Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HRC
  • Mouse genes Hrc
  • Rat genes Hrc
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hrc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	HRC	IPI	UniProtKB:P16615	Human	PMID:17526652
Molecular Function	GO:0005509	calcium ion binding	HRC	IDA		Human	PMID:24125847
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:Q13061	Human	PMID:17526652
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:P14923	Human	PMID:17924338
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:E9Q9K5	Human	PMID:24125847
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:Q28820	Human	PMID:24125847
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:E9Q401	Human	PMID:24805197
Molecular Function	GO:0005515	protein binding	HRC	IPI	UniProtKB:Q32M78	Human	PMID:32296183
Molecular Function	GO:0044325	transmembrane transporter binding	HRC	IPI	UniProtKB:P16615	Human	PMID:17526652
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Hrc	IDA		Mouse	PMID:16600288
Cellular Component	GO:0030018	Z disc	HRC	IDA		Human	PMID:24125847
Biological Process	GO:0055074	calcium ion homeostasis	Hrc	IDA		Mouse	PMID:16600288
Biological Process	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	Hrc	IMP		Rat	PMID:22952658|RGD:9685495
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Hrc	IMP		Rat	PMID:22952658|RGD:9685495
Biological Process	GO:0045823	positive regulation of heart contraction	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:0010460	positive regulation of heart rate	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:1901899	positive regulation of relaxation of cardiac muscle	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:0008016	regulation of heart contraction	Hrc	IDA		Mouse	PMID:16600288
Biological Process	GO:0002027	regulation of heart rate	HRC	IMP		Human	PMID:18617481
Biological Process	GO:0033135	regulation of peptidyl-serine phosphorylation	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	HRC	IGI	UniProtKB:B9EIW1	Human	PMID:24125847

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern