Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HOXA2
  • Mouse genes Hoxa2
  • Rat genes
  • Zfish genes hoxa2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hoxa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Hoxa2	IDA		Mouse	MGI:MGI:3525808|PMID:15634706
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hoxa2	IDA		Mouse	MGI:MGI:3525808|PMID:15634706
Molecular Function	GO:0043565	sequence-specific DNA binding	Hoxa2	IDA		Mouse	PMID:15634706
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HOXA2	IDA		Human	PMID:28473536
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HOXA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HOXA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Hoxa2	IDA		Mouse	PMID:10536059
Cellular Component	GO:0005634	nucleus	Hoxa2	IDA		Mouse	PMID:11209945
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:9367425
Biological Process	GO:0035284	brain segmentation	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:9367425
Biological Process	GO:0045165	cell fate commitment	Hoxa2	IMP	MGI:MGI:1857530	Mouse	PMID:7903600
Biological Process	GO:0045165	cell fate commitment	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:7903601
Biological Process	GO:0001709	cell fate determination	Hoxa2	IMP	MGI:MGI:2385711	Mouse	PMID:16221728
Biological Process	GO:0071300	cellular response to retinoic acid	Hoxa2	IDA		Mouse	PMID:23723417
Biological Process	GO:0009953	dorsal/ventral pattern formation	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:10230789
Biological Process	GO:0009953	dorsal/ventral pattern formation	Hoxa2	IGI	MGI:MGI:96183	Mouse	PMID:10230789
Biological Process	GO:0048706	embryonic skeletal system development	Hoxa2	IDA		Mouse	PMID:25889273
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Hoxa2	IGI	MGI:MGI:102778	Mouse	PMID:15634706
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	Hoxa2	IMP	MGI:MGI:2385711	Mouse	PMID:16221728
Biological Process	GO:0042474	middle ear morphogenesis	Hoxa2	IMP	MGI:MGI:2385711	Mouse	PMID:16221728
Biological Process	GO:0042474	middle ear morphogenesis	Hoxa2	IMP	MGI:MGI:1857530	Mouse	PMID:15861402
Biological Process	GO:0042474	middle ear morphogenesis	Hoxa2	IGI	MGI:MGI:102778	Mouse	PMID:15634706
Biological Process	GO:0008045	motor neuron axon guidance	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:9367425
Biological Process	GO:0061061	muscle structure development	Hoxa2	IDA		Mouse	PMID:25889273
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hoxa2	IMP	MGI:MGI:1857530	Mouse	PMID:18164701
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hoxa2	IGI	MGI:MGI:104717	Mouse	PMID:18164701
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hoxa2	IGI	MGI:MGI:96207	Mouse	PMID:18164701
Biological Process	GO:0045665	negative regulation of neuron differentiation	Hoxa2	IGI	MGI:MGI:97495	Mouse	PMID:18164701
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Hoxa2	IDA		Mouse	PMID:21324897
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hoxa2	IDA		Mouse	PMID:15634706
Biological Process	GO:0030182	neuron differentiation	Hoxa2	IMP	MGI:MGI:1857530	Mouse	PMID:18164701
Biological Process	GO:0002076	osteoblast development	Hoxa2	IGI	MGI:MGI:2679336	Mouse	PMID:16751105
Biological Process	GO:0007389	pattern specification process	Hoxa2	IMP	MGI:MGI:1857530	Mouse	PMID:7903600
Biological Process	GO:0007389	pattern specification process	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:7903601
Biological Process	GO:0060037	pharyngeal system development	Hoxa2	IDA		Mouse	PMID:25889273
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hoxa2	IDA		Mouse	PMID:18787068
Biological Process	GO:0021568	rhombomere 2 development	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:7508007
Biological Process	GO:0021569	rhombomere 3 development	Hoxa2	IGI	MGI:MGI:96183	Mouse	PMID:7508007
Biological Process	GO:0021658	rhombomere 3 morphogenesis	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:10230789
Biological Process	GO:0007379	segment specification	Hoxa2	IMP	MGI:MGI:1857626	Mouse	PMID:9367425

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern