differentiationHnf1bIEPRatPMID:18286537|RGD:2312718
Biological ProcessGO:0030902hindbrain developmentHnf1bIMPMGI:MGI:2176174,MGI:MGI:2670936MousePMID:15872003
Biological ProcessGO:0030902hindbrain developmenthnf1baIMPZfishPMID:18945197|ZFIN:ZDB-PUB-081029-2
Biological ProcessGO:0030902hindbrain developmenthnf1baIMPZFIN:ZDB-GENO-030715-3ZfishPMID:11731484
Biological ProcessGO:0021575hindbrain morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17522161
Biological ProcessGO:0001826inner cell mass cell differentiationHnf1bIMPMGI:MGI:1857856MousePMID:10518496
Biological ProcessGO:0030073insulin secretionHnf1bIMPMGI:MGI:2176227,MGI:MGI:2670936MousePMID:15142986
Biological ProcessGO:0035622intrahepatic bile duct developmenthnf1baIGIZFIN:ZDB-MRPHLNO-110413-4ZfishPMID:21215262
Biological ProcessGO:0001822kidney developmentHNF1BIMPHumanPMID:10720943
Biological ProcessGO:0001822kidney developmentHNF1BIDAHumanPMID:21281489
Biological ProcessGO:0001822kidney developmentHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0060993kidney morphogenesisHnf1bIGIMGI:MGI:98957MousePMID:23362348
Biological ProcessGO:0001889liver developmentHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0001889liver developmenthnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:18635606
Biological ProcessGO:0001889liver developmenthnf1baIGIZFIN:ZDB-GENO-130823-13ZfishPMID:23720049
Biological ProcessGO:0072576liver morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:20413782
Biological ProcessGO:1900200mesenchymal cell apoptotic process involved in metanephros developmentHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0072177mesonephric duct developmentHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0072181mesonephric duct formationHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0072164mesonephric tubule developmentHnf1bIGIMGI:MGI:1197020MousePMID:20040500
Biological ProcessGO:0072164mesonephric tubule developmentHnf1bIGIMGI:MGI:98957MousePMID:20040500
Biological ProcessGO:0043066negative regulation of apoptotic processHnf1bIMPMGI:MGI:1857856MousePMID:18635606
Biological ProcessGO:0061296negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesisHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:1900212negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIHnf1bIDAMousePMID:18635606
Biological ProcessGO:0072176nephric duct developmentHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0072179nephric duct formationHnf1bIMPMGI:MGI:1857856MousePMID:19913010
Biological ProcessGO:0007219Notch signaling pathwayHnf1bIDAMousePMID:25446530
Biological ProcessGO:0043049otic placode formationhnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17137573
Biological ProcessGO:0030916otic vesicle formationhnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17137573
Biological ProcessGO:0030916otic vesicle formationhnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17522161
Biological ProcessGO:0048840otolith developmenthnf1baIGIZFIN:ZDB-GENO-070430-5,ZFIN:ZDB-GENO-070523-1ZfishPMID:17522161
Biological ProcessGO:0032474otolith morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17137573
Biological ProcessGO:0031016pancreas developmenthnf1baIGIZFIN:ZDB-GENO-130823-13ZfishPMID:23720049
Biological ProcessGO:0031016pancreas developmenthnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:18635606
Biological ProcessGO:0031016pancreas developmenthnf1baIMPZFIN:ZDB-GENO-130823-20ZfishPMID:23720049
Biological ProcessGO:1990798pancreas regenerationhnf1baIMPZFIN:ZDB-MRPHLNO-160621-34ZfishPMID:26963759
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHNF1BIDAHumanPMID:16297991
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHNF1BIDAHumanPMID:21281489
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1bIDAMousePMID:15509593
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1bIDAMousePMID:20040500
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1bIDAMousePMID:15647252
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1bIDAMousePMID:15067314
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionHnf1bIDAMousePMID:1673925
Biological ProcessGO:0010628positive regulation of gene expressionHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1bIDAMousePMID:18635606
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1bIDAMousePMID:16274963
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1bIDARatPMID:12860991|RGD:1599302
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIHnf1bIMPRatPMID:1673926|RGD:729944
Biological ProcessGO:0060261positive regulation of transcription initiation by RNA polymerase IIHNF1BIDAHumanPMID:15355349
Biological ProcessGO:0039020pronephric nephron tubule developmentHNF1BIGIUniProtKB:P29674HumanPMID:15355349
Biological ProcessGO:0039020pronephric nephron tubule developmentHNF1BIGIUniProtKB:Q9PUK5HumanPMID:15355349
Biological ProcessGO:0048793pronephros developmentHNF1BIMPHumanPMID:15355349
Biological ProcessGO:0065004protein-DNA complex assemblyHnf1bIMPRatPMID:9545279|RGD:2312721
Biological ProcessGO:0072095regulation of branch elongation involved in ureteric bud branchingHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0035565regulation of pronephros sizeHNF1BIMPHumanPMID:15355349
Biological ProcessGO:0030111regulation of Wnt signaling pathwayHnf1bIMPMGI:MGI:1857856MousePMID:20040500
Biological ProcessGO:0009743response to carbohydrateHnf1bIEPRatPMID:10580588|RGD:2312720
Biological ProcessGO:0009749response to glucoseHnf1bIMPMGI:MGI:2176227,MGI:MGI:2670936MousePMID:15142986
Biological ProcessGO:0014070response to organic cyclic compoundHnf1bIEPRatPMID:12051991|RGD:1599031
Biological ProcessGO:0009410response to xenobiotic stimulusHnf1bIEPRatPMID:18656965|RGD:2312717
Biological ProcessGO:0021571rhombomere 5 developmenthnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:29945667
Biological ProcessGO:0021571rhombomere 5 developmenthnf1baIMPZFIN:ZDB-GENO-070830-1ZfishPMID:12835397
Biological ProcessGO:0021664rhombomere 5 morphogenesishnf1baIMPZFIN:ZDB-GENO-090923-3ZfishPMID:18945197
Biological ProcessGO:0021664rhombomere 5 morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:18945197
Biological ProcessGO:0021572rhombomere 6 developmenthnf1baIMPZFIN:ZDB-GENO-070830-1ZfishPMID:12835397
Biological ProcessGO:0021572rhombomere 6 developmenthnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:29945667
Biological ProcessGO:0021667rhombomere 6 morphogenesishnf1baIMPZFIN:ZDB-GENO-090923-3ZfishPMID:18945197
Biological ProcessGO:0021667rhombomere 6 morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:18945197
Biological ProcessGO:0048752semicircular canal morphogenesishnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17137573
Biological ProcessGO:0035148tube formationhnf1baIMPZFIN:ZDB-GENO-070523-1ZfishPMID:17632505
Biological ProcessGO:0003323type B pancreatic cell developmenthnf1baIMPZFIN:ZDB-MRPHLNO-160621-34ZfishPMID:26963759
Biological ProcessGO:0003323type B pancreatic cell developmenthnf1baIMPZFIN:ZDB-GENO-130813-4ZfishPMID:23720049
Biological ProcessGO:0060677ureteric bud elongationHnf1bIMPMGI:MGI:1857856MousePMID:20040500

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory