Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HNF4A
  • Mouse genes Hnf4a
  • Rat genes Hnf4a
  • Zfish genes hnf4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hnf4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050544	arachidonic acid binding	Hnf4a	IDA		Rat	PMID:11940586|RGD:625581
Molecular Function	GO:0003682	chromatin binding	Hnf4a	IDA		Mouse	PMID:22780989
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Hnf4a	IDA		Rat	PMID:16640558|RGD:12904755
Molecular Function	GO:0003677	DNA binding	HNF4A	IDA		Human	PMID:10551874
Molecular Function	GO:0003677	DNA binding	HNF4A	IDA		Human	PMID:7615825
Molecular Function	GO:0003677	DNA binding	Hnf4a	IDA		Mouse	PMID:15581617
Molecular Function	GO:0003677	DNA binding	Hnf4a	IDA		Mouse	PMID:15014077
Molecular Function	GO:0003677	DNA binding	Hnf4a	IDA		Mouse	PMID:16912278
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hnf4a	IDA		Mouse	PMID:27471003
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Hnf4a	IDA		Rat	PMID:20735474|RGD:8553707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HNF4A	IDA		Human	PMID:10330009
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HNF4A	IDA		Human	PMID:12911579
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HNF4A	IDA		Human	PMID:16488887
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HNF4A	IDA		Human	PMID:7615825
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hnf4a	IDA		Mouse	MGI:MGI:3575336|PMID:15761495
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Hnf4a	IDA		Mouse	PMID:16498401
Molecular Function	GO:0003700	DNA-binding transcription factor activity	hnf4a	IGI	ZFIN:ZDB-GENO-171107-21	Zfish	PMID:28385711
Molecular Function	GO:0003700	DNA-binding transcription factor activity	hnf4a	IGI	ZFIN:ZDB-GENO-171107-22	Zfish	PMID:28385711
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Hnf4a	IDA		Mouse	PMID:10859308
Molecular Function	GO:0005504	fatty acid binding	HNF4A	IDA		Human	PMID:12220494
Molecular Function	GO:0005504	fatty acid binding	Hnf4a	IPI	PubChem_Compound:985	Rat	PMID:15870076|RGD:1625002
Molecular Function	GO:0000062	fatty-acyl-CoA binding	Hnf4a	IPI	PubChem_Compound:644109	Rat	PMID:15870076|RGD:1625002
Molecular Function	GO:0036042	long-chain fatty acyl-CoA binding	Hnf4a	IDA		Rat	PMID:11940586|RGD:625581
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity	Hnf4a	IDA		Rat	PMID:15870076|RGD:1625002
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q12772	Human	PMID:12855700
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q92786	Human	PMID:16488887
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q99967	Human	PMID:17932483
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:P04150	Human	PMID:17978169
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:P37840	Human	PMID:19549071
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q9UBK2	Human	PMID:19846556
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O75151	Human	PMID:21532585
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:P23246	Human	PMID:23714182
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:A8MYZ6	Human	PMID:23714368
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O00571	Human	PMID:28128295
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O00327	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O15055	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O15516	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:O15534	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q16526	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	HNF4A	IPI	UniProtKB:Q49AN0	Human	PMID:30530698
Molecular Function	GO:0005515	protein binding	Hnf4a	IPI	UniProtKB:O54943	Mouse	MGI:MGI:4429726|PMID:20159955
Molecular Function	GO:0005515	protein binding	Hnf4a	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:5913754|PMID:28751364
Molecular Function	GO:0005515	protein binding	Hnf4a	IPI	PR:Q9WTN3	Mouse	PMID:17636037
Molecular Function	GO:0005515	protein binding	Hnf4a	IPI	RGD:2490	Rat	PMID:14530276|RGD:2316269
Molecular Function	GO:0005515	protein binding	Hnf4a	IPI	UniProtKB:P02692	Rat	PMID:24140341|RGD:8553697
Molecular Function	GO:0019904	protein domain specific binding	Hnf4a	IPI	RGD:1321111	Rat	PMID:12205093|RGD:152995266
Molecular Function	GO:0042803	protein homodimerization activity	HNF4A	IDA		Human	PMID:12220494
Molecular Function	GO:0044877	protein-containing complex binding	Hnf4a	IPI	RGD:1351174,RGD:1343127,RGD:1316995130	Rat	PMID:12089346|RGD:152985545
Molecular Function	GO:0044877	protein-containing complex binding	Hnf4a	IDA		Rat	PMID:12205093|RGD:152995266
Molecular Function	GO:0044877	protein-containing complex binding	Hnf4a	IMP		Rat	PMID:2279702|RGD:1298950
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hnf4a	IDA		Mouse	PMID:22589549
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Hnf4a	IPI	UniProtKB:O35740	Mouse	MGI:MGI:3813432|PMID:17932483
Molecular Function	GO:0043565	sequence-specific DNA binding	Hnf4a	IDA		Mouse	PMID:8306889
Molecular Function	GO:0043565	sequence-specific DNA binding	Hnf4a	IMP		Rat	PMID:16893891|RGD:1624992
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HNF4A	IDA		Human	PMID:28473536
Molecular Function	GO:0005102	signaling receptor binding	HNF4A	IDA		Human	PMID:12220494
Molecular Function	GO:0070540	stearic acid binding	Hnf4a	IDA		Rat	PMID:11940586|RGD:625581
Molecular Function	GO:0000976	transcription cis-regulatory region binding	HNF4A	IDA		Human	PMID:16488887
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Hnf4a	IDA		Mouse	MGI:MGI:3575336|PMID:15761495
Molecular Function	GO:0001221	transcription coregulator binding	Hnf4a	IPI	UniProtKB:P51843	Rat	PMID:19651776|RGD:8553501
Molecular Function	GO:0001222	transcription corepressor binding	Hnf4a	IPI	RGD:1321111	Rat	PMID:12205093|RGD:152995266
Cellular Component	GO:0005737	cytoplasm	HNF4A	IDA		Human	PMID:14563941
Cellular Component	GO:0005737	cytoplasm	Hnf4a	IDA		Rat	PMID:16799975|RGD:2301842
Cellular Component	GO:0005654	nucleoplasm	HNF4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HNF4A	IDA		Human	PMID:14563941
Cellular Component	GO:0005634	nucleus	HNF4A	IDA		Human	PMID:15574752
Cellular Component	GO:0005634	nucleus	HNF4A	IDA		Human	PMID:7615825
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:17021047
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:8306889
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:9408084
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:15767668
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:16537911
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Mouse	PMID:9421506
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0005634	nucleus	Hnf4a	IDA		Rat	PMID:19651776|RGD:8553501
Biological Process	GO:0006637	acyl-CoA metabolic process	Hnf4a	IDA		Rat	PMID:15870076|RGD:1625002
Biological Process	GO:0007568	aging	Hnf4a	IEP		Rat	PMID:24177414|RGD:10445837
Biological Process	GO:0007596	blood coagulation	HNF4A	IDA		Human	PMID:12911579
Biological Process	GO:0030154	cell differentiation	Hnf4a	IMP		Rat	PMID:16563856|RGD:1625014
Biological Process	GO:0045216	cell-cell junction organization	Hnf4a	IDA		Rat	PMID:12749857|RGD:1625017
Biological Process	GO:0071456	cellular response to hypoxia	Hnf4a	IEP		Rat	PMID:24177414|RGD:10445837
Biological Process	GO:0042632	cholesterol homeostasis	Hnf4a	IMP		Mouse	MGI:MGI:1930468|PMID:11158324
Biological Process	GO:0006351	DNA-templated transcription	hnf4a	IGI	ZFIN:ZDB-GENO-171107-22	Zfish	PMID:28385711|ZFIN:ZDB-PUB-170408-8
Biological Process	GO:0031018	endocrine pancreas development	hnf4a	IMP	ZFIN:ZDB-MRPHLNO-160621-36	Zfish	PMID:26963759
Biological Process	GO:0007164	establishment of tissue polarity	Hnf4a	IDA		Rat	PMID:12749857|RGD:1625017
Biological Process	GO:0042593	glucose homeostasis	Hnf4a	IMP		Mouse	MGI:MGI:3575336|PMID:15761495
Biological Process	GO:0070365	hepatocyte differentiation	Hnf4a	IEP		Rat	PMID:19621519|RGD:12904750
Biological Process	GO:0055088	lipid homeostasis	HNF4A	IMP		Human	PMID:17827783
Biological Process	GO:0006629	lipid metabolic process	Hnf4a	IMP	MGI:MGI:3622274	Mouse	PMID:16498401
Biological Process	GO:1902569	negative regulation of activation of Janus kinase activity	Hnf4a	IDA		Rat	PMID:16584384|RGD:1625011
Biological Process	GO:0030308	negative regulation of cell growth	HNF4A	IMP		Human	PMID:18163890
Biological Process	GO:0030336	negative regulation of cell migration	Hnf4a	IDA		Rat	PMID:12036449|RGD:12904771
Biological Process	GO:0008285	negative regulation of cell population proliferation	HNF4A	IMP		Human	PMID:18163890
Biological Process	GO:0008285	negative regulation of cell population proliferation	Hnf4a	IDA		Rat	PMID:15541721|RGD:1625019
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Hnf4a	IDA		Rat	PMID:16584384|RGD:1625011
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	HNF4A	IDA		Human	PMID:30530698
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	Hnf4a	IDA		Rat	PMID:15541721|RGD:1625019
Biological Process	GO:0042308	negative regulation of protein import into nucleus	Hnf4a	IDA		Rat	PMID:16584384|RGD:1625011
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Hnf4a	IDA		Rat	PMID:16584384|RGD:1625011
Biological Process	GO:0006591	ornithine metabolic process	HNF4A	IMP		Human	PMID:17827783
Biological Process	GO:1990798	pancreas regeneration	hnf4a	IMP	ZFIN:ZDB-MRPHLNO-160621-36	Zfish	PMID:26963759
Biological Process	GO:0055091	phospholipid homeostasis	Hnf4a	IMP		Mouse	MGI:MGI:1930468|PMID:11158324
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HNF4A	IDA		Human	PMID:16488887
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hnf4a	IDA		Mouse	MGI:MGI:6282985|PMID:30555544
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hnf4a	IDA		Mouse	PMID:9421506
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hnf4a	IDA		Mouse	PMID:27471003
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hnf4a	IDA		Mouse	PMID:9408084
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Hnf4a	IDA		Rat	PMID:19651776|RGD:8553501
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	Hnf4a	IMP		Rat	PMID:16800817|RGD:1624995
Biological Process	GO:0010628	positive regulation of gene expression	Hnf4a	IGI	RGD:1351174	Rat	PMID:12089346|RGD:152985545
Biological Process	GO:0010628	positive regulation of gene expression	Hnf4a	IMP		Rat	PMID:12205093|RGD:152995266
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Hnf4a	IMP		Rat	PMID:16893891|RGD:1624992
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Hnf4a	IMP		Rat	PMID:24177414|RGD:10445837
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HNF4A	IDA		Human	PMID:7615825
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HNF4A	IMP		Human	PMID:17827783
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HNF4A	IMP		Human	PMID:30597922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IMP		Mouse	MGI:MGI:1930468|PMID:11158324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Mouse	MGI:MGI:3575336|PMID:15761495
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IGI	MGI:MGI:1342774	Mouse	PMID:17636037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IGI	MGI:MGI:1276523	Mouse	PMID:17636037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IMP	MGI:MGI:3622274	Mouse	PMID:16537911
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IGI	MGI:MGI:1276533	Mouse	PMID:17636037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Mouse	PMID:17636037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Mouse	PMID:16527247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Mouse	PMID:15581617
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IGI	MGI:MGI:1276535	Mouse	PMID:17636037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Mouse	PMID:10859308
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IMP		Rat	PMID:16893891|RGD:1624992
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnf4a	IDA		Rat	PMID:20735474|RGD:8553707
Biological Process	GO:0042752	regulation of circadian rhythm	HNF4A	IMP		Human	PMID:30530698
Biological Process	GO:0042752	regulation of circadian rhythm	Hnf4a	IMP		Mouse	MGI:MGI:6272229|PMID:30530698
Biological Process	GO:0006355	regulation of DNA-templated transcription	Hnf4a	IMP	MGI:MGI:2158682	Mouse	PMID:9053305
Biological Process	GO:0006355	regulation of DNA-templated transcription	hnf4a	IGI	ZFIN:ZDB-GENO-171107-22	Zfish	PMID:28385711|ZFIN:ZDB-PUB-170408-8
Biological Process	GO:0010470	regulation of gastrulation	Hnf4a	IMP	MGI:MGI:2158682	Mouse	PMID:7958910
Biological Process	GO:0050796	regulation of insulin secretion	Hnf4a	IMP		Mouse	MGI:MGI:3575336|PMID:15761495
Biological Process	GO:0019216	regulation of lipid metabolic process	HNF4A	IDA		Human	PMID:10551874
Biological Process	GO:0032534	regulation of microvillus assembly	Hnf4a	IMP		Rat	PMID:17178913|RGD:2301840
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	HNF4A	IDA		Human	PMID:10330009
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	HNF4A	IDA		Human	PMID:12911579
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	HNF4A	IMP		Human	PMID:18163890
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Hnf4a	IMP		Mouse	PMID:22589549
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Hnf4a	IGI	MGI:MGI:98504	Mouse	PMID:22589549
Biological Process	GO:0009617	response to bacterium	hnf4a	IMP	ZFIN:ZDB-GENO-171107-19	Zfish	PMID:28385711
Biological Process	GO:0009617	response to bacterium	hnf4a	IMP	ZFIN:ZDB-GENO-171107-20	Zfish	PMID:28385711
Biological Process	GO:0051591	response to cAMP	Hnf4a	IEP		Rat	PMID:16799975|RGD:2301842
Biological Process	GO:0071548	response to dexamethasone	Hnf4a	IEP		Rat	PMID:16570165|RGD:1625508
Biological Process	GO:0009749	response to glucose	Hnf4a	IMP		Mouse	MGI:MGI:3575336|PMID:15761495
Biological Process	GO:0009749	response to glucose	Hnf4a	IDA		Rat	PMID:16800817|RGD:1624995
Biological Process	GO:0032496	response to lipopolysaccharide	Hnf4a	IEP		Rat	PMID:11679969|RGD:12904749
Biological Process	GO:0031667	response to nutrient levels	Hnf4a	IEP		Rat	PMID:17640976|RGD:12904758
Biological Process	GO:0035983	response to trichostatin A	Hnf4a	IDA		Rat	PMID:12205093|RGD:152995266
Biological Process	GO:0009410	response to xenobiotic stimulus	Hnf4a	IEP		Rat	PMID:16799975|RGD:2301842
Biological Process	GO:0007548	sex differentiation	Hnf4a	IMP	MGI:MGI:2183520	Mouse	PMID:17412818
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Hnf4a	IDA		Mouse	PMID:18462699
Biological Process	GO:0060395	SMAD protein signal transduction	Hnf4a	IDA		Mouse	PMID:9420335
Biological Process	GO:0006366	transcription by RNA polymerase II	Hnf4a	IDA		Mouse	PMID:10859308
Biological Process	GO:0070328	triglyceride homeostasis	Hnf4a	IMP		Mouse	MGI:MGI:1930468|PMID:11158324
Biological Process	GO:0003323	type B pancreatic cell development	hnf4a	IMP	ZFIN:ZDB-MRPHLNO-160621-36	Zfish	PMID:26963759
Biological Process	GO:0006805	xenobiotic metabolic process	HNF4A	IMP		Human	PMID:17827783

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern