Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPS4
  • Mouse genes Hps4
  • Rat genes Hps4
  • Zfish genes hps4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hps4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	HPS4	IDA		Human	PMID:23084991
Molecular Function	GO:0005515	protein binding	HPS4	IPI	UniProtKB:Q92902	Human	PMID:12756248
Molecular Function	GO:0005515	protein binding	HPS4	IPI	UniProtKB:Q92902	Human	PMID:20048159
Molecular Function	GO:0046983	protein dimerization activity	HPS4	IPI	UniProtKB:Q92902	Human	PMID:12663659
Molecular Function	GO:0042803	protein homodimerization activity	HPS4	IPI	UniProtKB:Q9NQG7	Human	PMID:12663659
Molecular Function	GO:0031267	small GTPase binding	HPS4	IPI	UniProtKB:P51151	Human	PMID:20048159
Molecular Function	GO:0031267	small GTPase binding	HPS4	IPI	UniProtKB:Q9NP90	Human	PMID:20048159
Molecular Function	GO:0031267	small GTPase binding	Hps4	IPI	UniProtKB:Q9R0M6	Mouse	MGI:MGI:5795820|PMID:20048159
Molecular Function	GO:0031267	small GTPase binding	Hps4	IPI	UniProtKB:Q9R0M6	Mouse	MGI:MGI:5755324|PMID:26620560
Cellular Component	GO:0031085	BLOC-3 complex	HPS4	IPI		Human	PMID:20048159
Cellular Component	GO:0031085	BLOC-3 complex	HPS4	IPI	UniProtKB:Q92902	Human	PMID:12756248
Cellular Component	GO:0031085	BLOC-3 complex	HPS4	IPI	UniProtKB:Q92902	Human	PMID:20048159
Cellular Component	GO:0031085	BLOC-3 complex	HPS4	IPI	UniProtKB:Q92902	Human	PMID:23084991
Cellular Component	GO:0005737	cytoplasm	HPS4	IDA		Human	PMID:12756248
Cellular Component	GO:0031410	cytoplasmic vesicle	Hps4	IDA		Mouse	PMID:11836498
Cellular Component	GO:0005764	lysosome	HPS4	IDA		Human	PMID:12663659
Cellular Component	GO:0042470	melanosome	HPS4	IDA		Human	PMID:12663659
Cellular Component	GO:0016020	membrane	HPS4	IDA		Human	PMID:12756248
Cellular Component	GO:0042827	platelet dense granule	HPS4	IDA		Human	PMID:12756248
Biological Process	GO:0007596	blood coagulation	Hps4	IMP	MGI:MGI:1856931	Mouse	PMID:6696991
Biological Process	GO:0007040	lysosome organization	HPS4	IDA		Human	PMID:12663659
Biological Process	GO:0030318	melanocyte differentiation	Hps4	IMP	MGI:MGI:1856931	Mouse	PMID:11836498
Biological Process	GO:1903232	melanosome assembly	HPS4	IDA		Human	PMID:23084991
Biological Process	GO:0006996	organelle organization	Hps4	IMP	MGI:MGI:1856931	Mouse	PMID:11836498
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	HPS4	HMP		Human	PMID:24270810
Biological Process	GO:0050821	protein stabilization	HPS4	IPI	UniProtKB:Q92902	Human	PMID:12663659
Biological Process	GO:0006605	protein targeting	HPS4	IDA		Human	PMID:12663659

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern