Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPSE
  • Mouse genes Hpse
  • Rat genes Hpse
  • Zfish genes hpse
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hpse

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030305	heparanase activity	HPSE	IDA		Human	PMID:12213822
Molecular Function	GO:0030305	heparanase activity	Hpse	IDA		Mouse	PMID:27026367
Molecular Function	GO:0030305	heparanase activity	Hpse	IDA		Mouse	PMID:12460766
Molecular Function	GO:0030305	heparanase activity	Hpse	IDA		Rat	PMID:12077130|RGD:632901
Molecular Function	GO:0005515	protein binding	HPSE	IPI	UniProtKB:P18827	Human	PMID:15292202
Molecular Function	GO:0005515	protein binding	HPSE	IPI	UniProtKB:P04196	Human	PMID:20561914
Molecular Function	GO:0005515	protein binding	HPSE	IPI	UniProtKB:P13726	Human	PMID:20634491
Molecular Function	GO:0045545	syndecan binding	HPSE	IDA		Human	PMID:15292202
Cellular Component	GO:0005615	extracellular space	Hpse	IDA		Mouse	PMID:27026367
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HPSE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	HPSE	IDA		Human	PMID:15126626
Cellular Component	GO:0045121	membrane raft	Hpse	IDA		Mouse	MGI:MGI:3721153|PMID:17689495
Cellular Component	GO:0005654	nucleoplasm	HPSE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	HPSE	IDA		Human	PMID:20309870
Cellular Component	GO:0005634	nucleus	Hpse	IDA		Mouse	MGI:MGI:3721153|PMID:17689495
Cellular Component	GO:0005634	nucleus	Hpse	IDA		Mouse	MGI:MGI:3574236|PMID:15793281
Biological Process	GO:0060055	angiogenesis involved in wound healing	Hpse	IDA		Mouse	MGI:MGI:3574236|PMID:15793281
Biological Process	GO:0007160	cell-matrix adhesion	HPSE	IDA		Human	PMID:12773484
Biological Process	GO:0061028	establishment of endothelial barrier	Hpse	IDA		Mouse	PMID:27026367
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	HPSE	IDA		Human	PMID:12213822
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	Hpse	IDA		Mouse	PMID:12460766
Biological Process	GO:0030202	heparin metabolic process	Hpse	IDA		Mouse	PMID:27026367
Biological Process	GO:0030202	heparin metabolic process	Hpse	IMP		Mouse	PMID:27026367
Biological Process	GO:0030194	positive regulation of blood coagulation	HPSE	IDA		Human	PMID:20634491
Biological Process	GO:0051798	positive regulation of hair follicle development	Hpse	IDA		Mouse	MGI:MGI:3574236|PMID:15793281
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	HPSE	IDA		Human	PMID:20309870
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Hpse	IDA		Mouse	MGI:MGI:5284762|PMID:18589009
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	HPSE	IDA		Human	PMID:15044433
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Hpse	IDA		Mouse	MGI:MGI:3721153|PMID:17689495
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	HPSE	IDA		Human	PMID:16452201
Biological Process	GO:0071806	protein transmembrane transport	Hpse	IMP		Mouse	PMID:27026367
Biological Process	GO:0051797	regulation of hair follicle development	HPSE	IDA		Human	PMID:18557927
Biological Process	GO:0010033	response to organic substance	Hpse	IDA		Mouse	PMID:31402170
Biological Process	GO:0061042	vascular wound healing	Hpse	IDA		Mouse	MGI:MGI:3574236|PMID:15793281
Biological Process	GO:0042060	wound healing	Hpse	IDA		Mouse	MGI:MGI:3574236|PMID:15793281

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern