Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPX
  • Mouse genes Hpx
  • Rat genes Hpx
  • Zfish genes hpxa,hpxb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hpx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	HPX	IPI	UniProtKB:Q9Y5Y0	Human	PMID:20610401
Cellular Component	GO:0072562	blood microparticle	HPX	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HPX	HDA		Human	PMID:28675934
Cellular Component	GO:0070062	extracellular exosome	HPX	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HPX	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	HPX	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	HPX	IDA		Human	PMID:19433579
Biological Process	GO:0071391	cellular response to estrogen stimulus	hpxa	IDA		Zfish	PMID:18618001
Biological Process	GO:0042168	heme metabolic process	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18556779
Biological Process	GO:0020027	hemoglobin metabolic process	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:10572107
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0060332	positive regulation of response to type II interferon	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0051246	regulation of protein metabolic process	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:10572107
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Hpx	IMP	MGI:MGI:2447193	Mouse	PMID:18641331

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern