Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPGD
  • Mouse genes Hpgd
  • Rat genes Hpgd
  • Zfish genes hpgd,zgc:56585
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hpgd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IDA		Human	PMID:10198228
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IDA		Human	PMID:15581601
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IDA		Human	PMID:16828555
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IDA		Human	PMID:2025296
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IDA		Human	PMID:21072165
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	HPGD	IMP		Human	PMID:8086429
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Hpgd	IDA		Mouse	PMID:15542609
Molecular Function	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Hpgd	IDA		Rat	PMID:9099857|RGD:633016
Molecular Function	GO:0042802	identical protein binding	HPGD	IPI	UniProtKB:P15428	Human	PMID:21072165
Molecular Function	GO:0042802	identical protein binding	Hpgd	IPI	RGD:620087	Rat	PMID:2251293|RGD:11667089
Molecular Function	GO:0051287	NAD binding	HPGD	IDA		Human	PMID:10198228
Molecular Function	GO:0051287	NAD binding	HPGD	IDA		Human	PMID:15581601
Molecular Function	GO:0070403	NAD+ binding	HPGD	IDA		Human	PMID:16828555
Molecular Function	GO:0070403	NAD+ binding	HPGD	IDA		Human	PMID:21072165
Molecular Function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	HPGD	IDA		Human	PMID:16757471
Molecular Function	GO:0004957	prostaglandin E receptor activity	HPGD	IDA		Human	PMID:10198228
Cellular Component	GO:0016323	basolateral plasma membrane	Hpgd	IDA		Mouse	PMID:20448048
Cellular Component	GO:0005737	cytoplasm	Hpgd	IDA		Rat	PMID:24647712|RGD:11667087
Cellular Component	GO:0005829	cytosol	HPGD	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	HPGD	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	Hpgd	IDA		Rat	PMID:24647712|RGD:11667087
Cellular Component	GO:0005654	nucleoplasm	HPGD	IDA		Human	GO_REF:0000052
Biological Process	GO:0097070	ductus arteriosus closure	Hpgd	IMP		Mouse	MGI:MGI:2158520|PMID:11821873
Biological Process	GO:0007565	female pregnancy	HPGD	IDA		Human	PMID:15531523
Biological Process	GO:0007565	female pregnancy	Hpgd	IEP		Rat	PMID:3338612|RGD:11667100
Biological Process	GO:0001822	kidney development	Hpgd	IEP		Rat	PMID:24647712|RGD:11667087
Biological Process	GO:0045786	negative regulation of cell cycle	HPGD	IDA		Human	PMID:15574495
Biological Process	GO:0007567	parturition	HPGD	IDA		Human	PMID:15531523
Biological Process	GO:0043065	positive regulation of apoptotic process	Hpgd	IDA		Rat	PMID:22580984|RGD:11667097
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Hpgd	IMP		Rat	PMID:24657469|RGD:11667099
Biological Process	GO:0006693	prostaglandin metabolic process	HPGD	IDA		Human	PMID:16828555
Biological Process	GO:0006693	prostaglandin metabolic process	HPGD	IDA		Human	PMID:21072165
Biological Process	GO:0006693	prostaglandin metabolic process	Hpgd	IDA		Rat	PMID:18058808|RGD:11667092
Biological Process	GO:1905828	regulation of prostaglandin catabolic process	HPGD	IMP		Human	PMID:8086429
Biological Process	GO:0032355	response to estradiol	Hpgd	IEP		Rat	PMID:3478736|RGD:11667090
Biological Process	GO:0045471	response to ethanol	Hpgd	IDA		Rat	PMID:6574558|RGD:11667091
Biological Process	GO:0032496	response to lipopolysaccharide	Hpgd	IEP		Rat	PMID:12399253|RGD:2316279
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	Hpgd	IEP		Rat	PMID:19383433|RGD:8553438
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	HPGD	IDA		Human	PMID:15574495

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern