Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HRG
  • Mouse genes Hrg
  • Rat genes Hrg,LOC681544
  • Zfish genes fetub
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hrg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0020037	heme binding	HRG	IDA		Human	PMID:678554
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	HRG	IDA		Human	PMID:15138272
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	HRG	IDA		Human	PMID:16436387
Molecular Function	GO:0008201	heparin binding	HRG	IDA		Human	PMID:16436387
Molecular Function	GO:0008201	heparin binding	HRG	IDA		Human	PMID:21304106
Molecular Function	GO:0019865	immunoglobulin binding	HRG	IDA		Human	PMID:10514432
Molecular Function	GO:0046872	metal ion binding	HRG	IDA		Human	PMID:678554
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:P07996	Human	PMID:11134179
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:P00747	Human	PMID:15220341
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:P25705	Human	PMID:19285951
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:P00747	Human	PMID:19712047
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:Q9Y251	Human	PMID:20561914
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:P00748	Human	PMID:21304106
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:Q96PM5	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:Q99XU0	Human	PMID:24825900
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HRG	IPI	UniProtKB:O76081-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Hrg	IPI	UniProtKB:Q03350	Mouse	MGI:MGI:3530701|PMID:15748999
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Hrg	IMP	MGI:MGI:3789962	Mouse	PMID:15869579
Molecular Function	GO:0005102	signaling receptor binding	HRG	IDA		Human	PMID:16436387
Molecular Function	GO:0008270	zinc ion binding	HRG	IDA		Human	PMID:15138272
Molecular Function	GO:0008270	zinc ion binding	HRG	IDA		Human	PMID:16436387
Molecular Function	GO:0008270	zinc ion binding	HRG	IDA		Human	PMID:21304106
Cellular Component	GO:0072562	blood microparticle	HRG	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	HRG	IDA		Human	PMID:15220341
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HRG	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HRG	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HRG	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Hrg	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0036019	endolysosome	Hrg	IDA		Mouse	PMID:23395172
Cellular Component	GO:0070062	extracellular exosome	HRG	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HRG	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	HRG	IDA		Human	PMID:18797515
Cellular Component	GO:0005576	extracellular region	HRG	HDA		Human	PMID:27068509
Cellular Component	GO:0061474	phagolysosome membrane	Hrg	IDA		Mouse	PMID:23395172
Cellular Component	GO:0031982	vesicle	Hrg	IDA		Mouse	PMID:23395172
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	HRG	IDA		Human	PMID:18797515
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	Hrg	IMP		Mouse	MGI:MGI:5294287|PMID:18797515
Biological Process	GO:0051838	cytolysis by host of symbiont cells	HRG	IDA		Human	PMID:18797515
Biological Process	GO:0050832	defense response to fungus	HRG	IDA		Human	PMID:18797515
Biological Process	GO:0050832	defense response to fungus	Hrg	IMP		Mouse	MGI:MGI:5294287|PMID:18797515
Biological Process	GO:0042730	fibrinolysis	Hrg	IMP	MGI:MGI:3789962	Mouse	PMID:15869579
Biological Process	GO:0097037	heme export	Hrg	IMP		Mouse	PMID:23395172
Biological Process	GO:0015886	heme transport	Hrg	IMP		Mouse	PMID:23395172
Biological Process	GO:0016525	negative regulation of angiogenesis	HRG	IDA		Human	PMID:14744774
Biological Process	GO:0016525	negative regulation of angiogenesis	HRG	IDA		Human	PMID:16436387
Biological Process	GO:0016525	negative regulation of angiogenesis	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0016525	negative regulation of angiogenesis	HRG	IDA		Human	PMID:19903770
Biological Process	GO:0016525	negative regulation of angiogenesis	Hrg	IMP		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	Hrg	IMP		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0007162	negative regulation of cell adhesion	HRG	IDA		Human	PMID:14744774
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0030308	negative regulation of cell growth	HRG	IDA		Human	PMID:21215706
Biological Process	GO:0030308	negative regulation of cell growth	Hrg	IDA		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0008285	negative regulation of cell population proliferation	HRG	IDA		Human	PMID:14744774
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	HRG	IDA		Human	PMID:14744774
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	HRG	IDA		Human	PMID:16436387
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0051918	negative regulation of fibrinolysis	Hrg	IMP	MGI:MGI:3789962	Mouse	PMID:15869579
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	HRG	IDA		Human	PMID:16489009
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0030168	platelet activation	HRG	IDA		Human	PMID:19903770
Biological Process	GO:0043065	positive regulation of apoptotic process	HRG	IDA		Human	PMID:14744774
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	HRG	IDA		Human	PMID:21215706
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	Hrg	IMP		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	HRG	IDA		Human	PMID:14744774
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	HRG	IDA		Human	PMID:16436387
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	HRG	IDA		Human	PMID:21215706
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	Hrg	IMP		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0030193	regulation of blood coagulation	HRG	IDA		Human	PMID:21304106
Biological Process	GO:0030193	regulation of blood coagulation	HRG	IDA		Human	PMID:6740558
Biological Process	GO:0030193	regulation of blood coagulation	Hrg	IMP		Mouse	MGI:MGI:3789419|PMID:15869579
Biological Process	GO:0010468	regulation of gene expression	HRG	IDA		Human	PMID:21215706
Biological Process	GO:0010468	regulation of gene expression	Hrg	IMP		Mouse	MGI:MGI:5427055|PMID:22348394
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0010543	regulation of platelet activation	Hrg	IMP		Mouse	MGI:MGI:3789419|PMID:15869579
Biological Process	GO:0010543	regulation of platelet activation	Hrg	IMP		Mouse	MGI:MGI:4941083|PMID:21264222
Biological Process	GO:0043254	regulation of protein-containing complex assembly	HRG	IDA		Human	PMID:16489009
Biological Process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	Hrg	IDA		Mouse	PMID:23395172
Biological Process	GO:0014070	response to organic cyclic compound	Hrg	IDA		Mouse	PMID:23395172

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern